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High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival
Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1 was confirmed to mediate the function of CUL4A in regulating the EMT. The assessment of both CUL4A and mutant TP53 expression will be helpful in predicting colon cancer prognosis.Cell Physiol Biochem 2018;51:2829 –2842
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research

Upregulation of RASSF1A in Colon Cancer by Suppression of Angiogenesis Signaling and Akt Activation
Conclusion: Our results demonstrate for the first time that AGP induces RASSF1A expression in colon cancer cells and is dependent on angiogenesis signaling events. Therefore, our research may facilitate novel therapeutic options for advanced colon cancer therapy.Cell Physiol Biochem 2018;48:1259 –1273
Source: Cellular Physiology and Biochemistry - July 25, 2018 Category: Cytology Source Type: research

The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells
Conclusion: The introduction of miR-495 directly targeted Annexin A3 to inhibit the invasion and EMT of CRC cells by up-regulating p53, and the down-regulation of Annexin A3 was essential for inhibiting the invasion and EMT of CRC cells by overexpressing miR-495. Overall, the re-activation of the miR-495/Annexin A3/ p53 axis may represent a new strategy for overcoming metastasis of CRC.Cell Physiol Biochem 2017;44:1882 –1895
Source: Cellular Physiology and Biochemistry - December 8, 2017 Category: Cytology Source Type: research

β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells
Conclusions: Our study has provided new evidence for the role of β-catenin in promoting the growth of lung cancer cells through cooperation with CBP, and suggested that dual targeting of β-catenin and CBP could be a potential therapeutic strategy in lung cancer treatment.Cell Physiol Biochem 2017;44:467 –478
Source: Cellular Physiology and Biochemistry - November 15, 2017 Category: Cytology Source Type: research

CDC5L Promotes hTERT Expression and Colorectal Tumor Growth
Conclusion: Altogether, the above results demonstrated that CDC5L was positively correlated with hTERT as a key promoter of CRC cells. To some extent, our findings suggest that CDC5L may serve as a novel therapeutic target for human colorectal cancer.Cell Physiol Biochem 2017;41:2475 –2488
Source: Cellular Physiology and Biochemistry - May 4, 2017 Category: Cytology Source Type: research

MicroRNA-124 (MiR-124) Inhibits Cell Proliferation, Metastasis and Invasion in Colorectal Cancer by Downregulating Rho-Associated Protein Kinase 1(ROCK1)
Background/Aims: MiR-124 inhibits neoplastic transformation, cell proliferation, and metastasis and downregulates Rho-associated protein kinase (ROCK1) in Colorectal Cancer (CRC). The aim of this study was to further investigate the roles and interactions of ROCK1 and miR-124 and the effects of knockdown of ROCK1and MiR-124 in human Colorectal Cancer (CRC). Methods: Three Colorectal cancer cell lines (HCT116, HT29 and SW620) and one Human Colonic Mucosa Epithelial cell line (NCM460) were studied. The protein expression of ROCK1 was examined by Western-blot and qRT-PCR were performed to examine the expression levels of ROCK...
Source: Cellular Physiology and Biochemistry - May 9, 2016 Category: Cytology Source Type: research

MicroRNA-140-5p Inhibits the Progression of Colorectal Cancer by Targeting VEGFA
Conclusions: Our results suggested a tumor suppressive role of miR-140-5p in CRC tumorigenesis and progression by targeting VEGFA.Cell Physiol Biochem 2015;37:1123-1133
Source: Cellular Physiology and Biochemistry - September 26, 2015 Category: Cytology Source Type: research