Filtered By:
Source: Cancer Research
This page shows you your search results in order of date. This is page number 15.
Order by Relevance | Date
Total 807 results found since Jan 2013.
Abstract 1956: A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions
In conclusion, our findings suggest that the Hippo-YAP1-AR signaling axis is one of the key mechanisms for metastatic PC progression and may represent as a promising therapeutic target for patients with the lethal disease.Note: This abstract was not presented at the meeting.Citation Format: Bekir Cinar, Gamze Kuser Abali, Michael Lewis, Colm Morrissey, Isla Garraway. A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia,...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Cinar, B., Kuser Abali, G., Lewis, M., Morrissey, C., Garraway, I. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1964: Role of AMP kinase in TRAIL and PPAR{gamma} ligand combination-induced apoptosis and {beta}-catenin cleavage
In this study we found that TRAIL-TZD-induced β-catenin cleavage also involves AMPK. Knockdown of AMPKα showed strong reduction of the cleaved β-catenin product in both cell types. Since TZD is an agonist of PPARγ, we also determined its involvement in this apoptosis pathway. Endogenous expression of PPARγ showed significant differences between DU145 and LNCaP cells, with higher level expression in the DU145 cells. Knockdown of PPARγ in DU145 cells showed a reduction of cleaved caspase 3 levels whereas cleaved caspase 8, 9 and PARP levels were largely unaffected. Luciferase assays with PPARγ-responsive reporter (PPR...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Santha, S., Basu, A., Rana, A., Rana, B. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1966: Role of Wnt-Beta-Catenin signals in the control of vascular mimicry in TNBC
Background: TNBC or basal-like subtype of breast cancer confers poor clinical outcome mostly due to its inherent aggressive nature and its high frequency of metastasis. Malignancy in TNBC is associatedwith micro-vascular proliferations. Vascular Mimicry (VM) of solid tumor is an endothelium-independent matrix-embedded, blood-perfused non-angiogenic micro-circulatory phenomenon. VM of tumor cells refer to the characteristic plasticity of aggressive cancer cells forming de novo vascular networks which perfuse rapidly growing tumors, transporting fluid from leaky vessels and/or connect with the constitutional endothelial-line...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Leyland-Jones, B., Carlson, J. H., De, P., Dey, N. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1967: Elucidation of signaling pathways that mediate gastrin-induced JNK activation and pGSK3{beta}/Snail induction in gastric cancer cells
The gastrointestinal peptide hormone gastrin is known to regulate various cellular processes including proliferation, migration and metastasis in gastrointestinal cells. Our previous studies indicated that amidated gastrin (G-17) induced gastric cancer cell migration through two separate signaling axes. These revealed that inhibition of Glycogen Synthase Kinase-3β (GSK3β) was necessary to activate G17-induced migratory pathways in gastric cancer cells. Incubation of AGSE gastric cancer cells overexpressing CCK2 receptor (CCK2R) with G17 resulted in a dose and time dependent increase of GSK3βSer9 phosphorylation, indicat...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Basu, A., Sondarva, G., Santha, S., Rana, A., Rana, B. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1972: LIN28 gene targets are key mediators of breast cancer disease processes
LIN28 is an evolutionally conserved RNA-binding protein with critical functions in developmental timing, pluripotency and reprogramming. At the molecular level, most studies indicate that LIN28 modulates gene networks and biological processes by negatively regulating miRNA biogenesis and post-transcriptionally regulating mRNA translation. In addition, increasing evidence suggests that LIN28 is an oncogene, promoting cell growth in various cancers, including breast cancer; however the molecular mechanisms underlying these effects are not known. To provide mechanistic insights into how LIN28 modulates the gene networks that ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kinyamu, H. K., Yang, J., Bennett, B., Grimm, S., Bushel, P., Archer, T. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1980: Identification of the transcription factor ZNF217 in ER+ subset of BC: A functional relationship with the PI3K-AKT-mTOR pathway
ZNF217 gene encodes for a Krüppel-like finger protein transcription factor. Here we report an amplification of ZNF217 gene in breast cancer (BC) patients. Retrospective study of 72 BC patients showed that ZNF217 gene was amplified in 12.5% of patients enrolled in our center over last ten months from February 2014 through November 2014. We found a similar level of amplification of ZNF217 gene at 20q13 in different epithelial cancers including lung, uterus, ovary, stomach, bladder and breast using data from c-Bioportal. The observed percentage of the amplification of ZNF217 gene in our patients (12.5%) was comparable to the...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dey, N., Williams, C., Krie, A., Solomon, B., Starks, D., Rojas, L., Carlson, J. H., Sun, Y., Lin, X., Abramovitz, M., Metzger-Nelson, T., Williams, K., Klein, J., De, P., Leyland-Jones, B. Tags: Molecular and Cellular Biology Source Type: research
Abstract 1992: Evidence for modulation of FoxM1 by p21 in ovarian cancer
The oncogenic transcription factor forkhead box M1 (FoxM1) is overexpressed in many cancers, including 84% of ovarian cancer and plays a role in DNA repair, mitotic checkpoint, cell proliferation, and cancer drug resistance. Similar to Her2 in breast cancer, the constitutive expression of FoxM1 makes it a plausible gene target for novel anti-cancer therapies, but the regulation of FoxM1 has yet to be elucidated. Evidence suggests FoxM1 up-regulation is a result of TP53 mutations, however, no TP53 response element has been found within the FoxM1 promoter, thus there is likely another molecule mediating p53-induced FoxM1 ove...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Madden, J., Chien, J. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2006: Kinases and adaptive signaling contribute to drug resistance in BRAF mutant melanoma
Melanoma, the most lethal form of skin cancer, is marked by numerous genetic modifications, including point mutations as well as overexpression and deletion of genes. Intrinsic and acquired resistance to BRAF V600E targeted therapies (BRAFi) in metastatic melanoma patients further underscores the need for global profiling of melanoma circuitry at the functional level. Therefore, activity-based protein profiling (ABPP) and phosphoproteomics was carried out to decipher steady state differences in global signaling mechanisms in naïve and BRAFi resistant melanoma cell lines with BRAF V600E mutations.Four cell lines (A375, 120...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Sharma, R., Phadke, M., Britton, D., Pike, I., Smalley, K., Koomen, J. M. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2030: FRK regulates glioma cell progression by promoting N-cadherin/{beta}-catenin complex formation
In this study, we found that FRK over-expression increased the protein level of N-cadherin, but not that of E-cadherin. Meanwhile, FRK over-expression promoted β-catenin translocation to the plasma membrane, where it formed complex with N-cadherin, while inhibited β-catenin translocation to the nucleus. In addition, down-regulation of N-cadherin by siRNA promoted the migration/ invasion proliferation and inhibited apoptosis of glioma U251 and U87 cells. Interestingly, N-cadherin down-regulation abolished the effect of FRK on glioma cell migration/invasion, proliferation and apoptosis. In summary, these results indicate t...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Shi, Q., Song, X., Yan, H., Wang, J., Zhang, W., Hu, J., Zhou, X., Yu, R. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2043: SATB1 (special AT-rich binding protein 1) as a putative therapeutic target in colorectal cancer
In this study, we have analyzed the function of SATB1 in primary and in established colorectal cancer cell lines and determined the therapeutic relevance of SATB1-specific gene knockdown approaches by RNA interference (RNAi). In CRC cells, an RNAi-mediated knockdown of the SATB1 was achieved by transient or by stable transfection with specific siRNAs or shRNAs-encoding plasmids, each leading to markedly reduced SATB1 mRNA and protein levels. SATB1 knockdown caused an inhibition of proliferation, a deceleration of cell cycle progression and pro-apoptotic effects. Further analyses revealed effects of SATB1 on multiple signal...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Fromberg, A., Rabe, M., Linnebacher, M., Aigner, A. M. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2045: Sleeping Beauty mutagenesis screening identifies a novel tumor suppressor gene involved in liver tumor development
Conclusion: RNF125 gene is a novel tumor suppressor gene for human HCC and plays an important role in cellular proliferation. RNF125 gene is frequently inactivated in human HCC and therefore its functional recovery could be a potential therapeutic target of HCC.Citation Format: Takahiro Kodama, Zhubo Wei, Michiko Kodama, Nancy Jenkins, Neal Copeland. Sleeping Beauty mutagenesis screening identifies a novel tumor suppressor gene involved in liver tumor development. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AAC...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kodama, T., Wei, Z., Kodama, M., Jenkins, N., Copeland, N. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2047: CDK10 promotes tumour growth and chemoresistance in colorectal cancer, and is a potential target for treatment
In this study, we were interested in examining the role of CDK10 in growth, apoptosis, chemoresistance, and as a therapeutic target in CRC.CRC cell lines stably overexpressing CDK10 wild type (WT) as well as a kinase defective/dominant negative (DN) form of CDK10 were established in CRC cell lines RKO, HCT-15 and MIP101. Knockdown of CDK10 was achieved via siRNA. MTS and colony-forming assays were used to examine the response to 5-Fluorouracil (5-FU); TUNEL, caspase 3/7 assays, for apoptosis; and signaling events by immunoblotting. Cell growth in vivo was monitored after injection of cell lines into the flanks of Nude mice...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Weiswald, L.-B., Hasan, M. R., Rahman, M., Pasiliao, C., Tai, I. T. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2049: Characterization of a novel BRCA1-EGR1 interaction
The tumor suppressor protein BRCA1 orchestrates DNA repair and cell cycle arrest following DNA damage, with transcriptional regulation integral to these processes. We have identified a novel, DNA-damage responsive, interaction between BRCA1 and the zinc-finger transcription factor EGR1. EGR1 is rapidly and transiently expressed in response to a wide variety of stress stimuli and growth factors, and like BRCA1, decreased expression of EGR1 correlates with tumor formation in mammary cell lines and tissues.The stress response gene, NDRG1, was identified as a transcriptional target of BRCA1 by microarray analysis and subsequen...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dickson, N. A., Crawford, N. T., Mullan, P. B. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2054: In pancreatic cancer, MUC1 regulates function of TGF-{beta} and thus enhances metastasis
ConclusionMUC1 expression is directly correlated with TGF-β function and expression of TGF-βRII, while being negatively correlated with TGF-βRI expression. This has high clinical significance for patients with PDA.Citation Format: Priyanka Grover, Sritama Nath, Mohammad Ahmad, Pinku Mukherjee. In pancreatic cancer, MUC1 regulates function of TGF-β and thus enhances metastasis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2054. doi:10.1158/1538-7445.AM2015-2054
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Grover, P., Nath, S., Ahmad, M., Mukherjee, P. Tags: Molecular and Cellular Biology Source Type: research
Abstract 2081: The CCCTC-binding factor (CTCF) functions to downregulate the transcription of MGMT gene in human glioblastoma cells
The O6-methylguanine-DNA methyltransferase (MGMT) gene located at chromosome 10q26 encodes a DNA repair protein that abrogates the therapeutic effects of alkylating agents by preventing the formation of mutagenic lesions or cytotoxic DNA crosslinks. MGMT is highly expressed in human gliomas and its transcriptional regulation has emerged as a major translational focal point in neuro-oncology, because the epigenetic silencing of the MGMT gene which occurs in a subset of these malignancies confers improved treatment responses to both chemo and radiation therapies. While the promoter methylation and its contribution to glioma ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Srivenugopal, K. S., Al-Obaide, M. I. Tags: Molecular and Cellular Biology Source Type: research
