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Source: Endocrinology
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Total 17 results found since Jan 2013.

Functions of Membrane Progesterone Receptors (mPRs, PAQRs) in Nonreproductive Tissues
Endocrinology. 2022 Aug 30:bqac147. doi: 10.1210/endocr/bqac147. Online ahead of print.ABSTRACTGender differences in a wide variety of physiological parameters have implicated the ovarian hormones, estrogens and progesterone, in the regulation of numerous nonreproductive tissue functions. Rapid, nongenomic (nonclassical) progesterone actions mediated by membrane progesterone receptors (mPRs), which belong to the progestin and AdipoQ receptor (PAQR) family, have been extensively investigated in reproductive and nonreproductive tissues since their discovery in fish ovaries 20 years ago. The five mPR subtypes (α, β, γ, δ,...
Source: Endocrinology - August 30, 2022 Category: Endocrinology Authors: Peter Thomas Yefei Pang Maria Andrea Camilletti Luca F Castelnovo Source Type: research

An RNAi screening of clinically relevant transcription factors regulating human adipogenesis and adipocyte metabolism
CONCLUSIONS: This comprehensive RNAi screening in hASC suggests that a large proportion of WAT TFs that are impacted by metabolic conditions might be important for hyperplastic adipose tissue expansion. The screen also identified JARID2 as a novel TF essential for the development of functional adipocytes.PMID:33963396 | DOI:10.1210/endocr/bqab096
Source: Endocrinology - May 8, 2021 Category: Endocrinology Authors: Christel Bj örk Narmadha Subramanian Jianping Liu Juan Ramon Acosta Beatriz Tavira Anders B Eriksson Peter Arner Jurga Laurencikiene Source Type: research

Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Abstract Extracellular vesicles (EVs) are key players of intercellular communication in the physiological and pathological setting. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment (TME), and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anticancer agents, including antibodies, chemotherapy, compounds, CRISPR/Cas9 (clustere...
Source: Endocrinology - February 12, 2021 Category: Endocrinology Authors: Kugeratski FG, McAndrews KM, Kalluri R Tags: Endocrinology Source Type: research

Dihydrotestosterone increases cytotoxic activity of macrophages on prostate cancer cells via TRAIL.
Abstract Although androgen depravation therapy (ADT) and immunotherapy are potential treatment options in men with metastatic prostate cancer (CaP), androgen has conventionally been proposed to be a suppressor of the immune response. However, we herein report that dihydrotestosterone (DHT) activates macrophages. When the murine macrophage cell line (RAW 264.7), human monocyte (THP-1), and human peripheral blood monocytes were cultured with androgen-resistant CaP cell lines, DHT increased cytotoxicity of macrophages in a concentration-dependent manner. Further studies revealed that DHT induced M1 polarization and i...
Source: Endocrinology - June 10, 2019 Category: Endocrinology Authors: Lee GT, Kim JH, Kwon SJ, Stein MN, Hong JH, Nagaya N, Billakanti S, Kim MM, Kim WJ, Kim IY Tags: Endocrinology Source Type: research

Mechanism of Telapristone acetate (CDB4124) on Progesterone receptor action in breast cancer cells.
In conclusion, TPA decreases PR occupancy on chromatin, recruits co-regulators such as TRPS1 to the PR complex thereby regulates PR target gene expression and associated cellular responses. PMID: 30203004 [PubMed - as supplied by publisher]
Source: Endocrinology - September 6, 2018 Category: Endocrinology Authors: Davaadelger B, Murphy AR, Clare SE, Lee O, Khan SA, Kim JJ Tags: Endocrinology Source Type: research

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library.
This study is the first comprehensive analysis in discovering potential endocrine disrupters which affect the ERRα signaling pathway. PMID: 29216352 [PubMed - as supplied by publisher]
Source: Endocrinology - December 4, 2017 Category: Endocrinology Authors: Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M Tags: Endocrinology Source Type: research

Thyroid Hormone Receptor β (TRβ) Mediates Runt-Related Transcription Factor 2 (Runx2) Expression in Thyroid Cancer Cells: A novel signaling pathway in thyroid cancer.
Abstract Dysregulation of the thyroid hormone receptor β (TRβ) is common in human cancers. Restoration of functional TRβ delays tumor progression in models of thyroid and breast cancers implicating TRβ as a tumor suppressor. Conversely, aberrant expression of the runt-related transcription factor 2 (Runx2) is established in the progression and metastasis of thyroid, breast and other cancers. Silencing of Runx2 diminishes tumor invasive characteristics. With TRβ as a tumor suppressor and Runx2 as a tumor promoter, a compelling question is whether there is a functional relationship between these regulatory fact...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Carr FE, Tai PW, Barnum MS, Gillis NE, Evans KG, Taber TH, White JH, Tomczak JA, Jaworski DM, Zaidi SK, Lian JB, Stein JL, Stein GS Tags: Endocrinology Source Type: research

Endogenous IGFBP-3 mediates intrinsic apoptosis through modulation of Nur77 phosphorylation and nuclear export.
Abstract In non-transformed bovine mammary epithelial cells, the intrinsic apoptosis inducer anisomycin (ANS) induces IGFBP-3 expression and nuclear localization and knock-down of IGFBP-3 attenuates ANS-induced apoptosis. Others have shown in prostate cancer cells that exogenous IGFBP-3 induces apoptosis by facilitating nuclear export of the orphan nuclear receptor Nur77 and its binding partner retinoid X receptor-α (RXRα). The goal of the present work was to determine if endogenous IGFBP-3 plays a role in ANS-induced apoptosis by facilitating nuclear transport of Nur77 and/or RXRα in non-transformed cells. Kno...
Source: Endocrinology - September 4, 2015 Category: Endocrinology Authors: Agostini-Dreyer A, Jetzt AE, Stires H, Cohick WS Tags: Endocrinology Source Type: research

Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis.
Abstract Recently we discovered a cDNA in teleost ovarian follicle cells belonging to the zinc transporter ZIP9 subfamily encoding a protein with characteristics of a membrane androgen receptor (mAR). Here we demonstrate that human ZIP9 expressed in MDA-MB-468 breast cancer cells and stably over-expressed in human prostate cancer PC-3 cells (PC-3-ZIP9) also displays the ligand binding and signaling characteristics of a specific, high-affinity mAR. Testosterone treatment of MDA-MB-468 and PC-3-ZIP9 cells caused activation of G proteins and second messenger pathways as well as increases in intracellular free zinc co...
Source: Endocrinology - July 11, 2014 Category: Endocrinology Authors: Thomas P, Dong J, Berg AH, Pang Y Tags: Endocrinology Source Type: research

Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female Atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells.
We report here cloning and expression of a cDNA from Atlantic croaker (Micropogonias undulatus) ovaries encoding a 33 kDa, 7-transmembrane protein with binding and signaling characteristics of a membrane androgen receptor (mAR) that is unrelated to any previously described steroid receptor. Instead croaker mAR has 81-93% amino acid sequence identity with zinc transporter ZIP9 (SLC39A9) subfamily members, indicating it is a ZIP9 protein. Croaker ZIP9 is expressed in gonadal tissues and in brain, and is upregulated in the ovary by reproductive hormones. ZIP9 protein is localized to plasma membranes of croaker granulosa cells...
Source: Endocrinology - July 11, 2014 Category: Endocrinology Authors: Berg AH, Rice CD, Rahman MS, Dong J, Thomas P Tags: Endocrinology Source Type: research