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Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth.
Abstract The placenta exchanges nutrients between the mother and the fetus, and requires a constant abundant energy supply. Adiponectin (a cytokine produced primarily by adipose tissue) controls glucose and lipid homeostasis. It is well known that maternal serum adiponectin levels are inversely related to birth weight suggesting that adiponectin has a negative effect on fetal growth. This effect appears to be related to the control of nutrient transporters in human placenta. However, the underlying molecular mechanisms have not yet been characterized. In the present work, we studied adiponectin's direct effect on ...
Source: Biology of Reproduction - March 29, 2016 Category: Reproduction Medicine Authors: Duval F, Dos Santos E, Poidatz D, Sérazin V, Gronier H, Vialard F, Dieudonné MN Tags: Biol Reprod Source Type: research