Filtered By:
Source: Stem Cells

This page shows you your search results in order of date.

Order by Relevance | Date

Total 47 results found since Jan 2013.

Increased Lipogenesis Is Critical for Self ‐Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega‐3 Fatty Acids
Breast cancer stem cells (CSC) have a distinct fatty acid profile due to the aberrant expressions of lipogenic enzymes (eg, FAS, SCD1, and FADS1/2), which are highly involved in sustaining their self-renewal, and proliferative capabilities. Omega-3 PUFA can effectively suppress the self-renewal and growth of breast CSC by downregulation of the lipogenic enzymes, especially SCD1. AbstractAberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addr...
Source: Stem Cells - September 6, 2021 Category: Stem Cells Authors: Haiqing Luo, Chih ‐Yu Chen, Xiangyong Li, Xin Zhang, Chien‐Wen Su, Yinhua Liu, Tinglan Cao, Lei Hao, Meng Wang, Jing Xuan Kang Tags: Cancer Stem Cells Source Type: research

High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Canonical Notch signaling is required for bone morphogenetic protein ‐mediated human osteoblast differentiation
Bone morphogenetic protein (BMP) stimulation of bone ‐marrow‐derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMP‐induced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induc ed osteoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow‐derived human mesenchymal stem cells (hMSC) can be induced by stimulation with canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMPs). However, it remains elusive how t...
Source: Stem Cells - June 23, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research

Canonical Notch Signaling is Required for Bone Morphogenetic Protein ‐mediated Human Osteoblast Differentiation
BMP stimulation of bone ‐marrow derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMPinduced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induced os teoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow derived human mesenchymal stem cells (hMSC) can be induced by stimulation with either canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP). However, it remains elusive how these two pathways lead to the ...
Source: Stem Cells - June 13, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research

TGF ‐β secreted by human umbilical cord blood‐derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF‐α and IgE
This study investigated the role of transforming growth factor‐beta (TGF‐β) in the therapeutic effect of hUCB‐MSCs on AD. Small interfering RNA (siRNA)‐ mediated depletion of TGF‐β disrupted the therapeutic effect of hUCB‐MSCs in a mouse model of AD by attenuating the beneficial changes in histopathology, mast cell infiltration, tumor necrosis factor‐alpha (TNF‐α) expression, and the serum IgE level. To confirm that hUCB‐MSCs regulate se cretion of TNF‐α, we investigated whether they inhibit TNF‐α secretion by activated LAD2 cells. Coculture with hUCB‐MSCs significantly inhibited secretion of T...
Source: Stem Cells - April 13, 2020 Category: Stem Cells Authors: Hwan hee Park, Seunghee Lee, Yeonsil Yu, Sae Mi Yoo, Song Yi Baek, Namhee Jung, Kwang ‐Won Seo, Kyung‐Sun Kang Tags: Translational and Clinical Research Source Type: research

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/ β‐catenin signaling
This study has demonstrated that ras homolog family member A (RhoA), along with its major effector, Rho ‐associated kinases 1 (ROCK1) activates β‐catenin signaling to promote osteogenic differentiation and restrain adipogenic differentiation. Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/β‐catenin signaling pathway, and thereby reciprocally regulates osteogenic and adipogenic differentiation of mesenchymal progenitor cellsin vitro andin vivo. The study suggests the potential of LPAR4 as a pharmaceutical target to treat metabolic disorders such as osteoporosis.
Source: Stem Cells - November 27, 2019 Category: Stem Cells Authors: Yan Xie, Xiaochen Wang, Xiaowen Wu, Lijie Tian, Jie Zhou, Xiaoxia Li, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signalling
In this study, we show the expression of the Ca2+‐permeable Piezo1 channel, a newly‐discovered mechanosensing mechanism, in human dental pulp‐derived MSC and its important role in the regulation of MSC migration. We further demonstrate that activation of the Piezo1 channel stimulates MSC migration via inducing ATP release and subsequent acti vation of P2 receptor purinergic signaling. Our study thus provide novel insights into the mechanisms regulating MSC migration. Such information is useful for gaining a better understanding of MSC migration and designing strategies to improve applications of MSC in tissue enginee...
Source: Stem Cells - November 18, 2019 Category: Stem Cells Authors: Fatema Mousawi, Hongsen Peng, Jing Li, Ponnambalam Sreenivasan, Sebastian Roger, Hucheng Zhao, Xuebin Yang, Lin ‐Hua Jiang Tags: Tissue ‐Specific Stem Cells Source Type: research

Markers of Accelerated Skeletal Muscle Regenerative Response in MRL/MpJ Mice: Characteristics of Muscle Progenitor Cells and Circulating Factors
This study suggests that a combination of MPCs and modulating antio xidative stress can represent a novel therapy to improve muscle healing after injury, disease, and aging.© AlphaMed Press 2018
Source: Stem Cells - December 10, 2018 Category: Stem Cells Authors: Chieh Tseng, Krishna Sinha, Haiying Pan, Yan Cui, Ping Guo, Chih Yi Lin, Fan Yang, Zhenhan Deng, Holger K. Eltzschig, Aiping Lu, Johnny Huard Tags: Regenerative Medicine Source Type: research

EDG5 plays an important role in induction and maintenance of pluripotency
Graphical abstract summarizing the main findings generated from this study. AbstractDirect reprogramming of human somatic cells toward induced pluripotent stem cells holds great promise for regenerative medicine and basic biology. We used a high ‐throughput siRNA screening assay in the initiation phase of reprogramming for 784 genes belonging to kinase and phosphatase families and identified 68 repressors and 22 effectors. Six new candidates belonging to the family of the G protein–coupled receptors (GPCRs) were identified suggesting an important role for this key signalling pathway during somatic cell induced reprogra...
Source: Stem Cells - December 4, 2018 Category: Stem Cells Authors: Irina Neganova, Lewis Cotts, Peter Banks, Katja Gassner, Lyle Armstrong, Graham Ladds, Majlinda Lako Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research