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Downregulation of N-Acetylglucosaminyltransferase GCNT3 by miR-302b-3p Decreases Non-Small Cell Lung Cancer (NSCLC) Cell Proliferation, Migration and Invasion
Conclusion: miR-302b-3p/GCNT3 axis regulated cell proliferation, migration, and invasion by activating the Erk signaling pathway and epithelial-mesenchymal transition (EMT), which was identified as a potential therapeutic target for NSCLC.Cell Physiol Biochem 2018;50:987 –1004
Source: Cellular Physiology and Biochemistry - October 24, 2018 Category: Cytology Source Type: research

Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma
Conclusion: These results suggest a novel mechanism whereby the PAK1 –CREB axis drives carcinogenesis of squamous-cell carcinomas, and have important implications in the development of targeted therapeutics for squamous-cell lung cancer.Cell Physiol Biochem 2018;50:304 –316
Source: Cellular Physiology and Biochemistry - October 4, 2018 Category: Cytology Source Type: research

Inhibition of ITCH Suppresses Proliferation and Induces Apoptosis of Lung Cancer Cells
Conclusions: Inhibition of ITCH might suppress lung cancer proliferation and invasion via regulation of MMPs, EMT and Bcl2/Bax signaling pathway.Cell Physiol Biochem 2018;48:1703 –1709
Source: Cellular Physiology and Biochemistry - August 3, 2018 Category: Cytology Source Type: research

MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC
Conclusion: We conclude that miR-140 directly suppresses PD-L1 and inhibits the miR-140/PD-L1/cyclin E pathway in NSCLC.Cell Physiol Biochem 2018;46:654 –663
Source: Cellular Physiology and Biochemistry - April 4, 2018 Category: Cytology Source Type: research

MicroRNA-183 Acts as a Tumor Suppressor in Human Non-Small Cell Lung Cancer by Down-Regulating MTA1
Conclusion: Our study indicates that miR-183 down-regulates MTA1 to inhibit the proliferation, EMT, migration and invasion of human NSCLC cells.Cell Physiol Biochem 2018;46:93 –106
Source: Cellular Physiology and Biochemistry - March 23, 2018 Category: Cytology Source Type: research

The LncRNA EPEL Promotes Lung Cancer Cell Proliferation Through E2F Target Activation
Conclusions: Considering its specific effects on cell cycle-related E2F target genes and its significant association with the prognosis of lung cancer patients, we suggest that the transcriptional regulation of EPEL through E2F target genes is potentially a target for the development of novel therapeutic strategies for lung cancer patients.Cell Physiol Biochem 2018;45:1270 –1283
Source: Cellular Physiology and Biochemistry - February 15, 2018 Category: Cytology Source Type: research

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells
Conclusions: Our study has provided new evidence for the role of β-catenin in promoting the growth of lung cancer cells through cooperation with CBP, and suggested that dual targeting of β-catenin and CBP could be a potential therapeutic strategy in lung cancer treatment.Cell Physiol Biochem 2017;44:467 –478
Source: Cellular Physiology and Biochemistry - November 15, 2017 Category: Cytology Source Type: research

Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer
Conclusion: FAL1 may promote tumorigenesis and progression of NSCLC through the PTEN/AKT axis, which could lead to lncRNA-related diagnostics and therapeutics in NSCLC.Cell Physiol Biochem 2017;43:339 –352
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells
Conclusions: Our results evidence eHSP70 as a novel RAGE agonist capable of influence the cross-talk between cancer and immune system cells.Cell Physiol Biochem 2017;42:2507 –2522
Source: Cellular Physiology and Biochemistry - August 22, 2017 Category: Cytology Source Type: research

Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer
Conclusion: These findings indicated that miR-135a promotes cell apoptosis and inhibits cell proliferation, migration, invasion and tumor angiogenesis by targeting IGF-1 gene through the IGF-1/PI3K/Akt signaling pathway in NSCLC.Cell Physiol Biochem 2017;42:1431 –1446
Source: Cellular Physiology and Biochemistry - July 18, 2017 Category: Cytology Source Type: research

Degradation of Mcl-1 through GSK-3 β Activation Regulates Apoptosis Induced by Bufalin in Non-Small Cell Lung Cancer H1975 Cells
Conclusion: Bufalin induced cell apoptosis in H1975 cells may be through downregulation of Mcl-1. Proteasomal degradation of Mcl-1 via GSK-3 β activation was involved in bufalin-induced apoptosis.Cell Physiol Biochem 2017;41:2067 –2076
Source: Cellular Physiology and Biochemistry - April 18, 2017 Category: Cytology Source Type: research

MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung Cancer
Conclusion: miR-497 plays an important role in inhibiting the proliferation of NSCLC by targeting YAP1. Our results suggest that miR-497 is a potential therapeutic target in treating patients with NSCLC.Cell Physiol Biochem 2015;37:342-352
Source: Cellular Physiology and Biochemistry - August 25, 2015 Category: Cytology Source Type: research

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway
Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.Cell Physiol Biochem 2015;36:893-906
Source: Cellular Physiology and Biochemistry - June 9, 2015 Category: Cytology Source Type: research

Clozapine Induces Autophagic Cell Death in Non-Small Cell Lung Cancer Cells
Conclusions: Clozapine inhibits cell proliferation by inducing autophagic cell death in two non-small cell lung carcinoma cell lines. These findings may provide insights into the relationship between clozapine use and the lower incidence of lung cancer among patients with schizophrenia.Cell Physiol Biochem 2015;35:945-956
Source: Cellular Physiology and Biochemistry - February 5, 2015 Category: Cytology Source Type: research

GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9
Conclusions: The expression level of GOLPH3 is correlated with metastasis and prognosis in NSCLC, and GOLPH3 mediates metastasis by regulating the protein levels of MMP-2 and MMP-9 in vitro.Cell Physiol Biochem 2015;35:969-982
Source: Cellular Physiology and Biochemistry - February 5, 2015 Category: Cytology Source Type: research

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