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Source: Biomaterials

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Total 156 results found since Jan 2013.

Integrin binding and MAPK signal pathways in primary cell responses to surface chemistry of calcium silicate cements.
This study sheds light on the mechanism by which the modulation of the chemical composition of calcium silicate cements with different Si/Ca molar ratios could produce different cell responses. Two primary cell types (human mesenchymal stem cells (hMSCs) and human dental pulp cells (hDPCs)) were used to elicit the changes in total DNA content, integrin subunit levels, phosphor-focal adhesion kinase (pFAK) levels, and mitogen-activated protein kinase (MAPK) signaling pathway activity at the cell attachment stage. The effect of small interfering RNA (siRNA) transfection targeting collagen type I (COL I) and fibronectin (FN) ...
Source: Biomaterials - June 13, 2013 Category: Materials Science Authors: Shie MY, Ding SJ Tags: Biomaterials Source Type: research

Albumin-based nanoconjugates for targeted delivery of therapeutic oligonucleotides.
Abstract Nanoparticle-based delivery has become an important strategy to advance siRNA and antisense oligonucleotides into clinical reality. However, limited biodistribution of nanoparticles and the toxicity of some nanocarriers restrict the wider application of this strategy. To address these issues we aimed to construct oligonucleotide delivery systems which are non-cytotoxic and smaller than typical nanoparticles. Thus, a morpholino oligonucleotide was conjugated to a tumor-targeting RGD peptide, and then, multiple RGD-oligo conjugates were linked to a single molecule of human serum albumin via a reductively re...
Source: Biomaterials - July 19, 2013 Category: Materials Science Authors: Ming X, Carver K, Wu L Tags: Biomaterials Source Type: research

Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity.
In this study we synthesized lipid unilamellar nanoparticles (NPs) that can selectively deliver Kv1.3 siRNAs into TM cells in vitro. NPs made from a mixture of phosphatidylcholine, pegylated/biotinylated phosphoethanolamine and cholesterol were functionalized with biotinylated-CD45RO (cell surface marker of TM's) antibodies via fluorophore-conjugated streptavidin (CD45RO-NPs). Incubation of T cells with CD45RO-NPs resulted into the selective attachment and endocytosis of the NPs into TM's. Furthermore, the siRNA against Kv1.3, encapsulated into the CD45RO-NPs, was released into the cytosol. Consequently, the expression of...
Source: Biomaterials - September 26, 2013 Category: Materials Science Authors: Hajdu P, Chimote AA, Thompson TH, Koo Y, Yun Y, Conforti L Tags: Biomaterials Source Type: research

Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells.
We report programmed nanoparticles (pNPs) that can tailor the immunotherapeutic function of primary bone marrow-derived dendritic cells (BMDCs) by ex vivo combined immunomodulation and track the in vivo migration of them after injection into body. Because DCs are the most effective antigen-presenting cells (APCs) that are able to present the antigens to T cells that contribute to tumor rejection, the maturation and monitoring of therapeutic DCs are essential for the efficient cancer immunotherapy. For combined immunomodulation of DCs, poly (lactic-co-glycolic acid) (PLGA) NPs containing both small interfering RNA (siRNA)...
Source: Biomaterials - October 11, 2013 Category: Materials Science Authors: Heo MB, Lim YT Tags: Biomaterials Source Type: research

A review of ligand tethered surface engineered carbon nanotubes.
Abstract Carbon nanotubes (CNTs) have emerged as fascinating materials, exhibiting promising potential in receptor based targeting owing to their unique physicochemical properties (cell membrane penetration, high surface area and drug payload, biocompatibility, easy surface modification, photoluminescence property, and non-immunogenicity etc). The hydrophilicity, a major constrain associated with the first generation of CNTs i.e. pristine CNTs, could be overcome using functionalization techniques. In the last two decades variety of functionalized CNTs (f-CNTs) i.e. oxidized, amidated, acylated, surfactant and biop...
Source: Biomaterials - November 6, 2013 Category: Materials Science Authors: Mehra NK, Mishra V, Jain NK Tags: Biomaterials Source Type: research

Molecular modeling of polynucleotide complexes.
Abstract Delivery of polynucleotides into patient cells is a promising strategy for treatment of genetic disorders. Gene therapy aims to either synthesize desired proteins (DNA delivery) or suppress expression of endogenous genes (siRNA delivery). Carriers constitute an important part of gene therapeutics due to limitations arising from the pharmacokinetics of polynucleotides. Non-viral carriers such as polymers and lipids protect polynucleotides from intra and extracellular threats and facilitate formation of cell-permeable nanoparticles through shielding and/or bridging multiple polynucleotide molecules. Format...
Source: Biomaterials - May 21, 2014 Category: Materials Science Authors: Meneksedag-Erol D, Tang T, Uludağ H Tags: Biomaterials Source Type: research

Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed lethal cancers in the world. We previously showed two imidazolium salts (IBN-1 and IBN-9) with a moderate efficacy for HCC. Here we report a more potent imidazolium compound IBN-65 (1-benzyl-2-phenyl-3-(4-isopropyl)-benzyl-imidazolium chloride) and the associated mechanisms of action in a mouse model of HCC. The IC50 of this compound in various liver cancer cell lines was around 5 μm. IBN-65 dose-dependently arrested cell cycle at G1 phase and was associated with the down-regulation of the cyclin-dependent kinase-4, -6, cyclin D1, and ...
Source: Biomaterials - June 6, 2014 Category: Materials Science Authors: Gopalan B, Narayanan K, Ke Z, Lu T, Zhang Y, Zhuo L Tags: Biomaterials Source Type: research

Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes.
Abstract Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular cell types. This guided transport aims to enhance the NP accumulation in the tumor and moreover enhance the infiltration of regions that are typically inaccessible for free NPs. Within this study, cytotoxic CD8(+) T cells were selected as carriers based on both their ability to migrate to the tumor and their intrinsic cyto...
Source: Biomaterials - November 10, 2015 Category: Materials Science Authors: Wayteck L, Dewitte H, De Backer L, Breckpot K, Demeester J, De Smedt SC, Raemdonck K Tags: Biomaterials Source Type: research

Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition.
This study suggests that enhanced tumor penetration of drug-carrying nanoparticles can enhance CSCs clearance in vivo and consequently provide superior anti-tumor effects. PMID: 26751819 [PubMed - as supplied by publisher]
Source: Biomaterials - December 21, 2015 Category: Materials Science Authors: Zuo ZQ, Chen KG, Yu XY, Zhao G, Shen S, Cao ZT, Luo YL, Wang YC, Wang J Tags: Biomaterials Source Type: research

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.
Abstract Desmoplasia is a hallmark of pancreatic cancer and consists of fibrotic cells and secreted extracellular matrix (ECM) components. Various in vitro three-dimensional (3D) models of desmoplasia have been reported, but little is known about the relevant thickness of the engineered fibrotic tissue. We thus measured the thickness of fibrotic tissue in human pancreatic cancer, as defined by the distance from the blood vessel wall to tumor cells. We then generated a 3D fibrosis model with a thickness reaching the clinically observed range using pancreatic stellate cells (PSCs), the main cellular constituent of p...
Source: Biomaterials - November 17, 2018 Category: Materials Science Authors: Tanaka HY, Kitahara K, Sasaki N, Nakao N, Sato K, Narita H, Shimoda H, Matsusaki M, Nishihara H, Masamune A, Kano MR Tags: Biomaterials Source Type: research

Auto-fluorescent polymer nanotheranostics for self-monitoring of cancer therapy via triple-collaborative strategy.
Abstract Aberrant regulation of angiogenesis supply sufficient oxygen and nutrients to exacerbate tumor progression and metastasis. Taking this hallmark of cancer into account, reported here is a self-monitoring and triple-collaborative therapy system by auto-fluorescent polymer nanotheranostics which could be concurrently against angiogenesis and tumor cell growth by combining the benefits of anti-angiogenesis, RNA interfere and photothermal therapy (PTT). Auto-fluorescent amphiphilic polymer polyethyleneimine-polylactide (PEI-PLA) with positive charge can simultaneously load hydrophobic antiangiogenesis agent co...
Source: Biomaterials - December 20, 2018 Category: Materials Science Authors: Shao L, Li Q, Zhao C, Lu J, Li X, Chen L, Deng X, Ge G, Wu Y Tags: Biomaterials Source Type: research

PEGylation of poly(amine-co-ester) polyplexes for tunable gene delivery
Biomaterials. 2021 Mar 24;272:120780. doi: 10.1016/j.biomaterials.2021.120780. Online ahead of print.ABSTRACTThere is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in order to improve vehicle stability and reduce toxicity, but little is known about the effects of PEG coatings on transfection. We used a polymer from the poly(amine-co-ester) (PACE) family blended with PEG-conjugated PACE at different ratios in order to explore the effects of polyplex PEGylation on the transfection efficiency of plasmid DNA, mRNA, and siRNA in vitro and mRNA in vivo. We discovered that concentrations of PACE-...
Source: Biomaterials - April 4, 2021 Category: Materials Science Authors: Molly K Grun Alexandra Suberi Kwangsoo Shin Teresa Lee Victoria Gomerdinger Zoe M Moscato Alexandra S Piotrowski-Daspit W Mark Saltzman Source Type: research

Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues
This study delineates the mechanism of compression-induced cytoskeleton reorganization, contributing to rationalizing mechanical loading regimes for functional tissue engineering.PMID:33933985 | DOI:10.1016/j.biomaterials.2021.120829
Source: Biomaterials - May 2, 2021 Category: Materials Science Authors: Vincent Kwok Lim Lam Johnny Yu Hin Wong Sing Yian Chew Barbara Pui Chan Source Type: research

Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis
Biomaterials. 2021 Jun 24;275:120988. doi: 10.1016/j.biomaterials.2021.120988. Online ahead of print.ABSTRACTPD-L1/PD-1 blockade therapy shows durable responses to triple-negative breast cancer (TNBC), but the response rate is low. CD155 promotes tumor metastasis intrinsically and modulates the immune response extrinsically as the ligand of DNAM-1 (costimulatory receptor) and TIGIT/CD96 (coinhibitory receptors). Herein, we verified that TNBC cells coexpressed PD-L1 and CD155. By examining the receptors of PD-L1 and CD155 on TNBC tumor-infiltrating lymphocytes (TILs) over time, we observed that PD-1 and DNAM-1 were upregula...
Source: Biomaterials - June 29, 2021 Category: Materials Science Authors: Chuanrong Chen Qianqian Guo Hao Fu Jian Yu Liting Wang Ying Sun Jiali Zhang Yourong Duan Source Type: research