miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1

Conclusions:
In conclusion, for the first time, we identified IGF2BP1 as a direct and functional target of miR-196b and showed that miR-196b overexpression reverses the chemoresistance induced by hypoxia. These results emphasize that the chemoresistance induced by hypoxia is a complex mechanism.

Source: Molecular Cancer - April 8, 2015 Category: Cancer & Oncology Authors: Magali RebucciAudrey SermeusElodie LeonardEdouard DelaiveMarc DieuMaude FransoletThierry ArnouldCarine Michiels Source Type: research