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Source: British Journal of Pharmacology
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Total 109 results found since Jan 2013.
Glycogen synthase kinase‐3 (GSK‐3) regulates TGF‐β1‐induced differentiation of pulmonary fibroblasts
Conclusion and implicationWe demonstrate that GSK‐3 signaling regulates TGF‐β1‐induced myofibroblast differentiation by regulating CREB phosphorylation. GSK‐3 may constitute a useful target for treatment of chronic lung diseases.
Source: British Journal of Pharmacology - January 9, 2013 Category: Drugs & Pharmacology Authors: Hoeke A. Baarsma, Lilian H.J.M Engelbertink, Lonneke J. Hees, Mark H. Menzen, Herman Meurs, Wim Timens, Dirkje S. Postma, Huib A.M. Kerstjens, Reinoud Gosens Tags: Research Paper Source Type: research
Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signaling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: H Li, JT Wood, KM Whitten, SK Vadival, S Seng, A Makriyannis, S Avraham, HK Avraham Tags: Research Paper Source Type: research
Il‐4 and Il‐13 Inhibit Il‐1β and Tnf‐α Induced Kinin B1 and B2 Receptors Through a Stat6 Dependent Mechanism
Conclusions And ImplicationsThese data show, for the first time, that IL‐4 and IL‐13 decrease kinin receptors in a STAT6‐dependent mechanism, which can be one important mechanism by which these cytokines exert their anti‐inflammatory effects and impair bone resorption.
Source: British Journal of Pharmacology - January 28, 2013 Category: Drugs & Pharmacology Authors: P P C Souza, A B Brechter, R I Reis, C A S Costa, P Lundberg, U H Lerner Tags: Research Paper Source Type: research
Inhibitory Cross‐talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress‐induced insulin resistance in skeletal muscle
Conclusions And ImplicationsInhibition of ERK signaling pathways by a chemical inhibitor and knockdown of ERK improved AMPK and Akt signalings and reversed ER stress‐induced insulin resistance in L6 myotubes. These findings suggest that ERK signaling plays an important role in the regulation of insulin signals in muscle cells under ER stress.
Source: British Journal of Pharmacology - February 4, 2013 Category: Drugs & Pharmacology Authors: Seung‐Lark Hwang, Yong‐Tae Jeong, Xian Li, Yong Deuk Kim, Lu Yue, Young‐Chae Chang, In‐Kyu Lee, Hyeun Wook Chang Tags: Research Paper Source Type: research
4‐O‐methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21‐mediated suppression of NF‐κB activity
Conclusions and ImplicationMH inhibits growth of human prostate cancer cells through activation of PPARγ, suppression of NF‐κB and arrest of the cell cycle. Thus, MH might be a useful tool for treatment of prostate cancer.
Source: British Journal of Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: NJ Lee, JH Oh, JO Ban, JH Shim, HP Lee, JK Jung, BW Ahn, DY Yoon, SB Han, YW Ham, JT Hong Tags: Research Paper Source Type: research
(E)‐2,4‐bis(p‐hydroxyphenyl)‐2‐butenal has an antiproliferative effect on NSCLC cells induced by p38 MAPK‐mediated suppression of NF‐κB and up‐regulation of TNFRSF10B (DR5)
Conclusions And Implications(E)‐2,4‐bis(p‐hydroxyphenyl)‐2‐butenal induces apoptosis in NSCLC cells by p38 MAPK‐mediated suppression of NF‐κB and activation of TNFRSF10B, which then activates the caspase‐3 and caspase‐9 pathways.
Source: British Journal of Pharmacology - February 25, 2013 Category: Drugs & Pharmacology Authors: Pushpa Saranya Kollipara, Heon Sang Jeong, Sang Bae Han, Jin Tae Hong Tags: Research Paper Source Type: research
IL‐4 and IL‐13 inhibit IL‐1β and TNF‐α induced kinin B1 and B2 receptors through a STAT6‐dependent mechanism
Conclusions and ImplicationsThese data show, for the first time, that IL‐4 and IL‐13 decrease kinin receptors in a STAT6‐dependent mechanism, which can be one important mechanism by which these cytokines exert their anti‐inflammatory effects and impair bone resorption.
Source: British Journal of Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: PPC Souza, AB Brechter, RI Reis, CAS Costa, P Lundberg, UH Lerner Tags: Research Paper Source Type: research
Quercetin and Allopurinol Reduce Liver Thioredoxin‐Interacting Protein to Improve Inflammation and Lipid Accumulation in Diabetic Rats
Conclusions and ImplicationsThese results demonstrate that hepatic TXNIP inhibition by quercetin and allopurinol contributes to the improvement of liver inflammation and lipid accumulation under hyperglycemia condition. Therefore, quercetin and allopurinol targeting hepatic TXNIP may have therapeutic application to prevent type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - May 3, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
Conclusions and ImplicationsInhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - June 21, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
The deactivation of signal transducer and activator of transcription‐3 activation signaling by emodin inhibits growth and induces apoptosis in orthotopic hepatocellular carcinoma model
Conclusions and ImplicationsOverall, our results suggest that emodin is mediating its effects predominantly through inhibition of STAT3 signaling cascade and thus has an enormous potential for the treatment cancers harboring constitutively activated STAT3.
Source: British Journal of Pharmacology - July 15, 2013 Category: Drugs & Pharmacology Authors: Aruljothi Subramaniam, Muthu K. Shanmugam, Tina H. Ong, Feng Li, Ekambaram Perumal, Luxi Chen, Shireen Vali, Taher Abbasi, Shweta Kapoor, Kwang Seok Ahn, Alan Prem Kumar, Kam M Hui, Gautam Sethi Tags: Research Paper Source Type: research
Penta‐O‐galloyl‐β‐D‐glucose ameliorates inflammation by inhibiting MyD88/NF‐κB and MyD88/MAPK signaling pathways
Conclusions And ImplicationsPGG reduces the activation of NF‐κB and MAPK signaling pathways by directly influencing the MyD88 adaptor protein. PGG may ameliorate inflammatory diseases such as colitis.
Source: British Journal of Pharmacology - August 14, 2013 Category: Drugs & Pharmacology Authors: Se‐Eun Jang, Supriya R. Hyam, Jin‐Ju Jeong, Myung Joo Han, Dong‐Hyun Kim Tags: Research Paper Source Type: research
Bleomycin induces endothelial mesenchymal transition through activation of mTOR pathway: a possible mechanism contributing to the sclerotherapy of venous malformations
Conclusions and ImplicationsOur study unmasks the involvement of Slug‐dependent EndoMT in bleomycin‐induced therapeutic effects on endothelial cells and, more importantly, indicates its potential role in the sclerotherapy of VMs.
Source: British Journal of Pharmacology - August 28, 2013 Category: Drugs & Pharmacology Authors: Wei Zhang, Gang Chen, Jian‐Gang Ren, Yi‐Fang Zhao Tags: Research Paper Source Type: research
p90RSK: a new target of Enzastaurin in follicular lymphoma cells
Conclusions and ImplicationsThus, the targeting of p90RSK by Enzastaurin represents a new therapeutic option for follicular lymphoma treatment.
Source: British Journal of Pharmacology - August 28, 2013 Category: Drugs & Pharmacology Authors: S Kheirallah, S Fruchon, L Ysebaert, A Blanc, F Capilla, A Marrot, T AlSaati, F X Frenois, K A Benhadji, JJ Fournié, G Laurent, C Bezombes Tags: Research Paper Source Type: research
Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signalling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: H Li, J T Wood, K M Whitten, S K Vadivel, S Seng, A Makriyannis, H K Avraham Tags: RESEARCH PAPER Source Type: research
Plasminogen‐stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin‐activated cell signalling
Conclusion and implicationsPlasminogen stimulates ASM cell proliferation in a manner mediated by uPA and involving multiple signalling pathways downstream of plasmin. Targeting mediators of plasminogen‐evoked ASM responses, such as uPA or annexin A2, may be useful in the treatment of asthma.
Source: British Journal of Pharmacology - September 22, 2013 Category: Drugs & Pharmacology Authors: A G Stewart, Y C Xia, T Harris, S Royce, J A Hamilton, M Schuliga Tags: Research Paper Source Type: research
