Filtered By:
Source: Biochemical Pharmacology

This page shows you your search results in order of date. This is page number 10.

Order by Relevance | Date

Total 204 results found since Jan 2013.

Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: critical role of PPAR- γ signaling pathway.
Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: critical role of PPAR-γ signaling pathway. Biochem Pharmacol. 2017 Jul 27;: Authors: Choi MJ, Lee EJ, Park JS, Kim SN, Park EM, Kim HS Abstract Since microglia-associated neuroinflammation plays a pivotal role in the progression of neurodegenerative diseases, controlling microglial activation has been suggested as a potential therapeutic strategy. Here, we investigated the anti-inflammatory effects of galangin (3,5,7-trihydroxyflavone) in microglia and analyzed the underlying molecular mechanisms. Galangin inhibited t...
Source: Biochemical Pharmacology - July 27, 2017 Category: Drugs & Pharmacology Authors: Choi MJ, Lee EJ, Park JS, Kim SN, Park EM, Kim HS Tags: Biochem Pharmacol Source Type: research

The Neurotoxicant PCB-95 By Increasing the Neuronal Transcriptional Repressor REST Down-Regulates Caspase-8 and Increases Ripk1, Ripk3 and Mlkl Expression Determining Necroptotic Neuronal Death.
Abstract Our previous study showed that the environmental neurotoxicant non-dioxin-like polychlorinated biphenyl (PCB)-95 increases RE1-Silencing Transcription Factor (REST) expression, which is related to necrosis, but not apoptosis, of neurons. Meanwhile, necroptosis is a type of a programmed necrosis that is positively regulated by receptor interacting protein kinase 1 (RIPK1), RIPK3 and mixed lineage kinase domain-like (MLKL) and negatively regulated by caspase-8. Here we evaluated whether necroptosis contributes to PCB-95-induced neuronal death through REST up-regulation. Our results demonstrated that in cort...
Source: Biochemical Pharmacology - July 1, 2017 Category: Drugs & Pharmacology Authors: Guida N, Laudati G, Serani A, Mascolo L, Molinaro P, Montuori P, Di Renzo G, Mt Canzoniero L, Formisano L Tags: Biochem Pharmacol Source Type: research

Wnt/ β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.
The objective of the present study was to explore the potential functions of α7-nAChRs in PD pathology, and to determine whether these effects are exerted via Wnt/β-catenin signaling in a mouse PD model. In the in vivo study, α7-nAChR knockout (α7-KO) reversed the beneficial effects of nicotine on motor deficits, dopaminergic neuron loss, astrocyte and microglia activation, and reduced striatal dopamine release induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Injury to SH-SY5Y cells by 1-methyl-4-phenylpyridinium treatment was also ameliorated by nicotine, and this effect was abolished by methyllycaconitine (ML...
Source: Biochemical Pharmacology - May 24, 2017 Category: Drugs & Pharmacology Authors: Liu Y, Hao S, Yang B, Fan Y, Qin X, Chen Y, Hu J Tags: Biochem Pharmacol Source Type: research

Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.
CONCLUSION AND IMPLICATIONS: Our study suggested that the anti-arthritis effects of CTS were attained through suppression of p300-mediated STAT3 acetylation. Our data suggest that CTS might be a potential immune modulator for RA treatment. PMID: 28522406 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - May 15, 2017 Category: Drugs & Pharmacology Authors: Wang Y, Zhou C, Gao H, Li C, Li D, Liu P, Huang M, Shen X, Liu L Tags: Biochem Pharmacol Source Type: research

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.
In conclusion, this study describes that decrease of PXR expression levels and ligand-dependent activation of PXR and LXR increase hepatic SMPDL3A levels, which possibly connects these receptors to hepatic purinergic signaling and phospholipid metabolism and may result in drug-drug interactions with phosphoramidate pro-drugs. PMID: 28414139 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O Tags: Biochem Pharmacol Source Type: research

Axl molecular targeting counteracts aggressiveness but not platinum-resistance of ovarian carcinoma cells.
Abstract Ovarian carcinoma, the most common gynecological cancer, is characterized by high lethality mainly due to late diagnosis and treatment failure. The efficacy of platinum drug-based therapy in the disease is limited by the occurrence of drug resistance, a phenomenon often associated with increased metastatic potential. Because the Tyr-kinase receptor Axl can be deregulated in ovarian carcinoma and plays a pro-metastatic/anti-apoptotic role, the aim of this study was to examine if Axl inhibition modulates drug resistance and aggressive features of ovarian carcinoma cells, using various pairs of cisplatin-sen...
Source: Biochemical Pharmacology - April 9, 2017 Category: Drugs & Pharmacology Authors: Corno C, Gatti L, Arrighetti N, Carenini N, Zaffaroni N, Lanzi C, Perego P Tags: Biochem Pharmacol Source Type: research

H2S-induced S-sulfhydration of lactate dehydrogenase A (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells.
Abstract Cystathionine-β-synthase (CBS) is upregulated and hydrogen sulfide (H2S) production is increased in colon cancer cells. The functional consequence of this response is stimulation of cellular bioenergetics and tumor growth and proliferation. Lactate dehydrogenase A (LDHA) is also upregulated in various colon cancer cells and has been previously implicated in tumor cell bioenergetics and proliferation. In the present study, we sought to determine the potential interaction between the H2S pathway and LDH activity in the control of bioenergetics and proliferation of colon cancer, using the colon cancer line ...
Source: Biochemical Pharmacology - April 9, 2017 Category: Drugs & Pharmacology Authors: Untereiner AA, Oláh G, Módis K, Hellmich MR, Szabo C Tags: Biochem Pharmacol Source Type: research

Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF- κB in human rheumatoid arthritis synovial fibroblasts.
Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 2017 Mar 10;: Authors: Yang CM, Chen YW, Chi PL, Lin CC, Hsiao LD Abstract Bradykinin (BK) induces inflammation in rheumatoid arthritis (RA). Resveratrol is a potent activator of Sirt1 which could modulate inflammation through deacetylating histones of transcription factors. Here, we investigated the mechanisms underlying BK-induced COX-2 expression which is modulated by resveratrol/Sirt1 in human rheumatoid arthritis synovial fibrobla...
Source: Biochemical Pharmacology - March 9, 2017 Category: Drugs & Pharmacology Authors: Yang CM, Chen YW, Chi PL, Lin CC, Hsiao LD Tags: Biochem Pharmacol Source Type: research

Protein kinase CK2 α catalytic subunit ameliorates diabetic renal inflammatory fibrosis via NF-κB signaling pathway.
This study indicates the essential role of CK2α in regulating the diabetic renal pathological process of inflammatory fibrosis via NF-κB pathway, and inhibition of CK2α may serve as a promising therapeutic strategy for diabetic nephropathy. PMID: 28237649 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 21, 2017 Category: Drugs & Pharmacology Authors: Huang J, Chen Z, Li J, Chen Q, Li J, Gong W, Huang J, Liu P, Huang H Tags: Biochem Pharmacol Source Type: research

Role for Human arylamine N-acetyltransferase 1 in the methionine salvage pathway.
Abstract The Phase II drug metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) has been implicated in the growth and survival of cancer cells, although the mechanisms that underlies these effects are unknown. Here, a focused metabolomics approach was used to identify changes in folate catabolism as well as the S-adenosylmethionine (SAM) cycle following NAT1 knockdown with shRNA. Although acetylation of the folate catabolite p-aminobenzoylglutamate (pABG) was significantly decreased, there were no changes in intracellular pABG or the various components of the SAM cycle. By contrast, the flux of homocysteine ...
Source: Biochemical Pharmacology - November 15, 2016 Category: Drugs & Pharmacology Authors: Witham KL, Minchin RF, Butcher NJ Tags: Biochem Pharmacol Source Type: research

Salinomycin enhances cisplatin-induced cytotoxicity in human lung cancer cells via down-regulation of AKT-dependent thymidylate synthase expression.
In this study, we showed that salinomycin (0.5 - 2 μg/mL) treatment down-regulating of TS expression in an AKT inactivation manner in two NSCLC cell lines, human lung adenocarcinoma A549 and squamous cell carcinoma H1703 cells. Knockdown of TS using small interfering RNA (siRNA) or inhibiting AKT activity with PI3K inhibitor LY294002 enhanced the cytotoxicity and cell growth inhibition of salinomycin. A combination of cisplatin and salinomycin resulted in synergistic enhancement of cytotoxicity and cell growth inhibition in NSCLC cells, accompanied with reduced activation of phospho-AKT, and TS expression. Overexpression ...
Source: Biochemical Pharmacology - September 21, 2016 Category: Drugs & Pharmacology Authors: Ko JC, Zheng HY, Chen WC, Peng YS, Wu CH, Wei CL, Chen JC, Lin YW Tags: Biochem Pharmacol Source Type: research

Targeting GH-1 Splicing as a Novel Pharmacological Strategy for Growth Hormone Deficiency Type II.
Abstract Isolated Growth Hormone Deficiency type II (IGHD II) is a rare genetic splicing disorder characterized by reduced growth hormone (GH) secretion and short stature. It is mainly caused by autosomal dominant-negative mutations within the growth hormone gene (GH-1) which result in missplicing at the mRNA level and the subsequent loss of exon 3, producing the 17.5-kDa GH isoform: a mutant and inactive GH protein that reduces the stability and the secretion of the 22-kDa GH isoform, the main biologically active GH form. At present, patients suffering from IGHD II are treated with daily injections of recombinant...
Source: Biochemical Pharmacology - July 21, 2016 Category: Drugs & Pharmacology Authors: Miletta MC, Flück CE, Mullis PE Tags: Biochem Pharmacol Source Type: research

Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide.
Abstract Extracellular adenosine formation from ATP is controlled by ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase/CD39) and ecto-5'-nucleotidase (e-5NT/CD73); the latter converts AMP to adenosine and inorganic phosphate, representing the rate limiting step controlling the ratio between extracellular ATP and adenosine. Evidence that cellular expression and activity of CD39 and CD73 may be subject to changes under pathophysiological conditions has identified this pathway as an endogenous modulator in several diseases and was shown to be involved in the molecular mechanism of drugs, such as methotrexate...
Source: Biochemical Pharmacology - May 13, 2016 Category: Drugs & Pharmacology Authors: Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, Lavecchia A, Parenti A, Iuvone T, Schrader J, Ialenti A, Cicala C Tags: Biochem Pharmacol Source Type: research

Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.
In conclusion, PPARβ/δ activation restored the LPS-induced endothelial dysfunction by upregulation of UCP2, with the subsequent alleviation of ER stress and NADPH oxidase activity, thus reducing intracellular ROS production and increasing NO bioavailability. PMID: 27179975 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - May 10, 2016 Category: Drugs & Pharmacology Authors: Toral M, Romero M, Jiménez R, Robles-Vera I, Tamargo J, Carmen Martínez M, Pérez-Vizcaíno F, Duarte J Tags: Biochem Pharmacol Source Type: research

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.
Abstract Bromodomain-containing proteins are vital for controlling the expression of many pro-inflammatory genes. Consequently, compounds capable of inhibiting specific bromodomain-facilitated protein-protein interactions would be predicted to alleviate inflammation, making them valuable agents in the treatment of diseases caused by dysregulated inflammation, such as age-related macular degeneration. Here, we assessed the ability of known inhibitors JQ-1, PFI-1, and IBET-151 to protect from the inflammation and cell death caused by etoposide exposure in the human retinal pigment epithelial cell line, ARPE-19. The ...
Source: Biochemical Pharmacology - April 18, 2016 Category: Drugs & Pharmacology Authors: Hytti M, Tokarz P, Määttä E, Piippo N, Korhonen E, Suuronen T, Honkakoski P, Kaarniranta K, Lahtela-Kakkonen M, Kauppinen A Tags: Biochem Pharmacol Source Type: research