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Total 22 results found since Jan 2013.
A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons RESOURCES
Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is caused in part by mosquito RNA interference (RNAi) pathways that generate antiviral small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). RNAi also maintains genome integrity by potently repressing mosquito transposon activity in the germline and soma. However, viral and transposon small RNA regulatory pathways have not been systematically examined together in mosquitoes. Therefore, we developed an integrated mosquito small RNA genomics (MSRG) resource that anal...
Source: Genome Research - February 12, 2021 Category: Genetics & Stem Cells Authors: Ma, Q., Srivastav, S. P., Gamez, S., Dayama, G., Feitosa-Suntheimer, F., Patterson, E. I., Johnson, R. M., Matson, E. M., Gold, A. S., Brackney, D. E., Connor, J. H., Colpitts, T. M., Hughes, G. L., Rasgon, J. L., Nolan, T., Akbari, O. S., Lau, N. C. Tags: RESOURCES Source Type: research
Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2 γ-mediated pre-initiation complex
CONCLUSIONS: These findings demonstrated that CySC lineage eIF5, together with eIF1A or eIF2γ, mediates soma-germline communications for the stem cell niche homeostasis in Drosophila testes, providing new insights for the prevention of TGCTs.PMID:35883200 | DOI:10.1186/s13287-022-03025-5
Source: Cell Research - July 26, 2022 Category: Cytology Authors: Zhiran Li Yunhao Wu Yangbo Fu Xia Chen Xi Zhao Xiaolong Wu Yajuan Lu Hui He Cong Shen Bo Zheng Jun Yu Fei Sun Source Type: research
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
Neoplasia. 2022 Sep 23;33:100837. doi: 10.1016/j.neo.2022.100837. Online ahead of print.ABSTRACTKRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 haploinsufficiency suppresses both KRASG12D-driven pancreatic and lung tumorigenesis, we seek to determine the underlying mechanisms. Here...
Source: Neoplasia - September 26, 2022 Category: Cancer & Oncology Authors: Dat P Ha Bo Huang Han Wang Daisy Flores Rangel Richard Van Krieken Ze Liu Soma Samanta Nouri Neamati Amy S Lee Source Type: research
