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Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Exploiting altered patterns of choline kinase-alpha expression on human prostate tissue to prognosticate prostate cancer
Conclusions Increased expression of CHKA, detectable by IHC, is seen in malignant lesions. This relatively simple cost-effective technique (IHC) could complement current diagnostic procedures for prostate cancer and, therefore, warrants further investigation.
Source: Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Challapalli, A., Trousil, S., Hazell, S., Kozlowski, K., Gudi, M., Aboagye, E. O., Mangar, S. Tags: Immunology (including allergy), Prostate cancer, Urological cancer Original article Source Type: research