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Alginate-based drug carrier systems to target inflammatory bowel disease: A review
Int J Biol Macromol. 2023 Jun 17:125472. doi: 10.1016/j.ijbiomac.2023.125472. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is an inflammatory disorder that affects the gastrointestinal tract. IBD has become an increasingly common condition in both developed and developing nations over the last few decades, owing to a variety of factors like a rising population and diets packed with processed and junk foods. While the root pathophysiology of IBD is unknown, treatments are focused on medications aimed to mitigate symptoms. Alginate (AG), a marine-derived polysaccharide, is extensively studied for its biocom...
Source: International Journal of Biological Macromolecules - June 19, 2023 Category: Biochemistry Authors: Dinakar Swastha Nambolan Varsha Suresh Aravind Kavassery Balasubramanian Samyuktha Muruganandam Mohaneswari Yokesh Akshad Balde Bakthavatchalam Loganathan Ayilya Soottawat Benjakul Se-Kwon Kim Rasool Abdul Nazeer Source Type: research

BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research

In  vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration
Cell Stem Cell. 2022 Jan 24:S1934-5909(22)00001-7. doi: 10.1016/j.stem.2022.01.001. Online ahead of print.ABSTRACTIdentifying new pathways that regulate mammalian regeneration is challenging due to the paucity of in vivo screening approaches. We employed pooled CRISPR knockout and activation screening in the regenerating liver to evaluate 165 chromatin regulatory proteins. Both screens identified the imitation-SWI chromatin remodeling components Baz2a and Baz2b, not previously implicated in regeneration. In vivo sgRNA, siRNA, and knockout strategies against either paralog confirmed increased regeneration. Distinct BAZ2-spe...
Source: Cell Stem Cell - January 29, 2022 Category: Stem Cells Authors: Yuemeng Jia Lin Li Yu-Hsuan Lin Purva Gopal Shunli Shen Kejin Zhou Xueliang Yu Tripti Sharma Yu Zhang Daniel J Siegwart Joseph M Ready Hao Zhu Source Type: research

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research