High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival

Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1 was confirmed to mediate the function of CUL4A in regulating the EMT. The assessment of both CUL4A and mutant TP53 expression will be helpful in predicting colon cancer prognosis.Cell Physiol Biochem 2018;51:2829 –2842
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research