IL‐4 and IL‐13 inhibit IL‐1β and TNF‐α induced kinin B1 and B2 receptors through a STAT6‐dependent mechanism

Conclusions and ImplicationsThese data show, for the first time, that IL‐4 and IL‐13 decrease kinin receptors in a STAT6‐dependent mechanism, which can be one important mechanism by which these cytokines exert their anti‐inflammatory effects and impair bone resorption.

Source: British Journal of Pharmacology - April 25, 2013 Category: Drugs & Pharmacology Authors: PPC Souza, AB Brechter, RI Reis, CAS Costa, P Lundberg, UH Lerner Tags: Research Paper Source Type: research