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Source: Toxicology and Applied Pharmacology
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Total 118 results found since Jan 2013.
Involvement of m6A regulatory factor IGF2BP1 in malignant transformation of human bronchial epithelial Beas-2B cells induced by tobacco carcinogen NNK
This study therefore contributes novel insights into the environmental pathogenesis of lung cancer and the gene regulatory mechanisms of chemical carcinogenesis.PMID:34974052 | DOI:10.1016/j.taap.2021.115849
Source: Toxicology and Applied Pharmacology - January 2, 2022 Category: Toxicology Authors: Jiaxin Zhou Rui Xiong Jiazhen Zhou Xinchao Guan Guanqing Jiang Yuyang Chen Qiaoyuan Yang Source Type: research
The exosome-circ_0001359 derived from cigarette smoke exposed-prostate stromal cells promotes epithelial cells collagen deposition and primary ciliogenesis
In this study, human prostate epithelial RWPE-1 cells were co-cultured with exosomes derived from CS exposed-WPMY-1 cells (CS-WPMY-1-exo). The collagen deposition, primary ciliogenesis, epithelial-mesenchymal transition (EMT) and transforming growth factor (TGF)-β1 level of RWPE-1 were evaluated. The circRNAs profiles of WPMY-1-exo were explored by high-throughput RNA sequencing. It was found that CS-WPMY-1-exo significantly promoted RWPE-1 collagen deposition, EMT and primary ciliogenesis. There were 17 differentially expressed (DE) circRNAs (including circ_0001359) between CS-WPMY-1-exo and the negative control. Functio...
Source: Toxicology and Applied Pharmacology - December 30, 2021 Category: Toxicology Authors: Jinglou Chen Nan Rong Min Liu Congyue Xu Jing Guo Source Type: research
Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic
Toxicol Appl Pharmacol. 2021 Nov 16;434:115799. doi: 10.1016/j.taap.2021.115799. Online ahead of print.ABSTRACTArsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact of other DNA-damaging agents, such as ultraviolet radiation (UVR). Arsenic exposure leads to oxidation of zinc coordinating cysteine residues, zinc loss and decreased activity of the DNA repair protein poly(ADP)ribose polymerase (PARP)-1. Because arsenic stimulates NA...
Source: Toxicology and Applied Pharmacology - November 19, 2021 Category: Toxicology Authors: Karen L Cooper Lindsay B Volk Dayna R Dominguez Antonia D Duran K J Ke Jian Liu Laurie G Hudson Source Type: research
Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3
Toxicol Appl Pharmacol. 2021 Nov 12:115795. doi: 10.1016/j.taap.2021.115795. Online ahead of print.ABSTRACTA chronic liver disease named autoimmune hepatitis (AIH) will carry elevated levels of inflammatory cytokines, but there is currently no effective treatment to cure it. Histone deacetylase 3 (HDAC3) takes an important position in regulating the expression of inflammatory genes. Nimbolide (NIB) is a limonoid extracted from the neem tree (Azadirachta indica) that has been found to be effective against many diseases, including cancer, scleroderma, and acute respiratory distress syndrome. Here, we investigated the protect...
Source: Toxicology and Applied Pharmacology - November 15, 2021 Category: Toxicology Authors: Dingchao Xia Dazhi Chen Tingchen Cai Lujian Zhu Yanhan Lin Sijie Yu Kailu Zhu Xiaodong Wang Lanman Xu Yongping Chen Source Type: research
Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3
In conclusion, CAR suppressed lipid accumulation, mitochondrial dysfunction and hepatocyte apoptosis by activating PRDX3, mitigating the progression of NAFLD, and thus, CAR may represent a promising candidate for clinical treatment of steatosis.PMID:34678374 | DOI:10.1016/j.taap.2021.115758
Source: Toxicology and Applied Pharmacology - October 22, 2021 Category: Toxicology Authors: Yunfei Geng Yue Wang Ruimin Sun Xiaohui Kang Huanyu Zhao Meiyang Zhu Yu Sun Yan Hu Zhecheng Wang Xiaofeng Tian Yan Zhao Jihong Yao Source Type: research
The role of microRNAs in regulating cadmium-induced apoptosis by targeting Bcl-2 in IEC-6 cells
This study evaluated the effects of Cd exposure (0, 0.25, 0.5, 1, 2, and 4 μM) on IEC-6 cells in terms of cell viability and apoptosis, as well as apoptosis-associated gene expression. The results indicated that low doses (0.25- 1 μM) of Cd exhibited hormetic effects, while high doses of Cd (2 and 4 μM) reduced cell viability. The apoptotic effect increased in a dose-dependent pattern. Moreover, the mRNA levels of the Bcl-2, Bax and Caspase 3 genes were altered, which was in agreement with their protein expression. Based on sequencing analysis, the expression pattern of the microRNAs (miRNAs) changed significantly in th...
Source: Toxicology and Applied Pharmacology - October 18, 2021 Category: Toxicology Authors: Jinsong Yang Wei Chen Yi Sun Pincang Xia Jin Liu Wenchang Zhang Source Type: research
Exposure of silver nanocolloids causes glycosylation disorders and embryonic deformities in medaka
This study addressed the glycobiological effects of SNC exposure on medaka embryogenesis. After exposure of medaka embryos to SNC, deformities such as small heads and deformed eyes were observed. The expression of five glycan-related genes (alg2, gnsb, b4galt2, b3gat1a, and b3gat2) was significantly altered, with changes depending on the embryonic stage at exposure, with more severe deformities with exposure at earlier stages. In situ hybridization analyses indicated that the five genes were expressed mainly in the head region; exposure of SNC suppressed alg2 and gnsb and enhanced b4galt2 and b3gat1a expression relative to...
Source: Toxicology and Applied Pharmacology - September 20, 2021 Category: Toxicology Authors: Kaori Shimizu Daisuke Kotajima Kensuke Fukao Futaba Mogi Risa Horiuchi Chisato Kataoka Yoshihiro Kagami Misato Fujita Nobumitsu Miyanishi Shosaku Kashiwada Source Type: research
