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Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
In conclusion, our results showed that the pathophysiological factors in type 2 diabetes, including AGEs, were able to induce centrosome amplification. It is suggested that secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway which is upstream of ROCK1 and 14-3-3σ, which is the cell signaling pathway underlying the diabetes-associated centrosome amplification. PMID: 31618077 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - October 15, 2019 Category: Cytology Authors: He QJ, Wang P, Liu Q, Wu Q, Li YF, Wang J, Lee SC Tags: Am J Physiol Cell Physiol Source Type: research

Novel Interaction of Antioxidant-1 with TRAF4: Role in Inflammatory Responses in Endothelial Cells.
We reported that in proinflammatory cytokine TNFa-stimulated endothelial cells (ECs), cytosolic Cu chaperone Atox1 functions as a Cu-dependent transcription factor for NOX organizer p47phox, thereby increasing ROS-dependent inflammatory gene expression. However, the role and mechanism of Atox1 nuclear translocation in inflamed ECs remain unclear. Using enface staining and nuclear fractionation, here we show that Atox1 was localized in the nucleus in inflamed aortas from ApoE-/- mice with Angiotensin II infusion on a high fat diet, while it was found in cytosol in those from control mice. In cultured human ECs, TNFα stimul...
Source: Am J Physiol Cell Ph... - September 24, 2019 Category: Cytology Authors: Das A, Sudhahar V, Ushio-Fukai M, Fukai T Tags: Am J Physiol Cell Physiol Source Type: research

Zinc deficiency up-regulates ET-1 mediated secretion and endothelial cell migration through nuclear HIF-1 translocation.
CONCLUSION: Altogether, the results suggest that zinc deficiency up-regulates ET-1 signaling through HIF-1 activation and stimulates endothelial cell migration suggesting an important role of zinc in the vascular consequences of IH and OSA mediated by the HIF-1-ET- signaling. PMID: 31116583 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - May 21, 2019 Category: Cytology Authors: Morand J, Briancon-Marjollet A, Lemarié E, Gonthier B, Arnaud J, Korichneva I, Godin-Ribuot D Tags: Am J Physiol Cell Physiol Source Type: research

Copper Transporter ATP7A Interacts with IQGAP1, a Rac1 Binding Scaffold Protein: Role in PDGF-induced VSMC Migration and Vascular Remodeling.
Abstract Vascular smooth muscle cell (VSMC) migration contributes to neointimal formation after vascular injury. We previously demonstrated that copper (Cu) transporter ATP7A is involved in PDGF-induced VSMC migration in Cu- and Rac1-dependent manner. Underlying mechanism is still unknown. Here we show that ATP7A interacts with IQGAP1, a Rac1- and receptor tyrosine kinase-binding scaffold proteins, which mediates PDGF-induced VSMC migration and vascular remodeling. In cultured rat aortic SMCs, PDGF stimulation rapidly promoted ATP7A association with IQGAP1 and Rac1, and their translocation to lipid rafts and leadi...
Source: Am J Physiol Cell Ph... - September 26, 2018 Category: Cytology Authors: Ashino T, Kohno T, Sudhahar V, Ash D, Ushio-Fukai M, Fukai T Tags: Am J Physiol Cell Physiol Source Type: research

A2BAR activation attenuates acute lung injury by inhibiting alveolar epithelial cell apoptosis both in vivo and in vitro.
In conclusion, A2BAR activation effectively attenuated OA-induced ALI by inhibiting AEC apoptosis and mitigated H2O2-induced AEC injury by suppressing the p38 and ERK1/2-mediated mitochondrial apoptosis pathway. PMID: 29898376 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 13, 2018 Category: Cytology Authors: Xu X, Zhu Q, Niu F, Zhang R, Wang Y, Wang W, Sun D, Wang X, Wang A Tags: Am J Physiol Cell Physiol Source Type: research

Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence.
In conclusion, these results provide a mechanistic insight into how Nrf2 signaling mediates the anti-senescent and anti-oxidative effects induced by Exendin-4 in VSMCs. PMID: 27488664 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - August 2, 2016 Category: Cytology Authors: Zhou T, Zhang M, Zhao L, Li A, Qin X Tags: Am J Physiol Cell Physiol Source Type: research

PKCδ/Midkine Pathway Drives Hypoxia-induced Proliferation and Differentiation of Human Lung Epithelial Cells.
Abstract Epithelial cells are key players in the pathobiology of numerous hypoxia-induced lung diseases. The mechanisms mediating such hypoxic responses of epithelial cells are not well characterized. Earlier studies reported that hypoxia stimulates protein kinase C (PKC) δ activation in renal cancer cells and an increase in expression of a heparin-binding growth factor, midkine (MK) in lung alveolar epithelial cells. We reasoned that hypoxia might regulate MK levels via PKCδ-dependent pathway and hypothesized that PKCδ-driven MK expression is required for hypoxia-induced lung epithelial cell proliferation and ...
Source: Am J Physiol Cell Ph... - February 5, 2014 Category: Cytology Authors: Zhang H, Okamoto M, Panzhinskiy E, Zawada WM, Das M Tags: Am J Physiol Cell Physiol Source Type: research