Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

In conclusion, this study describes that decrease of PXR expression levels and ligand-dependent activation of PXR and LXR increase hepatic SMPDL3A levels, which possibly connects these receptors to hepatic purinergic signaling and phospholipid metabolism and may result in drug-drug interactions with phosphoramidate pro-drugs. PMID: 28414139 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28414139?dopt=Abstract

Source: Biochemical Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O Tags: Biochem Pharmacol Source Type: research