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GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells
Conclusions: Our data suggested that addition of GLIPR1-ΔTM treatment in PCa cells increases the efficacy of docetaxel and may inhibit the emergence of drug resistance; potentially permitting a decrease of docetaxel dose for patients with mCRPC eliminating its systemic toxicities.
Source: Molecular Cancer - June 19, 2015 Category: Cancer & Oncology Authors: Styliani KaranikaTheodoros KarantanosShinji KurosakaJianxiang WangTakahiro HirayamaGuang YangSanghee ParkAlexei GolstovRyuta TanimotoLikun LiTimothy Thompson Source Type: research

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH
Conclusion: Our finding that tumor cells regulate pHi in response to chemotherapy provides new insights into mechanisms of drug resistance during cancer treatment. Identification of the ZEB1–CA9 signaling axis as a biomarker of poor prognosis in tongue cancer will be valuable in future development of therapeutic strategies aimed at improving treatment efficacy, especially in terms of drug resistance associated with this disease.
Source: Molecular Cancer - April 15, 2015 Category: Cancer & Oncology Authors: Guopei ZhengCong PengXiaoting JiaYixue GuZhijie ZhangYingen DengChengkun WangNan LiJiang YinXiaorong LiuMinying LuHailin TangZhimin He Source Type: research

miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1
Conclusions: In conclusion, for the first time, we identified IGF2BP1 as a direct and functional target of miR-196b and showed that miR-196b overexpression reverses the chemoresistance induced by hypoxia. These results emphasize that the chemoresistance induced by hypoxia is a complex mechanism.
Source: Molecular Cancer - April 8, 2015 Category: Cancer & Oncology Authors: Magali RebucciAudrey SermeusElodie LeonardEdouard DelaiveMarc DieuMaude FransoletThierry ArnouldCarine Michiels Source Type: research

Vascular endothelial growth factor is an autocrine growth factor, signalling through neuropilin-1 in non-small cell lung cancer
Conclusions: Our data demonstrate that VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1. Targeting this VEGF receptor may offer potential as a novel therapeutic approach and also support the evaluation of the role of NP1 as a biomarker predicting sensitivity or resistance to VEGF and VEGFR-targeted therapies in the clinical arena.
Source: Molecular Cancer - February 20, 2015 Category: Cancer & Oncology Authors: Martin BarrSteven GrayKathy GatelyEmily HamsPadraic FallonAnthony DaviesDerek RichardGraham PidgeonKenneth O¿Byrne Source Type: research

The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation
Conclusions: These results demonstrate coupling of CXCR7 with EGFR to regulate proliferation of BrCa cells and suggest an important ligand-independent role of CXCR7 in BrCa growth. Thus, the CXCR7-EGFR axis is a promising target for breast cancer therapy.
Source: Molecular Cancer - August 28, 2014 Category: Cancer & Oncology Authors: Nicole SalazarDaniel MuñozGeorgios KallifatidisRajendra SinghMercè JordàBal Lokeshwar Source Type: research

Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
Conclusion: We could firstly show that SFRP1 strongly correlates with the triple negative breast cancer subtype and secondly, that SFRP1 might be used as a marker stratifying patients to positively respond to neoadjuvant chemotherapy. The mechanisms by which tumor suppressor SFRP1 influences carcinogenic properties of cancer cells do not rely on Wnt signaling, thereby demonstrating the complexity of tumor associated signaling pathways.
Source: Molecular Cancer - July 17, 2014 Category: Cancer & Oncology Authors: Christof BernemannCarolin HülsewigChristian RuckertSarah SchäferLena BlümelGeorg HempelMartin GötteBurkhard GrevePeter BarthLudwig KieselCornelia Liedtke Source Type: research

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
Conclusions: Taken together, these findings highlight mitotic kinases and, in particular, WEE1 as a rational therapeutic target for medulloblastoma.
Source: Molecular Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Peter HarrisSujatha VenkataramanIrina AlimovaDiane BirksIlango BalakrishnanBrian CristianoAndrew DonsonAdrian DubucMichael TaylorNicholas ForemanPhilip ReiganRajeev Vibhakar Source Type: research