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Epac1 participates in β < sub > 1 < /sub > -adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes
This study confirmed that Epac1 upregulation is indeed involved β1-AA-induced decreased cardiomyocyte autophagy through CE3F4 pretreatment, Epac1 siRNA transfection, western blot and immunofluorescence methods. On this basis, we constructed β1-AR and β2-AR knockout mice, and used receptor knockout mice, β1-AR selective blocker (atenolol), and the β2-AR/Gi-biased agonist ICI 118551 to show that β1-AA upregulated Epac1 expression through β1-AR and β2-AR to inhibit autophagy, and biased activation of β2-AR/Gi signaling downregulated myocardial Epac1 expression to reverse β1-AA-induced myocardial autophagy inhibition...
Source: Biochimica et Biophysica Acta - June 14, 2023 Category: Biochemistry Authors: Yang Li Yuan Tian Shu Shi Xiaohong Hou Haihu Hao Mingxia Ma Na Ning Yuan Yuan Xiaohui Wang Huirong Liu Li Wang Source Type: research

LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling.
In conclusion, LAZ3 protects against cardiac remodeling in DCM by decreasing miR-21, thus regulating PPARa/NRF2 signaling. PMID: 30031228 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - July 18, 2018 Category: Biochemistry Authors: Gao L, Liu Y, Guo S, Xiao L, Wu L, Wang Z, Liang C, Yao R, Zhang Y Tags: Biochim Biophys Acta Source Type: research

The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1.
Abstract The TIR/BB-loop mimetic AS-1 has been reported to prevent cardiac hypertrophy by inhibiting interleukin-1 receptor (IL-1R)-mediated myeloid differentiation primary response gene 88 (MyD88)-dependent signaling. To date, it remains unknown whether and if so how AS-1 contributes to mechanical stress (MS)-induced cardiac fibroblast activation, a key process in pressure overload-induced cardiac remodeling and heart failure. Here, we show that phosphorylation and expression of large tumor suppressor kinase 1 (LATS1), a key molecule in the Hippo-Yes associated protein (YAP) signaling pathway, were down-regulated...
Source: Biochimica et Biophysica Acta - March 7, 2016 Category: Biochemistry Authors: Fan M, Song J, He Y, Shen X, Li J, Que L, Zhu G, Zhu Q, Cai X, Ha T, Chen Q, Xu Y, Li C, Li Y Tags: Biochim Biophys Acta Source Type: research