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Source: Experimental Cell Research
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Total 221 results found since Jan 2013.
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway
Exp Cell Res. 2022 Apr 26:113179. doi: 10.1016/j.yexcr.2022.113179. Online ahead of print.ABSTRACTRab22a, a member of the proto-oncogene RAS family, belongs to the Rab5 subfamily. It participates in early endosome formation and regulates vesicle trafficking. The relationship between Rab22a and tumorigenesis remains elusive. In non-small cell lung cancer specimens, immunohistochemical staining showed consistently high expression of Rab22a in lung adenocarcinoma, but not in squamous cell carcinoma. In lung adenocarcinoma cell lines, A549 and H1299, transfection with Rab22a significantly promoted cell proliferation, migration...
Source: Experimental Cell Research - April 29, 2022 Category: Cytology Authors: Jinping Wang Xue Luo Jinxi Lu Xi Wang Yuan Miao Qingchang Li Liang Wang Source Type: research
CYP27A1 inhibits proliferation and migration of clear cell renal cell carcinoma via activation of LXRs/ABCA1
Exp Cell Res. 2022 Jul 7:113279. doi: 10.1016/j.yexcr.2022.113279. Online ahead of print.ABSTRACTCholesterol homeostasis plays an important role in the maintenance of normal body functions. CYP27A1 is a key enzyme known to regulate cholesterol homeostasis, which catalyzes the conversion of cholesterol to 27-HC and has been implicated in the occurrence and metastasis of various cancer types. The present study aimed to explore the regulatory role of CYP27A1 in the development of clear cell renal cell carcinoma (ccRCC). In particular, the effect of CYP27A1 on the proliferation and migration of ccRCC cells was investigated. Th...
Source: Experimental Cell Research - July 10, 2022 Category: Cytology Authors: Zhijuan Liang Wei Jiao Liping Wang Yuanbin Chen Dan Li Zhao Zhang Zhilei Zhang Ye Liang Haitao Niu Source Type: research
Inhibition of TRPC6 suppressed TGF β-induced fibroblast-myofibroblast transdifferentiation in renal interstitial NRK-49F cells
In conclusion, we demonstrate that TRPC6 is a key regulator of TGF-β1-induced fibroblast-myofibroblast transdifferentiation and provides the mechanism of how TGF-β1 exposure regulates TRPC6 expression in NRK-49F fibroblasts.PMID:36206825 | DOI:10.1016/j.yexcr.2022.113374
Source: Experimental Cell Research - October 7, 2022 Category: Cytology Authors: Shan Jiang Lifei Gu Yixin Hu Younan Ren Zhao Yang Chengzhi Chai Boyang Yu Haitao Ge Zhengyu Cao Fang Zhao Source Type: research
Back to basics: Optimization of DNA and RNA transfer in muscle cells using recent transfection reagents
In conclusion, we reported yet uncharacterized transfection reagents that can serve as a suitable low-cost alternative to the current gold standard in C2C12 cells.PMID:36273532 | DOI:10.1016/j.yexcr.2022.113392
Source: Experimental Cell Research - October 23, 2022 Category: Cytology Authors: Ilaria Cocchiararo M élanie Cornut Hadrien Soldati Alessandro Bonavoglia Perrine Castets Source Type: research
Silencing FHL2 inhibits bleomycin-induced pulmonary fibrosis through the TGF- β1/Smad signaling pathway
CONCLUSION: Inhibition of FHL2 can effectively reduce the fibrosis process induced by TGF⁃β1 and bleomycin, and then inhibit the fibrosis.PMID:36641135 | DOI:10.1016/j.yexcr.2023.113470
Source: Experimental Cell Research - January 14, 2023 Category: Cytology Authors: Mengkun Shi Huixia Cui Jialun Shi Yunqing Mei Source Type: research
Effects of Semaphorin3A on the growth of sensory and motor neurons
Exp Cell Res. 2023 Feb 8:113506. doi: 10.1016/j.yexcr.2023.113506. Online ahead of print.ABSTRACTAfter peripheral nerve injury, motor and sensory axons can regenerate, but the inaccurate reinnervation of the target leads to poor functional recovery. Schwann cells (SCs) express sensory and motor phenotypes associated with selective regeneration. Semaphorin 3A (Sema3A) is an axonal chemorepellent that plays an essential role in axon growth. SCs can secret Sema3A, and Sema3A presents a different expression pattern at the proximal and distal ends of injured sensory and motor nerves. Hence, in our study, the protein expression ...
Source: Experimental Cell Research - February 10, 2023 Category: Cytology Authors: Mi Shen Chun Zhou Yingchao Tian Tongxin Shang None Qingyun Liang Mengru Ming Fei Ding Yuhua Ji Source Type: research
Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
Exp Cell Res. 2023 Mar 7:113542. doi: 10.1016/j.yexcr.2023.113542. Online ahead of print.ABSTRACTEndothelial cell senescence is involved in endothelial dysfunction and aging-related vascular diseases. The D1-like dopamine receptor (DR1), a number of G-protein-coupled receptors, is currently under consideration as a potential therapeutic target for the prevention of atherosclerosis. However, the role of DR1 in regulating ox-LDL-stimulated endothelial cell senescence remains unknown. Here, we found that the elevated Prx hyperoxidation and reactive oxygen species (ROS) levels in ox-LDL-treated Human umbilical vein endothelial...
Source: Experimental Cell Research - March 9, 2023 Category: Cytology Authors: Yiming Zhao Yuxia Li Hongxia Li Sa Shi Source Type: research
USP7 reduction leads to developmental failure of mouse early embryos
Exp Cell Res. 2023 Apr 18:113605. doi: 10.1016/j.yexcr.2023.113605. Online ahead of print.ABSTRACTAs a member of Ubiquitin-specific protease subfamily, ubiquitin specific protease 7 (USP7) has been reported to participate in a variety of cellular processes, including cell cycle, apoptosis, DNA damage response, and epigenetic modification. However, its function in preimplantation embryos is still obscure. To investigate the functions of USP7 during preimplantation embryo development, we used siRNA to degrade endogenous USP7 messenger RNA. We found that USP7 knockdown significantly decreased the development rate of mouse ear...
Source: Experimental Cell Research - April 18, 2023 Category: Cytology Authors: Xue Zhang Xue-Feng Xie Ang Li Wei Song Chao Li Fei Li Xiao-Zhen Li Xiao-Yan Fan Chang-Yin Zhou Guang Wang Qing-Yuan Sun Xiang-Hong Ou Source Type: research
