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CXCR3 confers sorafenib resistance of HCC cells through regulating metabolic alteration and AMPK pathway.
Authors: Ren Y, Gu YK, Li Z, Xu GZ, Zhang YM, Dong MX, Wang Y, Zhou XB Abstract Currently, the acquired resistance of the hepatocellular carcinoma (HCC) first-line therapeutic agent-sorafenib (SOR) remains a major challenge for HCC management. Recent evidence suggested the association between CXCL/CXCRs chemokines and chemotherapy resistant in cancer cells. Hence, exploring the internal mechanism of CXCRs involved in SOR resistance will help to improve the efficacy of HCC. SOR-resistant HCC cells (Huh7-SOR) were established through escalating concentration of SOR. Glucose consumption, lactate production, intracellu...
Source: American Journal of Translational Research - April 11, 2020 Category: Research Tags: Am J Transl Res Source Type: research

RasGRP1 is a target for VEGF to induce angiogenesis and involved in the endothelial ‐protective effects of metformin under high glucose in HUVECs
AbstractImpaired angiogenesis in endothelial cells is a hallmark of diabetes vascular complications. Ras guanine ‐releasing protein 1 (RasGRP1) is a guanine nucleotide exchange factor for Ras, and its role in endothelial angiogenesis has not been investigated. Given the importance of Ras in vascular endothelial growth factor (VEGF)‐induced angiogenesis, we hypothesized that RasGRP1 may be a critical pathwa y downstream of VEGF and involved in endothelial angiogenesis. Furthermore, we investigate whether RasGRP1‐dependent VEGF signaling was downregulated under high glucose conditions mimicking diabetes and required fo...
Source: IUBMB Life - May 22, 2019 Category: Research Authors: Jing Xu, Miao Liu, Muqiao Yu, Jiayi Shen, Jiecan Zhou, Jinglei Hu, Yong Zhou, Wei Zhang Tags: Research Communication Source Type: research

Anticancer Activity of Metformin, an Antidiabetic Drug, Against Ovarian Cancer Cells Involves Inhibition of Cysteine-Rich 61 (Cyr61)/Akt/Mammalian Target of Rapamycin (mTOR) Signaling Pathway.
CONCLUSIONS Taken together, we concluded that metformin exhibits anticancer effects and Cyr61 acts as a direct target for metformin in ovarian cancer cells. PMID: 30171812 [PubMed - in process]
Source: Medical Science Monitor - September 2, 2018 Category: Research Tags: Med Sci Monit Source Type: research

PGC-1 mediates the regulation of metformin in muscle irisin expression and function.
CONCLUSION: Our study demonstrates that Metformin stimulates irisin secretion from skeletal muscle into the circulation system of obese mice, and that PGC-1α is a critical regulator in this process. PMID: 26692929 [PubMed]
Source: American Journal of Translational Research - December 26, 2015 Category: Research Tags: Am J Transl Res Source Type: research