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Specialty: Respiratory Medicine
Drug: Metformin
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Total 3 results found since Jan 2013.
Metformin ‐sensitized NSCLC cells to osimertinib via AMPK‐dependent autophagy inhibition
ConclusionMetformin inhibited autophagy and enhanced osimertinib sensitivity via inducing AMPK activation in a time ‐dependent manner.
Source: The Clinical Respiratory Journal - October 6, 2019 Category: Respiratory Medicine Authors: Hengyi Chen,
Caiyu Lin,
Conghua Lu,
Yubo Wang,
Rui Han,
Li Li,
Shuai Hao,
Yong He Tags: ORIGINAL ARTICLE Source Type: research
Metformin sensitized NSCLC cells to Osimertinib via AMPK ‐dependent autophagy inhibition
ConclusionMetformin inhibited autophagy and enhanced osimertinib sensitivity via inducing AMPK activation in a time ‐dependent manner.
Source: The Clinical Respiratory Journal - September 27, 2019 Category: Respiratory Medicine Authors: Hengyi Chen,
Caiyu Lin,
Conghua Lu,
Yubo Wang,
Rui Han,
Li Li,
Shuai Hao,
Yong He Tags: ORIGINAL ARTICLE Source Type: research
Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation
Conclusion:Metformin suppresses NOX4 expression and ROS production via AMPK activation, resulting in inhibition of TGF-b-induced myofibroblast differentiation. Therefore, metformin may also be used for the treatment of IPF.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Takasaka, N., Araya, J., Kurita, Y., Kobayashi, K., Ito, S., Wakui, H., Yoshii, Y., Minagawa, S., Kojima, J., Hara, H., Numata, T., Shimizu, K., Kawaishi, M., Kaneko, Y., Nakayama, K., Kuwano, K. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research
