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STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial HypertensionNovelty and Significance Pulmonary Hypertension
An increase in cytosolic free Ca2+ concentration ([Ca2+]cyt) in pulmonary artery smooth muscle cells (PASMCs) triggers pulmonary vasoconstriction and stimulates PASMC proliferation leading to vascular wall thickening. Here, we report that STIM2 (stromal interaction molecule 2), a Ca2+ sensor in the sarcoplasmic reticulum membrane, is required for raising the resting [Ca2+]cyt in PASMCs from patients with pulmonary arterial hypertension (PAH) and activating signaling cascades that stimulate PASMC proliferation and inhibit PASMC apoptosis. Downregulation of STIM2 in PAH-PASMCs reduces the resting [Ca2+]cyt, whereas overexpre...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Shanshan Song, Shane G. Carr, Kimberly M. McDermott, Marisela Rodriguez, Aleksandra Babicheva, Angela Balistrieri, Ramon J. Ayon, Jian Wang, Ayako Makino, Jason X.-J. Yuan Tags: Pulmonary Hypertension, Vascular Disease Original Articles Source Type: research

Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle ArteriesNovelty and Significance G Protein Signaling and Vasoconstriction
Studies suggest that arteriolar pressure–induced vasoconstriction can be initiated by GPCRs (G protein–coupled receptors), including the AT1R (angiotensin II type 1 receptor). This raises the question, are such mechanisms regulated by negative feedback? The present studies examined whether RGS (regulators of G protein signaling) proteins in vascular smooth muscle cells are colocalized with the AT1R when activated by mechanical stress or angiotensin II and whether this modulates AT1R-mediated vasoconstriction. To determine whether activation of the AT1R recruits RGS5, an in situ proximity ligation assay was performed in...
Source: Hypertension - November 8, 2017 Category: Cardiology Authors: Kwangseok Hong, Min Li, Zahra Nourian, Gerald A. Meininger, Michael A. Hill Tags: Basic Science Research, Cell Signaling/Signal Transduction, Vascular Biology, Hypertension Original Articles Source Type: research

Abstract 122: Activation of Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) Enhances Cyclooxygenase 2 Expression via Promoter Antioxidant Response Element in Preglomerular Vascular Smooth Muscle Cells (PGVSMCs) Session Title: Concurrent XVIII C: Oxidative Stress II
In conclusion, these results show a novel role of Nrf2 in inducing COX2 expression through binding to promoter ARE in the absence of increased ROS in rat PGVSMCs.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Luo, Z., Welch, W. J., Wilcox, C. S. Tags: Session Title: Concurrent XVIII C: Oxidative Stress II Source Type: research

Abstract P086: Superoxide but Not Hydrogen Peroxide Increases Nuclear Translocation of Transcription Factor Sp3 and AT1 Receptor Expression in the Renal Cells Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Age-associated oxidative stress causes up-regulation of renal AT1 receptor function (AT1R) and hypertension in aging Fischer Brown Norway (FBN) rats. Here we studied the mechanism of up-regulation of renal AT1R, and further tested superoxide Vs hydrogen peroxide (H2O2) specificity in this phenomenon. We found that transcription factor Sp3 plasmid increased (Control vs Sp3: 0.1165 ± 0.01 vs 0.3810 ± 0.03) while Sp3 siRNA decreased (Control siRNA vs Sp3 siRNA: 1.11 ± 0.25 vs 0.64 ± 0.06) the levels of AT1 receptor protein in human kidney (HK2) cells. Whereas transcription factor NF-kB p-65 plasmid...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Saleem, M. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Abstract 511: Endothelial Cell-specific Liver Kinase B1 Deletion Causes Hypertension in Mice in vivo Poster Session II
Conclusions- Our findings indicate that endothelial cell LKB1 plays an essential role in regulating eNOS activity, endothelial function, and blood pressure through modulating AMPK-mediated caveolin-1expression.
Source: Hypertension - October 30, 2013 Category: Cardiology Authors: Zhang, W., Zou, M. Tags: Poster Session II Source Type: research