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Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK ‐3β in 3xTg‐AD mice
AbstractModerate dietary restriction can ameliorate age ‐related chronic diseases such as Alzheimer's disease (AD) by increasing the expression of neurotrophic factors and promoting neurogenesis in the brain. Glycogen synthase kinase‐3β (GSK‐3β) signaling is essential for the coordination of progenitor cell proliferation and differentiation durin g brain development. The mechanisms by which GSK‐3β is involved in dietary restriction induced neurogenesis and cognitive improvement remain unclear. Six‐month‐old male 3xTg‐AD and wild type mice were fed on alternate days (intermittent fasting, IF) or ad libitum ...
Source: Journal of Neurochemistry - June 22, 2020 Category: Neuroscience Authors: Wei Li, Meijian Wu, Yilin Zhang, Xuemin Wei, Jiankun Zang, Yinghua Liu, Yanping Wang, Cheng ‐Xin Gong, Wei Wei Tags: ORIGINAL ARTICLE Source Type: research

Systems Biology Approaches and Precision Oral Health: A Circadian Clock Perspective
Conclusion Most head and neck pathologies show a broad cellular heterogeneity making it difficult to achieve an accurate diagnosis and efficient treatment (Graf and Zavodszky, 2017; Lo Nigro et al., 2017). Single cell analysis of circadian omics (Lande-Diner et al., 2015; Abraham et al., 2018), may be a crucial tool needed in the future to fully understand the circadian control of head and neck diseases. It becomes more obvious that there is only a small genetic component but a largely unknown epigenetics and/or environmental component for most of the head and neck pathologies (Moosavi and Motevalizadeh Ardekani, 2016; He...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research