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Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway
Tissue Cell. 2022 Aug 6;78:101891. doi: 10.1016/j.tice.2022.101891. Online ahead of print.ABSTRACTTo verify whether propofol alleviates liver ischemia-reperfusion injury (IRI) in mice by regulating Cyp2b10/ Cyp3a25 pathway. The liver I/R injury in vivo and in vitro model was constructed. The serum level of AST, ALT, ALP and ALB was detected using ELISA. The mRNA and protein expression of Cyp2b10 and Cyp3a25 were determined by qRT-PCR and western blot, respectively. The liver cell activity was assessed by MTT assay. The binding between Cyp2b10 and Cyp3a25 was evaluated by online website prediction, CoIP, and cell transfecti...
Source: Tissue and Cell - August 19, 2022 Category: Cytology Authors: Jinli Wu Chao Yu Xianggang Zeng Yini Xu Chengyi Sun Source Type: research

Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
CONCLUSION: It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.PMID:34753510 | DOI:10.1186/s40779-021-00353-0
Source: Cell Research - November 10, 2021 Category: Cytology Authors: Rong-Hui Han He-Meng Huang Hong Han Hao Chen Fei Zeng Xiang Xie Dan-Yong Liu Yin Cai Liang-Qing Zhang Xin Liu Zheng-Yuan Xia Jing Tang Source Type: research