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Source: GEO: Gene Expression Omnibus
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Total 772 results found since Jan 2013.
GSE119072 Microarray upon Sp110 knockdown in HepG2.2.15 cells
Contributors : Isha Sengupta ; Dipanwita Das ; Shivaram P Singh ; Runu Chakravarty ; Chandrima DasSeries Type : Expression profiling by arrayOrganism : Homo sapiensHepatitis B virus (HBV), belonging to Hepadnaviridae family, remains undetected in early infection and is known to be the cause of several hepatic diseases leading to cirrhosis and hepatocellular carcinoma. We have found that PML-Nuclear Body Speckled 110kDa (Sp110), is hyper-expressed upon HBV infection and intriguingly, Sp110 knock-down significantly reduced viral DNA-load in the culture supernatant of HepG2.2.15 (a HBV expressing cell-line). To understand the...
Source: GEO: Gene Expression Omnibus - August 24, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE126894 A TFAP2C Gene Signature is Predictive of Outcome in HER2 Breast Cancer (RNA-Seq)
Conclusions: Knockdown of TFAP2C with co-knockdown of CDH5 in SKBR-3 confirmed no significant effect on invasion, though there was a slight reduction in invasiveness with knockdown of CDH5 that failed to reach statistical significance (p=0.12). These findings support the conclusion that regulation of CDH5 and CDKN1A contribute to alterations of proliferation and invasiveness induced by knockdown of TFAP2C.
Source: GEO: Gene Expression Omnibus - April 13, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE201426 RNA sequencing of HeLa cells
In this study TOP3A, TOP1MT or both TOP3A and TOP1MT have been knocked down using siRNAs to determine the effect of the topoisomerases on mitochondrial transcription. RNA was isolated from ctrl siRNA, TOP3A siRNA, TOP1MT siRNA and TOP3A + TOP1MT siRNA transfected cells after 6 days of transfection.
Source: GEO: Gene Expression Omnibus - October 11, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE180610 Differential gene expression in MEF SEC24D knockout cells with additional SEC24s knockdown
Contributors : Jinoh Kim ; Chung-Ling LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe transfected MEF SEC24D KO cells with SEC24B siRNA for a double KD or combined SEC24s siRNA (SEC24a, 24B and 24C) for a quadruple KD. Cells were transfected with siRNA or Scramble siRNA (control) for 2 days then total RNA for each knockdown sample was extracted and purified for RNA-seq to evaluate the change in transcriptome.
Source: GEO: Gene Expression Omnibus - September 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE65665 Gene expression profiling of effect of Yap inhibition in a genetically engineered mouse model of hepatocellular carcinoma
Contributors : Julien Fitamant ; Nabeel Bardeesy ; Kenneth N RossSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDefective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. We show that YAP functions as a rheostat maintaining metabolic specialization, differentiation and quiescence within the hepatocyte compartment. Importantly, treatment with siRNA-lipid nanoparticles (siRNA-LNPs) targeting YAP restores hepatocyte differentiation an...
Source: GEO: Gene Expression Omnibus - March 7, 2015 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE73243 Expression data from U87 xenograft tissues
Contributor : Varda Shoshan-BarmatzSeries Type : Expression profiling by arrayOrganism : Homo sapiensU87 xenograft tumors treated with scrambled siRNA (Tas_73, Tas_78) or siRNA against VDAC1 (Tas_57, Tas_61)We used microarrays to detail the global effect of siRNA against VDAC1 on subcotenous xenograft U87 cells tumors
Source: GEO: Gene Expression Omnibus - February 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE74626 Differential gene expression in neuroblastoma cells after transfection with control siRNA, MYCN siRNA or TFAP4 siRNA.
Contributors : Chengyuan Xue ; Tao LiuSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe analyed the gene expression profiles after knocking down MYCN or TFAP4. Results showed that transcription factor MYCN and TFAP4 commonly regulats a subset of genes that may contribute to neuroblastoma cells proliferation and migration.
Source: GEO: Gene Expression Omnibus - November 2, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE90582 Gene expression profiling of LRRC26-depleted HCC70 cells
Contributors : Yoshimasa Miyagawa ; Yosuke Matsushita ; Toyomasa KatagiriSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo serach gene expression change under knockdown of LRRC26, Leucin Rich Repeat Containing 26 in human triple negative breast cancer cells HCC70, we performed genome-wide DNA microarray analysis and compared the expression levels of control-siRNA treated cells and LRRC26-siRNA treates cells at 48 to 72 h after siRNA transfection
Source: GEO: Gene Expression Omnibus - November 30, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE90139 Differential gene expression analysis of MYCN-amplified neuroblastoma cells after transfection with Control siRNA, LYAR siRNA-6 or LYAR siRNA-10
Contributors : Tao Liu ; Bernard Atmadibrata ; Bing Lee ; Nicholas HoSeries Type : Expression profiling by arrayOrganism : Homo sapiensN-Myc oncoprotein induces neuroblastoma and exerts its biological effects through modulation of its target genes.We identified that MYCN modulates LYAR expression and we are interested to determine which signaling pathway LYAR regulates.
Source: GEO: Gene Expression Omnibus - December 31, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
GSE104015 Total and AGO1 immunoprecipitated small RNA from Arabidopsis thaliana wild-type and ago1-57 mutant
Contributors : Beno ît Derrien ; Marion Clavel ; Nicolas Baumberger ; Taichiro Iki ; Alexis Sarazin ; Thibaut Hacquard ; María R Ponce ; Olivier Voinnet ; Véronique Ziegler-Graff ; Hervé Vaucheret ; Olivier Voinnet ; José L Micol ; Pascal GenschikSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Arabidopsis thalianaIn Arabidopsis thaliana, ARGONAUTE1 (AGO1) plays a central role[AQ1] in microRNA (miRNA) and small interfering RNA (siRNA)- mediated silencing and is a key component in antiviral responses. The polerovirus F-box P0 protein triggers AGO1 degradation as a viral counterdefense. Her...
Source: GEO: Gene Expression Omnibus - June 22, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research
GSE102112 RNAseq analyze global transcriptome of changes between siIRF3 and siYAP in Gastric cancer cells
Contributors : Shi Jiao ; Jingmin GuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: To investigate the signal crosstalk between IRF3 and YAP, RNA-sequencing (RNA-seq) was performed to analyze the genome-wide changes by the knockdown of IRF3 or YAP in HGC-27 cells.Methods: Total RNA was extracted from HGC-27 cell after transfection with negative control siRNA (n.c.), IRF3 siRNA (siIRF3) or YAP siRNA (siYAP). Then total RNA was quality controlled and quantified using an Agilent 2100 Bioanalyzer. After converting to cDNA and building library, high-throughput sequencing was per...
Source: GEO: Gene Expression Omnibus - August 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE109067 Identification of G-protein-coupled receptors associated with differentiation and development of porcine subcutaneous preadipocytes.
Contributors : Hirohide Uenishi ; Ikuyo Nakajima ; Yuki Nakamura ; Aisaku Arakawa ; Satoshi MikawaSeries Type : Expression profiling by arrayOrganism : Sus scrofaG-protein-coupled receptors (GPCRs) are membrane proteins that enable cells to sense molecular signals and to respond in a broad range of biological processes according to the circumstances of cells. Recent studies elucidated that short-medium chain fatty acids can stimulate GPCRs to activate signaling pathways for adipocyte differentiation. As for differentiation of Porcine Subcutaneous Pre-Adipocyte (PSPA), it has been demonstrated that octanoate supplementation...
Source: GEO: Gene Expression Omnibus - May 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Sus scrofa Source Type: research
GSE139867 Transcriptome changes in bovine oocytes caused by microinjection
In this study, we investigated the effect of microinjection on oocytes transcriptome changes through scrambled siRNA injection.Method: Scrambled siRNA injection followed by RNA-seq of single oocytes.Result:Our result showed 119 transcripts were differentially expressed of which 76 were down-regulated after scrambled siRNA injection.
Source: GEO: Gene Expression Omnibus - December 20, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Bos taurus Source Type: research
GSE146064 Region-specific DNA-binding properties of NFIA in the adult mouse brain
Contributors : Anna Y Huang ; Debosmita Sardar ; Brittney Lozzi ; Benjamin DeneenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to profile NFIA DNA-binding properties in the adult mouse brain. We performed chromatin immunoprecipitation of NFIA in the hippocampus and olfactory bulb of wildtype mice, and samples were subjected to sequencing. We find that NFIA preferentially binds DNA in the hippocampus but not in the olfactory bulb as evidenced by the distinct lack of NFIA binding peaks in the olfactory bulb. Mass spectrometry results suggested t...
Source: GEO: Gene Expression Omnibus - February 28, 2020 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE98335 SZ 95 sebocytes - OLR1 knockdown - treated with UV-oxidized PAPC
Contributors : Ionela Nagelreiter ; Masomeh Parvadeh ; Marie Narzt ; Lucian Beer ; Christopher Kremslehner ; Ximena Muresan ; Johannes Grillari ; Christos Zouboulis ; Erwin Tschachler ; Florian GruberSeries Type : Expression profiling by arrayOrganism : Homo sapiensHuman SZ95 sebocytes were transfected by lipofection with either scramble siRNA or OLR1 siRNA and after 24h were treated with 25 µg/ml of UV-oxidized 1-palmitoyl-2-arachidonoyl-sn-phosphocholine (UVPAPC) for 7 hours. Phospholipid oxidation products (OxPL) are versatile stress signaling mediators in the skin. These lipid signaling molecules can be generated non-...
Source: GEO: Gene Expression Omnibus - April 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
