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Source: Arthritis and Rheumatism

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Total 53 results found since Jan 2013.

PGC‐1α and FOXO3a mediate chondroprotection by AMP‐activated Protein Kinase
Conclusions: PGC‐1α and FOXO3a limit oxidative stress and at least partially mediate the capacity of AMPK activity to block pro‐catabolic responses in chondrocytes, therefore have the potential to inhibit progression of cartilage damage in OA. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - July 21, 2014 Category: Rheumatology Authors: Xianling Zhao, Freyr Petursson, Benoit Viollet, Martin Lotz, Robert Terkeltaub, Ru Liu‐Bryan Tags: Full Length Source Type: research

Inhibition of Spermidine/Spermine N1‐Acetyltransferase Activity: A New Therapeutic Concept in Rheumatoid Arthritis
ConclusionThe use of DA alone or in combination with SAM/l‐methionine might introduce a new therapeutic concept in RA. This is the first therapy that would directly target RASFs and thereby inhibit ongoing joint destruction.
Source: Arthritis and Rheumatism - June 27, 2014 Category: Rheumatology Authors: Michel Neidhart, Emmanuel Karouzakis, Astrid Jüngel, Renate E. Gay, Steffen Gay Tags: Rheumatoid Arthritis Source Type: research

Macrophage migration inhibitory factor down‐regulates the RANKL‐RANK signaling pathway by activating Lyn tyrosine kinase
Conclusions: Our findings indicate that the tyrosine kinase, Lyn, is activated when MIF binds to its receptor, CD74 and co‐receptor, CD44 and, in turn, down regulates the RANKL‐mediated signaling cascade by suppressing NFATc1 protein expression through downregulation of AP‐1 and calcium signaling components. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - May 28, 2014 Category: Rheumatology Authors: Se Hwan Mun, Dongmyung Oh, Sun‐Kyeong Lee Tags: Full Length Source Type: research

Cyclin‐Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines
ConclusionCDK‐9 activity is required for the primary inflammatory response in chondrocytes. Flavopiridol suppresses the induction of inflammatory mediator genes and catabolic genes to protect cartilage from the deleterious effects of proinflammatory cytokines, without affecting cell viability and functions.
Source: Arthritis and Rheumatism - May 27, 2014 Category: Rheumatology Authors: Jasper H. N. Yik, Zi'ang Hu, Ratna Kumari, Blaine A. Christiansen, Dominik R. Haudenschild Tags: Chondrocyte Biology Source Type: research

CD44 and Hyaluronan Promote the Bone Morphogenetic Protein 7 Signaling Response in Murine Chondrocytes
ConclusionTaken together, these investigations into the mechanisms underlying BMP‐7 signaling in chondrocytes revealed that while hyaluronan‐dependent pericellular matrix is critical for BMP‐7 signaling, the expression of CD44 promotes the cellular response to lower concentrations of BMP‐7.
Source: Arthritis and Rheumatism - May 27, 2014 Category: Rheumatology Authors: Na Luo, Warren Knudson, Emily B. Askew, Roberta Veluci, Cheryl B. Knudson Tags: Chondrocyte Biology Source Type: research

Inhibition of spermidine/spermine N1‐acetyltransferase (SSAT1) activity – a new therapeutical concept in rheumatoid arthritis
Conclusion. The use of DA alone or in combination with SAM / L‐methionine might introduce a new therapeutic concept in RA. This is the first therapy that would directly target RASF and thereby inhibit the ongoing joint destruction. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 27, 2014 Category: Rheumatology Authors: Michel Neidhart, Emmanuel Karouzakis, Astrid Jüngel, Renate E. Gay, Steffen Gay Tags: Full Length Source Type: research

Stress inducible gene nuclear protein‐1 (NUPR1/p8) regulates MMP‐13 expression in human articular chondrocytes
Conclusions: Nupr1 is expressed in cartilage, and its levels are increased in OA. Nupr1 expression is required for IL‐1β‐mediated expression of MMP‐13. Thus, our study suggests a novel pathway for regulation of IL‐1β‐mediated production of MMPs in chondrocytes. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 4, 2014 Category: Rheumatology Authors: Raghunatha R. Yammani, Richard F. Loeser Tags: Brief Report Source Type: research

CD44 and hyaluronan promote the BMP7 signaling response in chondrocytes
Conclusion: Taken together, these investigations into the mechanisms underlying BMP7 signaling in chondrocytes reveal that while hyaluronan‐dependent pericellular matrix is critical for BMP7 signaling, expression of CD44 promotes the cellular response to lower concentrations of BMP7. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 4, 2014 Category: Rheumatology Authors: Na Luo, Warren Knudson, Emily B. Askew, Roberta Veluci, Cheryl B. Knudson Tags: Full Length Source Type: research

Cyclin‐Dependent Kinase 9 inhibition protects cartilage from the catabolic effects of pro‐inflammatory cytokines
Conclusion. CDK9 activity is required for the primary inflammatory response in chondrocytes. Flavopiridol suppresses the induction of inflammatory mediators and catabolic genes to protect cartilage from the deleterious effects of pro‐inflammatory cytokines, without impacting cell viability and functions. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - January 27, 2014 Category: Rheumatology Authors: Jasper H. N. Yik, Zi'ang Hu, Ratna Kumari, Blaine A. Christiansen, Dominik R. Haudenschild Tags: Full Length Source Type: research

Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis
CONCLUSION Results indicate that lncRNA‐CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA. We propose that lncRNA‐CIR could be utilized as a potential target in OA therapy. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - December 10, 2013 Category: Rheumatology Authors: Qiang Liu, Xin Zhang, Linghui Dai, Xiaoqing Hu, Jingxian Zhu, La Li, Chunyan Zhou, Yingfang Ao Tags: Full Length Source Type: research

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
ConclusionActivation of the P2X7 signaling pathway accelerates murine LN by activating the NLRP3/ASC/caspase 1 inflammasome, resulting in increased IL‐1β production and enhanced Th17 cell polarization. Thus, targeting of the P2X7/NLRP3 pathway should be considered as a novel therapeutic strategy in patients with lupus.
Source: Arthritis and Rheumatism - November 27, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

Role of ADAM‐17, p38 MAPK, Cathepsins, and the Proteasome Pathway in the Synthesis and Shedding of Fractalkine/CX3CL1 in Rheumatoid Arthritis
ConclusionOur results provide new understanding of the role of ADAM‐17, p38 MAPK, cathepsins, and the proteasome pathway in FKN expression and shedding. Regulating these pathways may suppress FKN‐mediated inflammation and tissue destruction.
Source: Arthritis and Rheumatism - October 28, 2013 Category: Rheumatology Authors: Brian A. Jones, Sharayah Riegsecker, Ayesha Rahman, Maria Beamer, Wissam Aboualaiwi, Sadik A. Khuder, Salahuddin Ahmed Tags: Rheumatoid Arthritis Source Type: research

Combination of tumor necrosis factor a and interleukin 6 induces osteoclast‐like cells with bone‐resorption activity both invitro and invivo
Conclusion. Our results demonstrate that a combination of the inflammatory cytokines, TNFα and IL‐6, can induce osteoclast‐like cells that have in vitro and in vivo bone‐resorptive activity. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - October 7, 2013 Category: Rheumatology Authors: Kazuhiro Yokota, Kojiro Sato, Takashi Miyazaki, Hideki Kitaura, Hisako Kayama, Fumihiko Miyoshi, Yasuto Araki, Yuji Akiyama, Kiyoshi Takeda, Toshihide Mimura Tags: Full Length Source Type: research

P2X7 blockade attenuates lupus nephritis by inhibiting NLRP3/ASC/caspase‐1 activation
Conclusion. Activation of the P2X7 signaling pathway accelerates murine LN by activating NLRP3/ASC/caspase‐1 inflammasome, resulting in increased IL‐1β and enhanced Th17 cell polarization. Thus, targeting the P2X7/NLRP3 pathway as a therapeutic strategy for lupus patients should be considered. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 10, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Full Length Source Type: research

Dual role of autophagy in stress‐induced cell death in rheumatoid arthritis synovial fibroblasts
ConclusionOur data provides the first evidence of a dual role of autophagy in the regulation of death pathways in RASF. A reduced expression of ALFY and the formation of p62‐positive poly‐ubiquitinated protein aggregates promote cell death in RASF under severe ER stress. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - September 1, 2013 Category: Rheumatology Authors: Masaru Kato, Caroline Ospelt, Renate E Gay, Steffen Gay, Kerstin Klein Tags: Full Length Source Type: research