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Specialty: Neurology
Condition: Pain
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Total 52 results found since Jan 2013.
Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice
ConclusionOur study elucidates a novel signaling cascade wherein adiponectin stimulates TG Cav3.2 channels via adipoR1 coupled to a novel CK2 α-dependent PKCβ1. This process induces neuronal hyperexcitability and pain hypersensitivity. Insight into adipoR-Cav3.2 signaling in sensory neurons provides attractive targets for pain treatment.
Source: The Journal of Headache and Pain - August 25, 2023 Category: Neurology Source Type: research
MG53 ameliorates nerve injury induced neuropathic pain through the regulation of Nrf2/HO-1 signaling in rats
In this study, we aimed to explore the role of MG3 in neuropathic pain after chronic constriction injury (CCI) to the sciatic nerve in rats. To explore the mechanism of MG53 regulating the development of neuropathic pain, the rats was injected (intrathecal injection) of recombinant human MG53 (rhMG53) protein and/or nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA after CCI. Mechanical allodynia or thermal hyperalgesia was assessed by the 50% paw withdrawal threshold (PWT) or the paw withdrawal latency (PWL). The target molecules was detected using western blotting (WB), immunofluorescence (IF), quantitative real-t...
Source: Brain Research - May 11, 2023 Category: Neurology Authors: Xuan-Zhi Zhu Jing-Qiong Wang Yao-Hua Wu Source Type: research
Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors
ConclusionThese results suggest that tyramine induces Kv1.4-mediatedIA suppression through stimulation of TAAR1 coupled to the Gβγ-dependent PKCθ signaling cascade, thereby enhancing TG neuronal excitability and mechanical pain sensitivity. Insight into TAAR1 signaling in sensory neurons provides attractive targets for the treatment of headache disorders such as migraine.
Source: The Journal of Headache and Pain - May 8, 2023 Category: Neurology Source Type: research
Calcitonin gene-related peptide and its receptor plays important role in nociceptive regulation in the arcuate nucleus of hypothalamus of rats with inflammatory pain
This study shed light upon CGRP and its receptor interaction might be valuable strategies for the alleviation of inflammatory pain.PMID:36804439 | DOI:10.1016/j.bbr.2023.114351
Source: Brain Research - February 22, 2023 Category: Neurology Authors: Laixi Luo Wentao Qi Yuyan Zhang Jingyi Wang Li Guo Milin Wang Hong-Bo Wang Long-Chuan Yu Source Type: research
Activation of Double-Stranded RNA –Activated Protein Kinase in the Dorsal Root Ganglia and Spinal Dorsal Horn Regulates Neuropathic Pain Following Peripheral Nerve Injury in Rats
AbstractDouble-stranded RNA (dsRNA) –activated kinase (PKR) is an important component in inflammation and immune dysfunction. However, the role of PKR in neuropathic pain remains unclear. Here, we showed that lumbar 5 spinal nerve ligation (SNL) led to a significant increase in the level of phosphorylated PKR (p-PKR) in both the dor sal root ganglia (DRG) and spinal dorsal horn. Images of double immunofluorescence staining revealed that p-PKR was expressed in myelinated A-fibers, unmyelinated C-fibers, and satellite glial cells in the DRG. In the dorsal horn, p-PKR was located in neuronal cells, astrocytes, and microglia...
Source: Neurotherapeutics - June 2, 2022 Category: Neurology Source Type: research
Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord
In conclusion, the study indicates a novel mechanism that acupuncture produces analgesic effects at least partially via APN/AdipoR2-AMPK pathway in the spinal cord.PMID:34562596 | DOI:10.1016/j.bbi.2021.09.010
Source: Brain, Behavior, and Immunity - September 25, 2021 Category: Neurology Authors: Zhipeng Ning Pan Gu Jialing Zhang Chi Wai Cheung Lixing Lao Haiyong Chen Zhang-Jin Zhang Source Type: research
KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats
Brain Behav Immun. 2021 Aug 28;98:265-282. doi: 10.1016/j.bbi.2021.08.231. Online ahead of print.ABSTRACTThe lysine specific demethylase 6B (KDM6B) has been implicated as a coregulator in the expression of proinflammatory mediators, and in the pathogenesis of inflammatory and arthritic pain. However, the role of KDM6B in neuropathic pain has yet to be studied. In the current study, the neuropathic pain was determined by assessing the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) following lumbar 5 spinal nerve ligation (SNL) in male rats. Immunohistochemistry, Western blotting, qRT-PCR, and chromatin immu...
Source: Brain, Behavior, and Immunity - August 31, 2021 Category: Neurology Authors: Liren Li Liying Bai Kangli Yang Jian Zhang Yan Gao Mingjun Jiang Yin Yang Xuan Zhang Li Wang Xueli Wang Yiming Qiao Ji-Tian Xu Source Type: research
