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Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF- β1-NOX4 Pathway
AbstractSecreted protein acidic and rich in cysteine (SPARC) has a close association with inflammatory response and oxidative stress in tissues and is widely expressed in intracranial aneurysms (IAs), especially in smooth muscle cells. Therefore, it is inferred that SPARC might be involved in the formation and development of IAs through the inflammatory response pathway or oxidative stress pathway. The aim of this study is to investigate the pathological mechanism of SPARC in oxidative stress, inflammation, and apoptosis during the formation of IAs, as well as the involvement of TGF- β1 and NOX4 molecules. Human brain vas...
Source: Journal of Molecular Neuroscience - June 2, 2020 Category: Neuroscience Source Type: research

Cytotoxic and genotoxic effects mediated by M2 muscarinic receptor activation in human glioblastoma cells
In conclusion, in addition to a cytostatic effect previously described, in the present study we have better characterized the mechanisms causing the cytotoxic effects and the apoptotic cell death in glioblastoma cells after M2 receptor activation. These data allow to consider this receptor a new interesting therapeutic tool for the glioblastoma treatment.
Source: Neurochemistry International - October 10, 2015 Category: Neuroscience Source Type: research

PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes
Publication date: 22 January 2015 Source:Neuroscience, Volume 284 Author(s): H. Chen , M. Tian , L. Jin , H. Jia , Y. Jin PUMA (p53-upregulated modulator of apoptosis), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and p53-independent forms of apoptosis. PUMA has been invovled in the onset and progress of several diseases, including cancer, acquired immunodeficiency syndrome, and ischemic brain disease. Although many studies have shown that ischemia and reperfusion (I/R) can induce the apoptosis of astrocytes, the role of PUMA in I/R-mediated apoptosis of cerebral astrocyte apoptosis remain...
Source: Neuroscience - November 25, 2014 Category: Neuroscience Source Type: research

l-Carnitine attenuates H2O2-induced neuron apoptosis via inhibition of endoplasmic reticulum stress
Publication date: December 2014 Source:Neurochemistry International, Volume 78 Author(s): Junli Ye , Yantao Han , Xuehong Chen , Jing Xie , Xiaojin Liu , Shunhong Qiao , Chunbo Wang Both oxidative stress and endoplasmic reticulum stress (ER stress) have been linked to pathogenesis of neurodegenerative diseases. Our previous study has shown that l-carnitine may function as an antioxidant to inhibit H2O2-induced oxidative stress in neuroblastoma SH-SY5Y cells. To further explore the neuroprotection of l-carnitine, here we study the effects of l-carnitine on the ER stress response in H2O2-induced SH-SY5Y cell injury. Our re...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research