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Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

α7 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2/STAT3 signaling pathway.
Authors: Fei R, Zhang Y, Wang S, Xiang T, Chen W Abstract Considerable evidence has implied that α7 nicotinic receptor subtypes play an important role in chronic inflammatory and neuropathic pain signaling. The aim of the present study was to determine the role of endogenous α7nAChR signaling in tumor-associated macrophages (TAMs) in human colorectal cancer (CRC) metastasis and prognosis. α7nAChR expression in primary tumor cells and adjacent stroma cells especially in TAMs in 51 CRC patients was observed. Using a human monocyte THP-derived macrophages (TMs) with α7nAChR-siRNA knockdown (TMα7-/-) and a CRC ce...
Source: Oncology Reports - September 14, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy.
CONCLUSIONS: VAC14 should be prioritized for further validation of its potential role as a predictor of docetaxel-induced neuropathy and biomarker for treatment individualization. PMID: 27143689 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - May 2, 2016 Category: Cancer & Oncology Authors: Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel JN, Halabi S, Furukawa Y, Wheeler HE, Sibley A, Lassiter C, Weisman LS, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz D, Friedman PN, Mahoney JF, Carducci MA, Ke Tags: Clin Cancer Res Source Type: research

Abstract P2-05-26: Focal adhesion kinase is required for efficient tumor-induced osteoclastogenesis via control of macrophage colony stimulating factor expression
Breast cancer most commonly metastasizes to bone where metastases cause the potentiation of the vicious cycle. During this process, breast cancer bone metastases inhibit osteoblasts from forming new bone, while also activating osteoclasts to degrade bone. This in turn causes release of bone-matrix bound growth factors which propagate tumor growth. The overall net bone destruction can lead to significant adverse clinical consequences for patients including fractures or substantial pain. While agents such as bisphosphonates or the monoclonal antibody to RANKL denosumab, both of which inhibit the osteolytic activity of osteoc...
Source: Cancer Research - February 18, 2016 Category: Cancer & Oncology Authors: Landon, K., Howe, G., Zhao, H., Addison, C. Tags: Poster Session Abstracts Source Type: research

Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B.
Authors: Zheng J, Lee HL, Ham YW, Song HS, Song MJ, Hong JT Abstract Bee venom (BV) has been used as a traditional medicine to treat arthritis, rheumatism, back pain, cancerous tumors, and skin diseases. However, the effects of BV on the colon cancer and their action mechanisms have not been reported yet. We used cell viability assay and soft agar colony formation assay for testing cell viability, electro mobility shift assay for detecting DNA binding activity of nuclear factor kappa B (NF-κB) and Western blotting assay for detection of apoptosis regulatory proteins. We found that BV inhibited growth of colon canc...
Source: Oncotarget - November 14, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Abstract 5010: Osteoblasts-derived WISP-1 increases prostate cancer metastasis through VCAM-1 upregulation
The skeleton is the most common metastatic site for prostate cancer, and increases the risk of intractable bone pain. Therefore, study of the interactions between prostate cancer and the bone microenvironment is very important. Wnt-1 induced secreted protein 1 (WISP-1) belongs to the CCN family (CTGF/CYR61/NOV), which plays an important role in bone formation and many cellular processes. However, the effects of WISP-1 on the prostate cancer metastasis are not clearly understood. First, we found that WISP-1 presents in osteoblast-condition medium (OB-CM), which increases prostate cancer cell migration and invasion. In addit...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Chang, A.-C., Wang, S.-W., Tang, C.-H. Tags: Tumor Biology Source Type: research

Investigation of Schwann Cells at Neoplastic Cell Sites Before the Onset of Cancer Invasion
Conclusions Schwann cells have particular and specific affinity to cancer cells. Emergence of Schwann cells in the premalignant phase of pancreatic and colon cancer implies that, in contrast with the traditional assumption, nerves—and not cancer cells—migrate first during NI.
Source: JNCI - August 8, 2014 Category: Cancer & Oncology Authors: Demir, I. E., Boldis, A., Pfitzinger, P. L., Teller, S., Brunner, E., Klose, N., Kehl, T., Maak, M., Lesina, M., Laschinger, M., Janssen, K.-P., Algul, H., Friess, H., Ceyhan, G. O. Tags: Article Source Type: research