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A Newly Synthesized platinum-based Compound (PBC-II) Increases Chemosensitivity of HeLa Ovarian Cancer Cells Via Inhibition of Autophagy
Publication date: Available online 16 October 2019Source: Saudi Pharmaceutical JournalAuthor(s): Moureq Rashed Alotaibi, Homood Moqbel As Sobeai, Faten Abdullah Alaqil, Mashal Almutairi, Khalid Alhazzani, Adam A.A. Sulaiman, Anvarhusein A. Isab, Nasser Hadal AlotaibiAbstractthere are many mechanisms of resistance, chemoresistance of HeLa cells to anti-cancer agents seems to be autophagy-mediated. While using very effective anti-cancers such as Doxorubicin and cisplatin, cells overcome the cytotoxicity of these drugs through promotion of what so-called cytoprotective autophagy. Here in this study, we sought to introduce a n...
Source: Saudi Pharmaceutical Journal - October 17, 2019 Category: Drugs & Pharmacology Source Type: research

Identification of FBXW7 α-regulated genes in M1-polarized macrophages in colorectal cancer by RNA sequencing.
CONCLUSION: These results prove that the FBXW7α/miR-205 axis plays an important role in TAM polarization and could facilitate further exploration of its molecular mechanism. PMID: 31423512 [PubMed - in process]
Source: Saudi Medical Journal - August 20, 2019 Category: Middle East Health Tags: Saudi Med J Source Type: research

miRNA-21 Inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway
ConclusionThe suppression of microRNA-21 inhibits the progression of EOC profoundly. In EOC, miR-21 is negatively correlated with the expression of PTEN gene.
Source: Saudi Journal of Biological Sciences - August 10, 2019 Category: Biology Source Type: research

FoxM1 is an independent poor prognostic marker and therapeutic target for advanced Middle Eastern breast cancer.
In this study, we explored the prevalence and clinical implication of FoxM1 overexpression in Saudi breast cancer. FoxM1 protein overexpression was seen in 79% (770/975) of BC tissues and was associated with aggressive clinical parameters such as younger age (< 30 yrs) (p = 0.0172), high grade (p < 0.0001), mucinous histology (p < 0.0001) and triple negative phenotype (p < 0.0001). Overexpression of FoxM1 was significantly associated with activated AKT (p < 0.0001), Ki67 expression (p < 0.0001), VEGF (p < 0.0001), MMP-9 (p < 0.0001), XIAP (p < 0.0001) and Bcl-xL (p = 0.0300). Importantly, FoxM1 o...
Source: Oncotarget - May 2, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research