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LIPUS suppressed LPS ‐induced IL‐1α through the inhibition of NF‐κB nuclear translocation via AT1‐PLCβ pathway in MC3T3‐E1
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Source: Journal of Cellular Physiology - January 6, 2017 Category: Cytology Authors: Mayu Nagao, Natsuko Tanabe, Soichiro Manaka, Masako Naito, Kumiko Nakai, Tadahiro Takayama, Takayuki Kawato, Go Torigoe, Jumpei Sekino, Naoya Tsukune, Masao Maeno, Naoto Suzuki, Shuichi Sato Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

High Potassium Promotes Mutual Interaction between (Pro)Renin Receptor and the Local Renin-Angiotensin-Aldosterone System in Rat IMCD Cells.
Abstract (Pro)renin receptor (PRR) is predominantly expressed in the collecting duct (CD) with unclear functional implication. It is not known whether CD PRR is regulated by high potassium (HK). Here, we aimed to investigate the effect of HK on PRR expression and its role in regulation of aldosterone synthesis and release in the CD. In primary rat inner medullary CD cells, HK augmented PRR expression and soluble PPR (sPRR) release in a time- and dose- dependent manner, which was attenuated by PRR siRNA, eplerenone, and losartan. HK upregulated aldosterone release in parallel with an increase of CYP11B2 (cytochrome...
Source: Am J Physiol Cell Ph... - August 16, 2016 Category: Cytology Authors: Xu C, Fang H, Zhou L, Lu A, Yang T Tags: Am J Physiol Cell Physiol Source Type: research

Enhanced expression of Gqα and PLCβ1 proteins contribute to vascular smooth muscle cell Hypertrophy in SHR: role of endogenous angiotensin II and endothelin-1.
Abstract Vascular Gqα signaling has been shown to contribute to cardiac hypertrophy. In addition, angiotensin II (Ang II) was shown to induce VSMC hypertrophy through Gqα signaling, however, the studies on the role of Gqα and PLCβ1 proteins in VSMC hypertrophy in animal model are lacking. The present study was therefore undertaken to examine the role of Gqα/PLCβ1 proteins and the signaling pathways in VSMC hypertrophy using spontaneously hypertensive rats (SHR). VSMC from 16 week-old SHR and not from 12 week-old SHR exhibited enhanced levels of Gqα/PLCβ1 proteins as compared to age-matched Wistar-Kyoto (WK...
Source: American Journal of Physiology. Cell Physiology - April 23, 2014 Category: Cytology Authors: Atef ME, Anand-Srivastava MB Tags: Am J Physiol Cell Physiol Source Type: research

Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species
Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely blocked ...
Source: Journal of Cellular Physiology - December 17, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research

Angiotensin II activation of canonical transient receptor potential‐6 (TRPC6) channels in rat podocytes requires generation of reactive oxygen species
Abstract Angiotensin II (AII) plays a major role in the progression of chronic kidney diseases. Podocytes are essential components of the ultrafiltration apparatus, and are targets for AII signaling. AII has been shown to increase generation of reactive oxygen species (ROS) in podocytes. Canonical transient receptor potential‐6 (TRPC6) channels stimulate Ca2+ influx in podocytes, and have been implicated in glomerular disease. We observed that AII increased cationic currents in rat podocytes in an isolated glomerulus preparation in which podocytes are still attached to the underlying capillary. This effect was completely...
Source: Journal of Cellular Physiology - September 3, 2013 Category: Cytology Authors: Marc Anderson, Hila Roshanravan, Justin Khine, Stuart E. Dryer Tags: Original Research Article Source Type: research