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Source: Cancer Research
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Total 807 results found since Jan 2013.
Abstract 29: Potent curcumin analog FLLL12 induces apoptosis in lung cancer cells through death receptor-5-dependent pathway
Conclusions: Our results strongly suggest that FLLL12 induces apoptosis of lung cancer cell lines by posttranscriptional regulation of DR5 through activation of protein tyrosine phosphatase(s). This study was supported by NCI R03 CA171663, NCI P50 CA128613 and Robbins Scholar Award of Winship Cancer Institute of Emory University.Citation Format: Abedul Haque, Mohammad A. Rahman, James R. Fuchs, Zhuo G. Chen, Fadlo R. Khuri, Dong M. Shin, A.R.M. Ruhul Amin. Potent curcumin analog FLLL12 induces apoptosis in lung cancer cells through death receptor-5-dependent pathway. [abstract]. In: Proceedings of the 106th Annual Meeting ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Haque, A., Rahman, M. A., Fuchs, J. R., Chen, Z. G., Khuri, F. R., Shin, D. M., Amin, A. R. M. R. Tags: Molecular and Cellular Biology Source Type: research
Abstract 35: Diacylglycerol kinase zeta-mediated regulation of mTOR and SREBP-1 offers new opportunities for cancer management
Diacylglycerol (DAG) and phosphatidic acid (PA) are two lipids that lie at the core of several metabolic and signaling pathways, which allows integrated control of cell growth and nutrient sensing with cell metabolism. Diacylglycerol kinases (DGK) are a family of enzymes that balance the levels of both lipids. Some DGK isoforms, mainly DGKα, have been recently suggested as potential targets for cancer treatment (Dominguez et al, 2013; Torres-Ayuso et al, 2014). Previous observations from us indicate that the DGKζ isoform contributes the most to DGK activity in cancer cells, and DGKζ-derived PA is required for mTOR activ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Torres-Ayuso, P., Jones, D., Tello-Lafoz, M., Avila-Flores, A., Merida, I. Tags: Molecular and Cellular Biology Source Type: research
Abstract 37: Role and regulation of CYP24A1 in endometrial cancer
The cytochrome P450 enzyme, 24-hydroxylase, encoded by CYP24A1 is critical for the catabolism of 1,25(OH)2D3 (calcitriol). The unbalanced high levels of CYP24A1 seem to be a determinant of calcitriol resistance in tumors. We have previously shown that progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. In the present study, we evaluated CYP24A1 protein expression in normal and endometrial tumor tissues, assessed the effect of progesterone and calcitriol on CYP24A1 and its spliced variant expression in endometrial cancer cell ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Bokhari, A. A., Lee, L. R., Dewayne, R., Hamilton, C. A., Maxwell, G. L., Rodriguez, G. C., Syed, V. Tags: Molecular and Cellular Biology Source Type: research
Abstract LB-043: Highly specific and sensitive nanoimmunoassay of PARP1 as cell death measurement toolkit
In this study we developed highly sensitive and specific antibodies against PARP1 fragments. Using siRNAs against 18 PARP family members, we validated antibody specificity by western blotting and nanoimmunoassay (NIA). NIA is a highly sensitive platform capable of screening up to 96 cancer samples at sub-microliter volume. Moreover, this platform permits quantitative analysis of non-modified PARP1 as well as post-translational modifications such as PARylation and phosphorylation using a single antibody for the measurement of all species. We anticipate this workflow will be amenable to a wide range of protein targets, usher...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Pontikos, M. A., Zimmermann, A., Moncada, C., Abarca Heidemann, K. V., Miller, J. B., Birabaharan, J., Boyer, M., Zuck, R. M., Lorenzi, P. L., Ascoli, C. Tags: Molecular and Cellular Biology Source Type: research
Abstract 44: EGFR and Dock180 activate MLK3 to drive invasion of glioblastoma cells
Glioblastoma (GBM) is the most common and deadly form of brain tumor in adults, with an average post-diagnosis survival time of 15 months. While GBMs rarely metastasize to distant organs, they readily invade into surrounding brain tissue, leading to incomplete surgical resection and subsequent tumor recurrence. Epidermal Growth Factor Receptor (EGFR) signaling is aberrantly activated in a majority of GBM tumors, and is clearly implicated in multiple malignant phenotypes, including migration and invasion. However, direct targeting of EGFR has been largely unsuccessful, for multiple reasons, including compensatory upregulati...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Misek, S. A., Chen, J., Gallo, K. A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 53: Interplay among E3 ubiquitin ligases regulate timely degradation of the circadian factor Period 2
Circadian rhythms are mechanisms that measure time on a scale of about 24 h and that adjusts our body to external environmental signals. Core circadian clock genes are defined as genes whose protein products are necessary components for the generation and regulation of circadian rhythms.Oscillatory rhythms are generated as result of the activation of positive and negative transcriptional feedback loops in which post-translational modifications, shuttling, and degradation are common themes. In mammals, the positive feedback loop involves regulation of bmal1 transcription. BMAL1/CLOCK selectively binds to E-box enhancers and...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Finkielstein, C. V., liu, j. Tags: Molecular and Cellular Biology Source Type: research
Abstract 54: Ezrin enhances signaling and nuclear translocation of the epidermal growth factor receptor in non-small cell lung cancer cells
The cytoskeletal cross linker protein ezrin is a member of the ezrin-radixin-moesin (ERM) family and plays important roles not only in cell motility, cell adhesion, and apoptosis, but also in various cell-signaling pathways. Ezrin interacts with EGFR in the cell membrane and involves in cell motility events, but little is known about the effects of this interaction on the EGFR signaling pathway. We investigated the role of Ezrin in EGFR signaling and nuclear trafficking in non-small cell lung cancer (NSCLC) cell lines. The ligand induced interaction between Ezrin and EGFR was evaluated by immunoprecipitation (IP) and immun...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Saygideger Kont, Y., Celik, H., Erkizan, H. V., Minas, T., Han, J., Toretsky, J., Uren, A. Tags: Molecular and Cellular Biology Source Type: research
Abstract 66: CD99 functional analysis in glioblastoma by RNAseq
CD99 is a membrane protein expressed in a wide variety of normal tissues and implicated in several cellular physiologic processes, including haematopoietic cell differentiation, proliferation, diapedesis, cell-cell adhesion, migration, apoptosis induction, cellular architecture maintenance and transmembrane protein transport. Additionally, aberrant CD99 expression has been associated with numerous malignancies, including astrocytomas. Amongst astrocytomas of different malignant grades, glioblastoma (GBM) is the most aggressive and common of central nervous system tumors. Despite current multimodal therapies, including surg...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Oba-Shinjo, S. M., Cardoso, L. C., Silva, R. d., Lerario, A. M., Uno, M., Marie, S. S. K. Tags: Molecular and Cellular Biology Source Type: research
Abstract 101: WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck
Conclusions: WHSC1L1 is genetically altered in multiple cancer types. In SCCHN, it is significantly overexpressed in 24% of the tumors and its knockdown caused significant growth suppression of both HPV-positive and HPV-negative SCCHN cell lines. Taken together, WHSC1L1 merits further investigation as a potential therapeutic target in SCCHN.Citation Format: Vassiliki Saloura, Theodore Vougiouklakis, Mark Lingen, Tanguy Seiwert, Everett Vokes, Yusuke Nakamura, Ryuji Hamamoto. WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck. [abstract]. In: Proceedings of the 106th Annual Meeting of the Americ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Saloura, V., Vougiouklakis, T., Lingen, M., Seiwert, T., Vokes, E., Nakamura, Y., Hamamoto, R. Tags: Molecular and Cellular Biology Source Type: research
Abstract LB-102: Layer-by-layer engineering of upconversion nanoparticle based siRNA and miRNA delivery system for cancer therapy
Conclusions: In this proof-of-concept study, a layer-by-layer engineered UCNP based siRNA and miRNA delivery system was successfully developed. Our novel delivery system opens up preparation of advanced UCNP based photoresponsive delivery systems that allow remote, precise, and trackable control over therapeutic payload (e.g., drug, gene) release for better cancer theranostics.Citation Format: Lin Min, YAN GAO, Francis J. Hornicek, Mansoor M. Amiji, Zhenfeng Duan. Layer-by-layer engineering of upconversion nanoparticle based siRNA and miRNA delivery system for cancer therapy. [abstract]. In: Proceedings of the 106th Annual...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Min, L., GAO, Y., Hornicek, F. J., Amiji, M. M., Duan, Z. Tags: Cancer Chemistry Source Type: research
Abstract 16: Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necroptosis in C4-2B osseous metastatic castration-resistant prostate cancer cells
Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis in part due to enhanced aerobic glycolysis and biomass production, known as Warburg effect. We previously demonstrated that combination simvastatin (SIM) and metformin (MET) ameliorates critical Warburg effect-related metabolic aberrations of C4-2B cells, synergistically and significantly decreases CRPC cell viability and metastatic properties, with minimal effect on normal prostate epithelial cells, and inhibits primary prostate tumor growth, metastasis, and biochemical failure in an orthotopic model of metastatic CRPC, more...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Babcook, M. A., Sramkoski, R. M., Fujioka, H., Daneshgari, F., Almasan, A., Shukla, S., Gupta, S. Tags: Molecular and Cellular Biology Source Type: research
Abstract 20: Honokiol radiosensitizes squamous cells carcinoma of head and neck by down-regulation of survivin
Conclusions: Survivin is a negative prognostic factor in SCCHN, and is involved in DNA damage response and repair induced by IR in SCCHN cells. Down regulation of survivin by honokiol enhances the efficacy of IR, and may provide a novel therapeutic approach to improve the efficacy of radiotherapy in SCCHN. (This research was supported by the National Cancer Institute award P50 CA128613, and GCC Distinguished Cancer Scholar to Dong M. Shin, Zhuo (Georgia) Chen, and Jonathan J Beitler)Citation Format: Xu Wang, Jonathan J. Beitler, Wen Huang, Guoqing Qian, Kelly Magliocca, Jun Zhang, Sreenivas Nannapaneni, Sungjin Kim, Zhengj...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Wang, X., Beitler, J. J., Huang, W., Qian, G., Magliocca, K., Zhang, J., Nannapaneni, S., Kim, S., Chen, Z., Nabil, S. F., Chen, Z. G., Arbiser, J. L., Shin, D. M. Tags: Molecular and Cellular Biology Source Type: research
Abstract 24: The phosphorylation of p53 at serine 46 is essential to induce cell death through palmdelphin in response to DNA damage
Tumor suppressor p53 plays a pivotal role in cell cycle arrest, DNA repair, and apoptosis in response to DNA damage. Promoter selectivity of p53 depends mainly on post-translational modification. Notably, the apoptotic function of p53 is related to its phosphorylation at serine-46 (ser46) to promote pro-apoptotic genes. However, little is known about the pro-apoptotic genes induced by Ser46 phosphorylation. Our research achieved to investigate the pro-apoptotic genes induced by p53 in a phospho-ser46-specific manner using microarray and ChIP sequencing in human cancer cell lines. As a result, palmdelphin (PALMD), an isofor...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dashzeveg, N. K., Yoshida, K. Tags: Molecular and Cellular Biology Source Type: research
Abstract LB-024: Inhibition of bone morphogenetic protein (BMP) type I receptors in lung cancer cells activates the TGF{beta} signaling cascades which increases Id1 expression by TAK1
This study reveals that TGFβ signaling can increase the expression of Id1 when BMP signaling is inhibited in lung cancer cells, which is mediated by TAK1. The data suggests that the inhibition of both the BMP and TGF signaling pathways enhances growth suppression of lung cancer cells that involves the downregulation of Id1.Citation Format: John E. Langenfeld, Elaine Langenfeld, Monica Castle. Inhibition of bone morphogenetic protein (BMP) type I receptors in lung cancer cells activates the TGFβ signaling cascades which increases Id1 expression by TAK1. [abstract]. In: Proceedings of the 106th Annual Meeting of the Americ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Langenfeld, J. E., Langenfeld, E., Castle, M. Tags: Molecular and Cellular Biology Source Type: research
Abstract 26: Suppression of E-cadherin mediates gallotannin-induced apoptosis in Hep G2 hepatocelluar carcinoma cells
Though gallotannin was known to have anti-oxidant and antitumor activity, the underlying antitumor mechanism of gallotannin still remains unclear. Thus, in the present study, antitumor mechanism of gallotannin was elucidated in hepatocellular carcinoma cells. Gallotannin significantly exerted cytotoxicity against Hep G2 and Chang hepatocellular carcinoma cells with the accumulation of the sub-G1 population and increase of terminal deoxynucleotidyltransferasedUTP nick end labeling (TUNEL) positive cells as an apoptotic feature. Also, gallotannin attenuated the expression of pro-caspase9, pro-caspase3, Bcl2 and integrin β1 ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kwon, H. Y., Jung, J. H., Lee, H. J., Jeong, M. S., Jung, D.-B., Kim, B., Lee, H., Kim, S.-H. Tags: Molecular and Cellular Biology Source Type: research
