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Source: Arthritis and Rheumatism

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Total 53 results found since Jan 2013.

Proteasomal function is impaired in human osteoarthritic chondrocytes and this can contribute to decreased SOX9 and aggrecan
ConclusionDeficient PSMD11, associated with less phosphorylated FOXO4, promotes impaired proteasomal function in OA chondrocytes, dysregulated chondrocytic homeostasis, and decreased levels of SOX9 mRNA, SOX9 protein, and AGC1 mRNA. Chondrocyte proteasomal impairment may be a therapy target for OA.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - February 18, 2018 Category: Rheumatology Authors: Ramon L Serrano, Liang ‐Yu Chen, Martin K Lotz, Ru Liu‐Bryan, Robert Terkeltaub Tags: Full Length Source Type: research

Enhanced Inflammasome Activity in Systemic Lupus Erythematosus Is Mediated via Type I Interferon –Induced Up‐Regulation of Interferon Regulatory Factor 1
ConclusionProlonged type I IFN exposure, as seen in SLE patients, primes monocytes for robust inflammasome activation in an IRF‐1–dependent manner. IRF‐1 inhibition may serve as a novel target for treatment of SLE‐associated inflammation and organ damage.
Source: Arthritis and Rheumatism - August 8, 2017 Category: Rheumatology Authors: Jianhua Liu, Celine C. Berthier, J. Michelle Kahlenberg Tags: Full Length Source Type: research

Enhanced inflammasome activity in systemic lupus erythematosus is mediated via type I interferon upregulation of interferon regulatory factor 1
Conclusion: Prolonged type I IFN exposure, as seen in SLE patients, primes monocytes for robust inflammasome activation in an IRF1‐dependent manner. IRF1 inhibition may serve as a novel target for treatment of SLE‐associated inflammation and organ damage. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - May 31, 2017 Category: Rheumatology Authors: Jianhua Liu, Celine C. Berthier, J. Michelle Kahlenberg Tags: Full Length Source Type: research

Role of Fibulin 3 in Aging ‐Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage
ConclusionFibulin 3 is specifically expressed in the SZ of articular cartilage and its expression is reduced in aging and OA. Fibulin 3 regulates differentiation of adult progenitor cells, and its aging‐related decline is an early event in the pathogenesis of OA. Preventing aging‐associated loss of fibulin 3 or restoring it to normal levels in SZ chondrocytes has the potential to delay or prevent the onset of OA.
Source: Arthritis and Rheumatism - February 26, 2017 Category: Rheumatology Authors: Akihiko Hasegawa, Tomo Yonezawa, Noboru Taniguchi, Koji Otabe, Yukio Akasaki, Tetsuya Matsukawa, Masahiko Saito, Masashi Neo, Lihua Y. Marmorstein, Martin K. Lotz Tags: Osteoarthritis Source Type: research

Fibulin ‐3 in joint aging and osteoarthritis pathogenesis
Conclusion: Fibulin‐3 is specifically expressed in the SZ of articular cartilage and its expression is reduced in aging and OA. Fibulin‐3 regulates differentiation of adult progenitor cells and its aging‐related decline is an early event in OA pathogenesis. Preventing or restoring aging‐associated loss of fibulin‐3 in SZ chondrocytes has potential to delay or prevent onset of OA. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - September 30, 2016 Category: Rheumatology Authors: Akihiko Hasegawa, Tomo Yonezawa, Noboru Taniguchi, Koji Otabe, Yukio Akasaki, Tetsuya Matsukawa, Masahiko Saito, Masashi Neo, Lihua Y. Marmorstein, Martin K. Lotz Tags: Full Length Source Type: research

Tartrate ‐Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus
Conclusions: Our findings indicate that TRAP and OPN co‐localize and that OPN is a substrate for TRAP in human immune cells. TRAP deficiency in pDCs leads to increased interferon‐alpha production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of Spondyloenchondrodysplasia. Detection of ACP5 missense variants in a lupus cohort suggests that impaired TRAP function may increase susceptibility to sporadic lupus. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - July 6, 2016 Category: Rheumatology Authors: Jie An, Tracy A Briggs, Audrey Dumax ‐vorzet, Marta E Alarcón‐Riquelme, Alexandre Belot, Michael Beresford, Ian Bruce, Claudia Carvalho, Laurence Chaperot, Johan Frostegård, Joel Plumas, Gillian I Rice, Timothy J Vyse, Alice Wiedeman, Yanick J Crow, Tags: Full Length Source Type: research

Tartrate‐Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus
Conclusions: Our findings indicate that TRAP and OPN co‐localize and that OPN is a substrate for TRAP in human immune cells. TRAP deficiency in pDCs leads to increased interferon‐alpha production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of Spondyloenchondrodysplasia. Detection of ACP5 missense variants in a lupus cohort suggests that impaired TRAP function may increase susceptibility to sporadic lupus. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - June 30, 2016 Category: Rheumatology Authors: Jie An, Tracy A Briggs, Audrey Dumax‐vorzet, Marta E Alarcón‐Riquelme, Alexandre Belot, Michael Beresford, Ian Bruce, Claudia Carvalho, Laurence Chaperot, Johan Frostegård, Joel Plumas, Gillian I Rice, Timothy J Vyse, Alice Wiedeman, Yanick J Crow, Tags: Full Length Source Type: research

Histone methylation and STAT3 differentially regulate IL‐6‐induced MMP gene activation in rheumatoid arthritis synovial fibroblasts
Conclusion. We show that the histone methylation and STAT3 regulate spontaneous and IL‐6‐induced MMPs gene activation in RASFs. The network of the chromatin structure and transcription factors may regulate distinct arthritogenic properties of RASFs. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 29, 2015 Category: Rheumatology Authors: Yasuto Araki, Takuma Tsuzuki Wada, Yoshimi Aizaki, Kojiro Sato, Kazuhiro Yokota, Kenta Fujimoto, Yoon‐Taek Kim, Hiromi Oda, Riki Kurokawa, Toshihide Mimura Tags: Full Length Source Type: research

Lupus nephritis IgG induces the expression of calcium/calmodulin‐dependent kinase type IV in podocytes and alters their function
Conclusions: LN IgG enters podocytes and upregulates CaMKIV followed by increased expression of genes known to be linked to podocyte damage and T cell activation. Targeted inhibition of CaMKIV in podocytes may prove of clinical use in patients with LN. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 4, 2015 Category: Rheumatology Authors: Kunihiro Ichinose, Takeshi Ushigusa, Ayako Nishino, Yosikazu Nakashima, Takahisa Suzuki, Yoshiro Horai, Tomohiro Koga, Shin‐ya Kawashiri, Naoki Iwamoto, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Yoko Obata, Kazuo Yamamoto, Tomoki Origuchi, Tomoya Nis Tags: Full Length Source Type: research

Brief Report: Interleukin‐38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus
ConclusionThis is the first study of the function of endogenous IL‐38, and the data suggest that IL‐38 may be protective in SLE. A strong association between IL‐38 and SLE severity suggests that IL‐38 expression is driven by processes linked to SLE pathogenesis. Exploitation of the regulatory effects of IL‐38 may represent a promising therapeutic strategy in SLE.
Source: Arthritis and Rheumatism - November 25, 2015 Category: Rheumatology Authors: Ina Rudloff, Jack Godsell, Claudia A. Nold‐Petry, James Harris, Alberta Hoi, Eric F. Morand, Marcel F. Nold Tags: Systemic Lupus Erythematosus Source Type: research

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β
ConclusionNOX‐4 expression and production were found to be constitutively elevated in SSc skin and cultured SSc dermal fibroblasts. TGFβ1 stimulated NOX‐4 expression in normal and SSc fibroblasts through PKCδ and Smad2/3 signaling pathways. A small‐molecule NOX‐4 inhibitor decreased collagen and fibronectin production by normal and SSc fibroblasts, and NOX‐4 siRNA knockdown reduced ROS and collagen production by SSc fibroblasts. These results demonstrate the involvement of NOX‐4 in SSc‐associated fibrosis and indicate NOX‐4 inhibitors as novel therapeutic approaches for SSc.
Source: Arthritis and Rheumatism - September 23, 2015 Category: Rheumatology Authors: Sonsoles Piera‐Velazquez, Alma Makul, Sergio A. Jiménez Tags: Systemic Sclerosis Source Type: research

Interleukin 38 exerts anti‐inflammatory functions and is associated with disease activity in systemic lupus erythematosus
Conclusion. These data are the first report on the function of endogenous IL‐38, and suggest that IL‐38 may be protective in SLE. A strong association between IL‐38 and SLE severity suggests IL‐38 expression is driven by processes linked to SLE pathogenesis. Exploitation of the anti‐inflammatory properties of IL‐38 should be explored in SLE. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - August 28, 2015 Category: Rheumatology Authors: Ina Rudloff, Jack Godsell, Claudia A. Nold‐Petry, James Harris, Alberta Hoi, Eric F. Morand, Marcel F. Nold Tags: Brief Report Source Type: research

MicroRNA‐9 Promotion of Interleukin‐6 Expression by Inhibiting Monocyte Chemoattractant Protein–Induced Protein 1 Expression in Interleukin‐1β–Stimulated Human Chondrocytes
ConclusionThese findings implicate miR‐9–mediated suppression of MCPIP‐1 in the pathogenesis of OA via up‐regulation of IL‐6 expression in IL‐1β–stimulated human OA chondrocytes.
Source: Arthritis and Rheumatism - July 28, 2015 Category: Rheumatology Authors: Mohammad S. Makki, Abdul Haseeb, Tariq M. Haqqi Tags: Osteoarthritis Source Type: research

Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis
Conclusion. RA activity correlated with decreased synovial fluid pH. This may be due to increased MCT4 expression in RASFs. Silencing MCT4 induced apoptosis in RASFs and reduced the severity of CIA, suggesting that MCT4 is a potential therapeutic target for inflammatory arthritis. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - July 20, 2015 Category: Rheumatology Authors: Wataru Fujii, Yutaka Kawahito, Hidetake Nagahara, Yuji Kukida, Takahiro Seno, Aihiro Yamamoto, Masataka Kohno, Ryo Oda, Daigo Taniguchi, Hiroyoshi Fujiwara, Akika Ejima, Tsunao Kishida, Osam Mazda, Eishi Ashihara Tags: Full Length Source Type: research

Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes
ConclusionThe signaling axis TRAF‐6/TAK‐1/MKK‐4/JNK‐2 mediates IL‐1–induced aggrecanolysis. The level of aggrecanase is controlled by its endocytosis, which may be reduced upon IL‐1 stimulation because of LRP‐1 shedding.
Source: Arthritis and Rheumatism - June 26, 2015 Category: Rheumatology Authors: Heba M. Ismail, Kazuhiro Yamamoto, Tonia L. Vincent, Hideaki Nagase, Linda Troeberg, Jeremy Saklatvala Tags: Chondrocyte Biology Source Type: research