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Source: GEO: Gene Expression Omnibus

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Total 772 results found since Jan 2013.

GSE116188 Transcriptional profiling of WM1976 cells with siRNA knockdown of the long non-coding RNA SLNCR
Contributors : Karyn Schmidt ; Carl NovinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-Seq was used to profile transcriptional changes induced by siRNA knockdown of the long non-coding RNA SLNCR (all isoforms).
Source: GEO: Gene Expression Omnibus - September 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE115268 human pulmonary artery (endothelial and smoorh muscle) cells : control vs ARSB-siRNA transfected
Contributors : Anna Lalik ; Adam Golda ; Sebastian StudentSeries Type : Expression profiling by arrayOrganism : Homo sapiensTranscriptional profiling of human pulmonary artery endothelial (HAPEC) and smooth muscle (PASM) cells comparing control untreated cells with cells transfected with ARSB-siRNA. Goal was to determine the effects of silenced of arylsufatase B on global gene expression in HAPEC and PASM cells.
Source: GEO: Gene Expression Omnibus - October 1, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE107692 siRNA-mediated silencing of ORAI3 in MDA-MB-468 breast cancer cells exposed to hypoxia
Contributors : Iman Azimi ; Gregory Baillie ; Sarah Roberts-Thomson ; Gregory MonteithSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the effect of siRNA-mediated silencing of ORAI3 in MDA-MB-468 basal-like breast cancer cells exposed to 48 and 72 h hypoxia
Source: GEO: Gene Expression Omnibus - December 19, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE102057 Synthetic lethal siRNA screen for TN-IBC cell line SUM149PT using kinome library with EPA treatment
Contributors : Angie M Torres-Adorno ; Yuan Qi ; Naoto T UenoSeries Type : OtherOrganism : Homo sapiensSynthetic lethal siRNA screen using a kinome library containing 939 druggable genes in the TN-IBC cell line SUM149PT, in combination with EPA treatment.
Source: GEO: Gene Expression Omnibus - January 31, 2019 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

GSE128846 Knock-down of all HIF3A splice variants under 1 % hypoxia by siRNA targeting a shared region in Hep3B cells
Contributors : Jussi-Pekka Tolonen ; Johanna MyllyharjuSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe human HIF3A gene undergoes extensive alternative splicing resulting in seven known isoforms. The short splice variant, HIF-3alpha4, is an inhibitor of the hypoxia response driven by HIF-1 and HIF-2. The role of the long isoforms remains unclear.We used cDNA microarray to study the overall impact of HIF3A knock-down by transfecting Hep3B cells with siRNA targeting a region shared by all splice variants under 1 % hypoxia.
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE137035 transcriptional changes after YAP/TAZ siRNA mediated knockdown and BMP-2 stimulation
Contributors : Maria Reichenbach ; Paul Rikeit ; Stefan Boerno ; Petra KnausSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOsteogenesis is influenced by a variety of factors including growth factors - especially those of the TGF-  superfamily - and Hippo signaling. Consequently, we hypothesize that the YAP/TAZ pathway is intertwining with TGF-beta and BMP signaling resulting in osteogenic differentiation. Therefore, we performed a comprehensive RNA Seq study including both YAP/TAZ depletion by siRNA and BMP stimulation co nditions in human fetal osteoblats cell line hFOB 1.10.
Source: GEO: Gene Expression Omnibus - August 31, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE143258 Poly(A) RNA sequencing of Silencing Defective 2 (SDE2) depletion in HeLa cells via siRNA
In this study, we use Poly(A) purified RNA sequencing to identify the alternative splicing profile in Hela cells following depletion of SDE2 via siRNA. Our data demonstrate that SDE2 depletion causes widespread changes in alternative splicing (AS), with increased intron retention being the most common event. These retained introns are significantly shorter, have a higher GC content, and overall maintain weaker 5' and 3' splice sites than other introns throughout the genome. Following the depletion of SDE2, increased intron retention causes catastrophic consequences for the cell, including defects in mitotic progression, gl...
Source: GEO: Gene Expression Omnibus - January 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE112429 HMGB1 and Alu-siRNA inhibit the growth of human lung tumor cells
Contributors : Warayupa Thompat ; Apiwat MutiranguraSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe performed expression profiling using microarray technology. The expression profiling identified genes or mechanism potentially regulating the proliferation of human lung cancer cells by BoxA of HMGB1 and Alu-siRNA transfection. The RNAs of our experiment were hybridized with Agilent SurePrint G3 Human GE 8X60K, V3 Microarrays (Agilent ®).
Source: GEO: Gene Expression Omnibus - March 26, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE173302 RNA sequencing of control and CIP2A siRNA silenced basal-like breast cancer cell line HCC38
Contributors : Jukka Westermarck ; Srikar Nagelli ; Anni LaineSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe purpose is to study the transcriptional changes in basal like breast cancer cell line HCC38 on depletion of CIP2A. We have used 3 unique siRNA sequences of CIP2A and 3 control samples (Mock and 2 unique non-targeting sequences) for the RNA Seq. We identified differentially expressed genes in CIP2A knockdown conditions compared to the control samples and identified pathways regulated by CIP2A in this cell line using GSEA.
Source: GEO: Gene Expression Omnibus - April 27, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE173426 Nuclear and cytoplasmic RNA exosomes and PELOTA limit miRNA-induced secondary siRNA production
In this study, we aim at understanding which RNA degradation pathways are involved in keeping the secondary siRNA production in check in Arabidopsis thaliana. We have sequenced small RNAs from various T-DNA insertation single mutants and compared their capability of producing ectopic secondary siRNAs from endogenous miRNA targets. The mutants used in the work stem from three library pools from three different experiments. Libraries from all three experiments are submitted together here. The experiments can be distinguished by their title and their tag:experiment. There is a matrix of normalized reads from each pool of libr...
Source: GEO: Gene Expression Omnibus - April 28, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Arabidopsis thaliana Source Type: research

GSE174612 Gene expression data from human breast cancer MCF-7 cells and its 4-hydroxytamoxifen-resistant derivative OHTR cells treated with an siRNA targeting TRIM47
Series Type : Expression profiling by arrayOrganism : Homo sapiensTo evaluate the effect of TRIM47 on NF- κB signaling in breast cancer cells, expression of TRIM47 was knocked down in MCF-7 cells and its 4-hydroxytamoxifen (OHT)-resistant derivative OHTR cells by small interfering RNA (siRNA). Microarray analysis was performed to analyze gene expression profiles of these cells.
Source: GEO: Gene Expression Omnibus - June 11, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE173161 Comparative analysis of gene expression after Oct4 or Scrambled siRNA knockdown in HNSCC cell lines
Contributors : Anna Dubrovska ; Linda Hein ; Vasyl LukiyanchukSeries Type : Expression profiling by arrayOrganism : Homo sapiensBy employing a global gene expression profiling, we performed analysis of the molecular pathways which are deregulated in head-and-neck cancer cell lines FaDu, Cal33 and UTSCC5 after siRNA mediated knockdown of Oct4 comparing to Scrambled.
Source: GEO: Gene Expression Omnibus - July 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE172094 siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells
Contributors : Salma Ben-Salem ; Eduardo Cortes ; Qiang Hu ; Song Liu ; Hannelore HeemersSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo study the effect of siRNA-mediated E2F1 and E2F2 silencing in growth-stimulated prostate cancer cells.
Source: GEO: Gene Expression Omnibus - October 14, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE179241 Gene expression data from human breast cancer MCF-7 cells treated with siRNA targeting OCT1
Series Type : Expression profiling by arrayOrganism : Homo sapiensTo evaluate the effect of OCT1 in breast cancer cells, expression of OCT1 was knocked down in MCF-7 cells by small interfering RNA (siRNA). Microarray analysis was performed to analyze gene expression profiles of these cells.
Source: GEO: Gene Expression Omnibus - October 25, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE183147 Genome-wide maps of double strand breaks after siRNA knockdown of DDX41 in HCT116 cells
We report the first genome-wide mapping of fragility hotspots after siRNA-mediated knockdown of the DEAD-box helicase DDX41 in HCT116 cells using sBLISS. DDX41 defficient cells display elevated levels of genomic instability. sBLISS analysis revealed that hotspots for genomic instability in the absence of DDX41 are located around the transcription start site of transcribed genes.
Source: GEO: Gene Expression Omnibus - November 17, 2021 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research