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Source: Am J Physiol Cell Ph...
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Total 155 results found since Jan 2013.
TRIM32 triggers β-catenin signaling through ubiquitylation of Axin1 to promote inflammatory factor-induced apoptosis of rat nucleus pulposus cells.
Abstract
The dysregulation of ubiquitin ligase is the cause of many human diseases. Tripartite motif protein 32 (TRIM32) is an E3 ubiquitin ligase whose role in nucleus pulposus (NP) cell apoptosis is unclear. The expression of TRIM family protein and β-catenin in 40 NP tissue samples were detected by RT-PCR. Interleukin (IL)-1β or tumor necrosis factor alpha (TNF-α) were used to treat rat NP cells. Knockdown and overexpression of TRIM 32 were achieved using specific siRNA and recombinant plasmids. Western blot, RT-PCR and flow cytometry were used to assess the expression of TRIM32/β-catenin and the apoptosis ...
Source: Am J Physiol Cell Ph... - January 21, 2020 Category: Cytology Authors: Chen F, Guo Q, Chen Q, Han Z, Zhou X, Wu L, Guo X, Ni B, Yang J Tags: Am J Physiol Cell Physiol Source Type: research
Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension
Am J Physiol Cell Physiol. 2021 Oct 20. doi: 10.1152/ajpcell.00147.2021. Online ahead of print.ABSTRACTPiezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here we report that Piezo1 is significantly upregulated in PAECs from patients with idiopathic PAH and ...
Source: Am J Physiol Cell Ph... - October 20, 2021 Category: Cytology Authors: Ziyi Wang Jiyuan Chen Aleksandra Babicheva Pritesh P Jain Marisela Rodriguez Ramon J Ayon Keeley S Ravellette Linda Wu Francesca Balistrieri Haiyang Tang Xiaomin Wu Tengteng Zhao Stephen M Black Ankit A Desai Joe G N Garcia Xin Sun John Y-J Shyy Daniela V Source Type: research
Mitofusin 2 positively regulates Ca < sup > 2+ < /sup > signaling by tethering the sarcoplasmic reticulum and mitochondria in rat aortic smooth muscle cells
This study strongly suggests that Mfn2 is responsible for SR-mitochondria Ca2+ signaling by tethering mitochondria to SR, thereby regulating ATP production and proliferation of VSMCs.PMID:35704692 | DOI:10.1152/ajpcell.00274.2021
Source: Am J Physiol Cell Ph... - June 15, 2022 Category: Cytology Authors: Sou Inagaki Yoshiaki Suzuki Keisuke Kawasaki Rubii Kondo Yuji Imaizumi Hisao Yamamura Source Type: research
