Filtered By:
Source: Biochemical Pharmacology
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 204 results found since Jan 2013.
Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress
This study investigated the effects of VAL on lipid accumulation and lipogenesis in human primary hepatocytes. Treatment with VAL suppressed lipid accumulation and expressions of lipogenic genes, such as processed sterol regulatory element binding proteins (SREBP1) and stearoyl-CoA desaturase-1 (SCD1) in palmitate-treated hepatocytes. Furthermore, VAL ameliorated dose-dependently palmitate-induced ER stress markers. Treatment of hepatocytes with VAL increased AMPK phosphorylation and SIRT6 expression. siRNA-mediated suppression of AMPK or SIRT6 abolished the effects of VAL on lipid accumulation, lipogenesis, and endoplasmi...
Source: Biochemical Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Authors: Seung Yeon Park Wonjun Cho A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Tae Woo Jung Source Type: research
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy
Biochem Pharmacol. 2021 Dec 27:114899. doi: 10.1016/j.bcp.2021.114899. Online ahead of print.ABSTRACTThe accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the intermediates formed during the aggregation process to be toxic to cells. Current PD treatments only provide symptomatic relief, and α-syn serves as a promising target to develop a disease-modifying therapy for PD. Our previous studies have revealed that a small-molecul...
Source: Biochemical Pharmacology - December 30, 2021 Category: Drugs & Pharmacology Authors: H Cui S Norrbacka T T My öhänen Source Type: research
Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF- α-mediated apoptosis of cancer cells
Biochem Pharmacol. 2021 Dec 2:114865. doi: 10.1016/j.bcp.2021.114865. Online ahead of print.ABSTRACTPrevious studies have confirmed that docetaxel (DTX) treatment increases TNF-α production in cancer cells, but its mechanism of action remains unclear. Therefore, this study aimed to determine the signaling axis by which DTX induced the expression of TNF-α in U937 leukemia and MCF-7 breast carcinoma cells. DTX treatment promoted Ca2+-controlled autophagy and SIDT2 expression, resulting in lysosomal degradation of miR-25 in U937 cells. Downregulation of miR-25 increased NOX4 mRNA stability and protein expression. NOX4-stimu...
Source: Biochemical Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Liang-Jun Wang Jing-Ting Chiou Yuan-Chin Lee Long-Sen Chang Source Type: research
Involvement of REV-ERB α dysregulation and ferroptosis in aristolochic acid I-induced renal injury
In conclusion, we identify REV-ERBα as a regulator of AAI-induced renal injury via promoting ferroptosis. Targeting REV-ERBα may represent a promising approach for management of AAI nephropathy.PMID:34673015 | DOI:10.1016/j.bcp.2021.114807
Source: Biochemical Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Authors: Yi Wang Zhigang Wang Zhengping Wu Menglin Chen Dong Dong Pei Yu Danyi Lu Baojian Wu Source Type: research
Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma
Biochem Pharmacol. 2021 Oct 18;193:114806. doi: 10.1016/j.bcp.2021.114806. Online ahead of print.ABSTRACTThe pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes with diagnostic and prognostic meaning and to identify potential therapeutic agents for HCC treatment. Here, CDK1, CCNB1 and CCNB2 were found to be highly expressed in HCC patients and accompanied by poor prognosis, and knockdown of them by siRNA drastically induced autophagy...
Source: Biochemical Pharmacology - October 21, 2021 Category: Drugs & Pharmacology Authors: Shuangshuang Yin Shenshen Yang Yanming Luo Jia Lu Gaoyong Hu Kailong Wang Yingying Shao Shiyue Zhou Sangho Koo Yuling Qiu Tao Wang Haiyang Yu Source Type: research
Acyl-CoA synthetase-4 mediates radioresistance of breast cancer cells by regulating FOXM1
Biochem Pharmacol. 2021 Aug 3:114718. doi: 10.1016/j.bcp.2021.114718. Online ahead of print.ABSTRACTThe development of radioresistance during radiotherapy is a major cause of tumor recurrence and metastasis. To provide new insights of the mechanisms underlying radioresistance, we established radioresistant cell lines derived from two different subtypes of breast cancer cells, HER2-positive SK-BR-3 and ER-positive MCF-7 breast cancer cells, by exposing cells to 48∼70 Gy of radiation delivered at 4-5 Gy twice weekly over 9∼10 months. The established radioresistant SK-BR-3 (SR) and MCF-7 (MR) cells were resistant not only...
Source: Biochemical Pharmacology - August 6, 2021 Category: Drugs & Pharmacology Authors: Yun-Suk Kwon Min-Gu Lee Junyoung Baek Nam-Yi Kim Hyunsoo Jang Soyoung Kim Source Type: research
HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis
Biochem Pharmacol. 2021 Jul 30:114716. doi: 10.1016/j.bcp.2021.114716. Online ahead of print.ABSTRACTA total number of 18 different isoforms of histone deacetylases (HDACs) which were categorized into 4 classes have been identified in human. HDAC3 is categorized as Class I HDACs and is closely related to the occurrence and development of atherosclerosis. Recent evidence has pointed to endothelial-to-mesenchymal transition (EndMT) as a key process in vascular inflammation in atherosclerosis. However, little is known about the effect of HDAC3 on EndMT in atherosclerosis. Therefore, we aimed to investigate the effect of HDAC3...
Source: Biochemical Pharmacology - August 2, 2021 Category: Drugs & Pharmacology Authors: Lifang Chen Chenxu Shang Bo Wang Guan Wang Zhen Jin Feng Yao Zejun Yue Liang Bai Rong Wang Sihai Zhao Enqi Liu Weirong Wang Source Type: research
