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TNF-α Activates High-Mobility Group Box 1 - Toll-Like Receptor 4 Signaling Pathway in Human Aortic Endothelial Cells
Conclusion: Upon TNF-α stimulation, TLR4 is activated by HMGB1 that is immediately released after the generation of reactive oxygen species, and plays a crucial role in the signal transduction.Cell Physiol Biochem 2016;38:2139-2151
Source: Cellular Physiology and Biochemistry - May 17, 2016 Category: Cytology Source Type: research

Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis
Conclusion: Results provided novel preclinical insights into the chemotherapeutic use of GA by highlighting the importance of p66shc/ROS-p53/Bax pathways in the antitumor effect of GA in malignant melanoma.Cell Physiol Biochem 2016;38:1618-1630
Source: Cellular Physiology and Biochemistry - April 27, 2016 Category: Cytology Source Type: research

Pterostilbene Inhibits the Growth of Human Esophageal Cancer Cells by Regulating Endoplasmic Reticulum Stress
Conclusions: Overall, the results indicate that PTE is a potent anti-cancer pharmaceutical against human esophageal cancer, and the possible mechanism involves the activation of ERS signaling pathways.Cell Physiol Biochem 2016;38:1226-1244
Source: Cellular Physiology and Biochemistry - March 16, 2016 Category: Cytology Source Type: research

Toll-Like Receptor 4/Spleen Tyrosine Kinase Complex in High Glucose Signal Transduction of Proximal Tubular Epithelial Cells
Conclusion: Syk is constitutively associated with TLR4. High glucose induces an immediate, reactive oxygen species-dependent, extracellular release of HMGB-1 which binds to TLR4 and activates it, leading to Syk activation.Cell Physiol Biochem 2015;35:2309-2319
Source: Cellular Physiology and Biochemistry - April 18, 2015 Category: Cytology Source Type: research

High Glucose Promotes Tumor Invasion and Increases Metastasis-Associated Protein Expression in Human Lung Epithelial Cells by Upregulating Heme Oxygenase-1 via Reactive Oxygen Species or the TGF-β1/PI3K/Akt Signaling Pathway
Conclusion: this study is the first to demonstrate that HG treatment of A549 human lung epithelial cells promotes tumor cell invasion and increases metastasis-associated protein expression by up-regulating HO-1 expression via ROS or the TGF-β1/PI3K/Akt signaling pathway.Cell Physiol Biochem 2015;35:1008-1022
Source: Cellular Physiology and Biochemistry - February 5, 2015 Category: Cytology Source Type: research