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LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling.
In conclusion, LAZ3 protects against cardiac remodeling in DCM by decreasing miR-21, thus regulating PPARa/NRF2 signaling. PMID: 30031228 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - July 18, 2018 Category: Biochemistry Authors: Gao L, Liu Y, Guo S, Xiao L, Wu L, Wang Z, Liang C, Yao R, Zhang Y Tags: Biochim Biophys Acta Source Type: research

β-cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy.
Abstract Cardiac stem cells (CSCs) have emerged as promising cell candidates to regenerate damaged hearts, because of the potential in differentiating to cardiomyocytes. However, the differentiation is difficult to trigger without inducers. Here we reported that β-cyclodextrin (β-CD) increased the expression of cardiac transcription factors (Nkx2.5 and GATA4), structural proteins (cardiac Troponin T, cTnt), transcriptional enhancer (Mef2c) and induced GATA4 nucleus translocation in adult resident CSCs, thus β-CD could be used to enhance myogenic transition. As the differentiation process was accompanied by auto...
Source: Biochimica et Biophysica Acta - May 15, 2017 Category: Biochemistry Authors: Shi X, Li W, Liu H, Yin D, Zhao J Tags: Biochim Biophys Acta Source Type: research

Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1.
CONCLUSIONS: Our data demonstrate that AST improves cardiac function and attenuates fibrosis by decreasing phosphorylation and deacetylation of R-SMADs. SIRT1 contributes to AST's protective function by reducing acetylation of R-SMADs. GENERAL SIGNIFICANCE: These data suggest that AST may be useful as a preventive/therapeutic agent for cardiac dysfunction and myocardial fibrosis. PMID: 28300638 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - March 10, 2017 Category: Biochemistry Authors: Zhang J, Wang QZ, Zhao SH, Ji X, Qiu J, Wang J, Zhou Y, Cai Q, Zhang J, Gao HQ Tags: Biochim Biophys Acta Source Type: research

D-3-deoxy-dioctanoylphosphatidylinositol Induces Cytotoxicity in Human MCF-7 Breast Cancer Cells via a Mechanism that Involves Downregulation of the D-type Cyclin-Retinoblastoma Pathway.
Abstract Phosphatidylinositol analogs (PIAs) were originally designed to bind competitively to the Akt PH domain and prevent membrane translocation and activation. D-3-deoxy-dioctanoylphosphatidylinositol (D-3-deoxy-diC8PI), but not compounds with altered inositol stereochemistry (e.g., L-3-deoxy-diC8PI and L-3,5-dideoxy-diC8PI), is cytotoxic. However, high resolution NMR field cycling relaxometry shows that both cytotoxic and non-toxic PIAs bind to the Akt1 PH domain at the site occupied by the cytotoxic alkylphospholipid perifosine. This suggests another mechanism for cytotoxicity must account for the difference...
Source: Biochimica et Biophysica Acta - September 2, 2016 Category: Biochemistry Authors: Gradziel CS, Jordan PA, Jewel D, Dufort FJ, Miller SJ, Chiles TC, Roberts MF Tags: Biochim Biophys Acta Source Type: research

Receptor for hyaluronic acid- mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a β-catenin/c-myc signaling axis.
CONCLUSIONS: LMWHA/RHAMM downstream signaling regulates fibrosarcoma cell growth in a β-catenin/c-myc dependent manner. GENERAL SIGNIFICANCE: The present study suggests that RHAMM is a novel β-catenin intracellular binding partner, protecting β-catenin from degradation and supporting the nuclear translocation of this key cellular mediator, which results in c-myc activation and enhanced fibrosarcoma cell growth. PMID: 26825774 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 26, 2016 Category: Biochemistry Authors: Kouvidi K, Berdiaki A, Tzardi M, Karousou E, Passi A, Nikitovic D, Tzanakakis GN Tags: Biochim Biophys Acta Source Type: research

Regulation of Chondroitin-4-Sulfotransferase (CHST11) Expression by Opposing Effects of Arylsulfatase B on BMP4 and Wnt9A.
In this report, the gene regulatory mechanism by which decline in arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) reduces CHST11 (chondroitin-4-sulfotransferase; C4ST) mRNA expression in human colonic epithelial cells and in colonic epithelium of ARSB-deficient mice is presented. ARSB controls the degradation of chondroitin 4-sulfate (C4S) by removing the 4-sulfate group at the non-reducing end of the C4S chain, but has not previously been shown to affect C4S biosynthesis. The decline in CHST11 expression following ARSB reduction is attributable to effects of ARSB on bone morphogenetic protein (BMP)4, since BMP4 ...
Source: Biochimica et Biophysica Acta - December 12, 2014 Category: Biochemistry Authors: Bhattacharyya S, Feferman L, Tobacman JK Tags: Biochim Biophys Acta Source Type: research

Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells.
Abstract Anti-apoptotic Bcl-2 family proteins have been reported to play an important role in apoptotic cell death of human malignancies. The aim of this study was to delineate the mechanism of anti-apoptotic Bcl-2 family proteins in pancreatic cancer (PaCa) cell survival. We first analyzed the endogenous expression and subcellular localization of anti-apoptotic Bcl-2 family proteins in six PaCa cell lines by Western blot. To delineate the functional role of Bcl-2 family proteins, siRNA-mediated knock-down of protein expression was used. Apoptosis was measured by Cell Death ELISA and Hoechst 33258 staining. In the...
Source: Biochimica et Biophysica Acta - August 14, 2013 Category: Biochemistry Authors: Takahashi H, Chen MC, Pham H, Matsuo Y, Ishiguro H, Reber HA, Takeyama H, Hines OJ, Eibl G Tags: Biochim Biophys Acta Source Type: research