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Source: Biochemical Pharmacology

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Total 204 results found since Jan 2013.

Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer
Biochem Pharmacol. 2023 Apr 26:115564. doi: 10.1016/j.bcp.2023.115564. Online ahead of print.ABSTRACTCellular protein synthesis is accelerated in human colorectal cancer (CRC), and high expression of protein synthesis regulators in CRC patients is associated with poor prognosis. Thus, inhibition of protein synthesis may be an effective therapeutic strategy for CRC. We previously demonstrated that the quassinoid bruceantinol (BOL) had antitumor activity against CRC. Herein, potent tumor growth suppression (>80%) and STAT3 inhibition was observed in two different mouse models following BOL administration. Loss of body and...
Source: Biochemical Pharmacology - April 28, 2023 Category: Drugs & Pharmacology Authors: Ning Wei James Burnett Desirae L Crocker Yixian Huang Song Li Peter Wipf Edward Chu John C Schmitz Source Type: research

CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF- β/Smad signaling
Biochem Pharmacol. 2023 Mar 2;210:115475. doi: 10.1016/j.bcp.2023.115475. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a type of fatal respiratory diseases with limited therapeutic options and poor prognosis. The chemokine CCL17 plays crucial roles in the pathogenesis of immune diseases. Bronchoalveolar lavage fluid (BALF) CCL17 levels are significantly higher in patients with idiopathic PF (IPF) than in healthy volunteers. However, the source and function of CCL17 in PF remain unclear. Here, we demonstrated that the levels of CCL17 were increased in the lungs of IPF patients and mice with bleomycin (BLM)-induc...
Source: Biochemical Pharmacology - March 4, 2023 Category: Drugs & Pharmacology Authors: Qian-Rong Wang Suo-Si Liu Jia-Li Min Min Yin Yan Zhang Yu Zhang Xiang-Ning Tang Xia Li Shan-Shan Liu Source Type: research

SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)
CONCLUSIONS: We identified SIRT6 as a new regulator of the activity of NOS3, with functional implications for endothelial-dependent relaxation.PMID:36720357 | DOI:10.1016/j.bcp.2023.115439
Source: Biochemical Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Jiaojiao Wang Zhiping Liu Jing Lu Jiami Zou Weile Ye Hong Li Si Gao Peiqing Liu Source Type: research

Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway
In conclusion, we identified an otoprotective effect of aucubin. Therefore, aucubin could be used to prevent cisplatin-induced ototoxicity.PMID:36720354 | DOI:10.1016/j.bcp.2023.115440
Source: Biochemical Pharmacology - January 31, 2023 Category: Drugs & Pharmacology Authors: Yumeng Jiang Zhuangzhuang Li Qiang Ma Wenqi Dong Qingxiu Yao Dongzhen Yu Source Type: research

MiR-133a-3p/Sirt1 epigenetic programming mediates hypercholesterolemia susceptibility in female offspring induced by prenatal dexamethasone exposure
In conclusion, PDE can cause persistent enhancement of hepatic cholesterol synthesis function before and after birth through GR/miR-133a-3p/Sirt1 pathway, eventually leading to increased hypercholesterolemia susceptibility in female offspring rats.PMID:36326533 | DOI:10.1016/j.bcp.2022.115306
Source: Biochemical Pharmacology - November 3, 2022 Category: Drugs & Pharmacology Authors: Xufeng Li Wen Hu Li Li Ze Chen Tao Jiang Dingmei Zhang Kexin Liu Hui Wang Source Type: research

Blockage of MyD88 in cardiomyocytes alleviates cardiac inflammation and cardiomyopathy in experimental diabetic mice
In this study, we first found that MyD88 expression was increased in cardiomyocytes of diabetic mouse hearts. In cultured cardiomyocytes, MyD88 inhibition either by siRNA or by small-molecular inhibitor LM8 markedly blocked TLR4-MyD88 complex formation, reduced pro-inflammatory mitogen-activated protein kinases/nuclear factor-κB (MAPKs/NF-κB) cascade activation and decreased pro-inflammatory cytokine expression under high glucose condition. Moreover, pharmacologic inhibition of MyD88 by LM8 showed significantly anti-inflammatory, anti-hypertrophic and anti-fibrotic effects in the hearts of both type 1 and type 2 diabetic...
Source: Biochemical Pharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Wu Luo Gaojun Wu Xiaojun Chen Qiuyan Zhang Chunpeng Zou Jun Wang Jun Liu Nipon Chattipakorn Yi Wang Guang Liang Source Type: research

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