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Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner
In conclusion, exenatide significantly improves coronary endothelial function in patients with newly diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK/PI3K-Akt/eNOS pathway via a GLP-1R/cAMP-dependent mechanism.
Source: AJP: Endocrinology and Metabolism - May 31, 2016 Category: Endocrinology Authors: Wei, R., Ma, S., Wang, C., Ke, J., Yang, J., Li, W., Liu, Y., Hou, W., Feng, X., Wang, G., Hong, T. Tags: Articles Source Type: research

Exenatide exerts direct protective effects on endothelial cells through AMPK/Akt/eNOS pathway in a GLP-1 receptor dependent manner.
In conclusion, exenatide significantly improves coronary endothelial function in patients with newly-diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK/PI3K-Akt/eNOS pathway via a GLP-1R/cAMP-dependent mechanism. PMID: 27072494 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - April 11, 2016 Category: Endocrinology Authors: Wei R, Ma S, Wang C, Ke J, Yang J, Li W, Liu Y, Hou W, Feng X, Wang G, Hong T Tags: Am J Physiol Endocrinol Metab Source Type: research

Exenatide can inhibit calcification of human VSMCs through the NF-kappaB/RANKL signaling pathway
Conclusion: GLP-1RA exenatide can inhibit human VSMCs calcification through NF-κB/RANKL signaling.
Source: Cardiovascular Diabetology - November 19, 2014 Category: Cardiology Authors: Jun-Kun ZhanPan TanYan-Jiao WangYi WangJie-Yu HeZhi-Yong TangWu HuangYou-Shuo Liu Source Type: research

Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors.
This study evaluated the antinociceptive activities of geniposide, a presumed small molecule GLP-1R agonist. Geniposide produced concentration-dependent, complete protection against hydrogen peroxide-induced oxidative damage in PC12 and HEK293 cells expressing rat and human GLP-1Rs, but not in HEK293T cells that do not express GLP-1Rs. The orthosteric GLP-1R antagonist exendin(9-39) right-shifted the concentration-response curve of geniposide without changing the maximal protection, with identical pA2 values in both cell lines. Subcutaneous and oral geniposide dose-dependently blocked the formalin-induced tonic response bu...
Source: Neuropharmacology - April 17, 2014 Category: Drugs & Pharmacology Authors: Gong N, Fan H, Ma AN, Xiao Q, Wang YX Tags: Neuropharmacology Source Type: research