Filtered By:
Source: Stem Cells
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 47 results found since Jan 2013.
Focal adhesion kinase and wnt signalling regulates human ductal carcinoma in situ stem cell activity and response to radiotherapy
Abstract
Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. 20% of patients treated with surgery and radiotherapy for ductal carcinoma in Situ (DCIS) of the breast recur and our previous data shows that high grade DCIS have increased numbers of CSCs. Here, we investigate the role of Focal Adhesion Kinase (FAK) and Wnt pathways in DCIS stem cells and their capacity to survive irradiation.
Using DCIS cell lines and patient samples we demonstrate that CSC‐enriched populations are relatively radioresistant and possess high FA...
Source: Stem Cells - September 3, 2014 Category: Stem Cells Authors: Kathryn E Williams, Nigel J Bundred, Göran Landberg, Robert B Clarke, Gillian Farnie Tags: Original Research Source Type: research
The Kynurenine Pathway of Tryptophan Degradation is Activated During Osteoblastogenesis
ABSTRACT
The mechanisms involved in the anabolic effect of IFNγ on bone have not been carefully examined. Using microarray expression analysis, we found that IFNγ upregulates a set of genes associated with a tryptophan degradation pathway, known as the kynurenine pathway, in osteogenic differentiating human mesenchymal stem cells. We therefore hypothesized that activation of the kynurenine pathway plays a role in osteoblastogenesis even in the absence of IFNγ. Initially, we observed a strong increase in tryptophan degradation during osteoblastogenesis with and without IFNγ in the media. We next blocked indoleamine 2,3...
Source: Stem Cells - September 3, 2014 Category: Stem Cells Authors: Christopher Vidal, Wei Li, Brigitte Santner‐Nanan, Chai K. Lim, Gilles J. Guillemin, Helen J. Ball, Nicholas H. Hunt, Ralph Nanan, Gustavo Duque Tags: Translational and clinical research Source Type: research
