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Source: Biomaterials
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Total 156 results found since Jan 2013.
Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis
Biomaterials. 2022 Mar 29;284:121492. doi: 10.1016/j.biomaterials.2022.121492. Online ahead of print.ABSTRACTHepatic stellate cell (HSC)-targeted delivery is an attractive strategy for liver fibrosis therapy, but the efficacy is hampered by poor delivery of nanomaterials and complicated microenvironments of the fibrotic liver. Here, we report a versatile CXCR4-inhibiting nanocomplex composed of polymeric CXCR4 antagonism (PAMD, PA), CLD (clodronate) and siPAI-1 (siRNA of plasminogen activator inhibitor-1) that surmounts multiple barriers to improve the outcome by co-regulating Kupffer cells (KCs), extracellular matrix (ECM...
Source: Biomaterials - April 8, 2022 Category: Materials Science Authors: Pengkai Wu Xinping Luo Meiling Sun Beicheng Sun Minjie Sun Source Type: research
Inhibition of SerpinB9 to enhance granzyme B-based tumor therapy by using a modified biomimetic nanoplatform with a cascade strategy
In this study, it was proved that SerpinB9 (Sb9) downregulation can enhance the GrB susceptibility of tumor cells. Moreover, a nanocarrier fused with M1 macrophage exosomes (M1 Exo) and photothermal sensitive liposomes was constructed to efficiently transport GrB and siRNA of Sb9 to the cells. The nanocarrier is characterized by cascade tumor targeting acquired by photothermal effect-triggered increased expression of vascular cell adhesion molecule-1 (VCAM-1) in tumor tissue. Furthermore, the innate cytokines in M1 Exo are capable of regulating the tumor microenvironment by repolarizing M2 macrophages to the M1 type. Colle...
Source: Biomaterials - August 13, 2022 Category: Materials Science Authors: Ran Han Luting Yu Chenxuan Zhao Ying Li Yuying Ma Yuewen Zhai Zhiyu Qian Yueqing Gu Siwen Li Source Type: research
Corrigendum to "Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy" Biomater. 234 (2020) 119760
Biomaterials. 2022 Dec 14;293:121951. doi: 10.1016/j.biomaterials.2022.121951. Online ahead of print.NO ABSTRACTPMID:36525705 | DOI:10.1016/j.biomaterials.2022.121951
Source: Biomaterials - December 16, 2022 Category: Materials Science Authors: Senlin Li Phei Er Saw Chunhao Lin Yan Nie Wei Tao Omid C Farokhzad Lei Zhang Xiaoding Xu Source Type: research
Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
Biomaterials. 2023 Jan 21;294:122016. doi: 10.1016/j.biomaterials.2023.122016. Online ahead of print.ABSTRACTTargeted delivery of oligonucleotides or small molecular drugs to hepatocytes, the liver's parenchymal cells, is challenging without targeting moiety due to the highly efficient mononuclear phagocyte system (MPS) of the liver. The MPS comprises Kupffer cells and specialized sinusoidal endothelial cells, efficiently clearing nanocarriers regardless of their size and surface properties. Physiologically, this non-parenchymal shield protects hepatocytes; however, these local barriers must be overcome for drug delivery. ...
Source: Biomaterials - January 26, 2023 Category: Materials Science Authors: WanLing Foo Zolt án Cseresnyés Carsten R össel Yingfeng Teng Anuradha Ramoji Mingzhe Chi Walter Hauswald Sophie Huschke Stephanie Hoeppener J ürgen Popp Felix H Schacher Marek Sierka Marc Thilo Figge Adrian T Press Michael Bauer Source Type: research
