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Neurotensin promotes the progression of malignant glioma through NTSR1 and impacts the prognosis of glioma patients
Conclusion: NTS promotes the proliferation and invasion of glioma via the activation of NTSR1. High expression levels of NTS and NTSR1 predict a poor prognosis in glioma patients.
Source: Molecular Cancer - February 3, 2015 Category: Cancer & Oncology Authors: Qing OuyangXueyang GongHualiang XiaoJi ZhouMinhui XuYun DaiLunshan XuHua FengHongjuan CuiLiang Yi Source Type: research

Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor
Conclusions: These data identify RPTP?/? as a cell membrane binding partner for VEGF that regulates angiogenic functions of endothelial cells and suggest that it warrants further validation as a potential target for development of additive or alternative anti-VEGF therapies.
Source: Molecular Cancer - February 3, 2015 Category: Cancer & Oncology Authors: Marina KoutsioumpaEvangelia PoimenidiEvangelia PantazakaChristina TheodoropoulouAngeliki SkouraVasileios MegalooikonomouNelly KiefferJose CourtyShuji MizumotoKazuyuki SugaharaEvangelia Papadimitriou Source Type: research

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Conclusion: Together, our data show a novel role for the WNK1/OSR1/NKCC1 pathway in basal and TMZ-induced glioma migration, and suggest that glioma treatment with TMZ might be improved by drugs that inhibit elements of the WNK1/OSR1/NKCC1 signaling pathway.
Source: Molecular Cancer - February 20, 2014 Category: Cancer & Oncology Authors: Wen ZhuGulnaz BegumKelli PointerPaul ClarkSung-Sen YangShih-Hua LinKristopher KahleJohn KuoDandan Sun Source Type: research

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Conclusions: Our results suggest that development of inhibitors which interfere with CD44-moesin interactions may open a new avenue in the future to mitigate cellular migration in gliomas.
Source: Molecular Cancer - July 15, 2013 Category: Cancer & Oncology Authors: Leroi DeSouzaAjay MattaZia KarimJoydeep MukherjeeX WangOlga KrakovskaGelareh ZadehAbhijit GuhaKW Siu Source Type: research

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma
Conclusions: In summary, we demonstrated that EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas.
Source: Molecular Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Yasufumi KatanasakaYasuo KoderaYuka KitamuraTatsuya MorimotoTomohide TamuraFumiaki Koizumi Source Type: research