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Condition: Inflammatory Bowel Disease
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Total 147 results found since Jan 2013.
Alginate-based drug carrier systems to target inflammatory bowel disease: A review
Int J Biol Macromol. 2023 Jun 17:125472. doi: 10.1016/j.ijbiomac.2023.125472. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is an inflammatory disorder that affects the gastrointestinal tract. IBD has become an increasingly common condition in both developed and developing nations over the last few decades, owing to a variety of factors like a rising population and diets packed with processed and junk foods. While the root pathophysiology of IBD is unknown, treatments are focused on medications aimed to mitigate symptoms. Alginate (AG), a marine-derived polysaccharide, is extensively studied for its biocom...
Source: International Journal of Biological Macromolecules - June 19, 2023 Category: Biochemistry Authors: Dinakar Swastha Nambolan Varsha Suresh Aravind Kavassery Balasubramanian Samyuktha Muruganandam Mohaneswari Yokesh Akshad Balde Bakthavatchalam Loganathan Ayilya Soottawat Benjakul Se-Kwon Kim Rasool Abdul Nazeer Source Type: research
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways
CONCLUSION: Our study demonstrated that spermidine rescues intestinal barrier defects in mice with colitis via the AhR-Nrf2 and AhR-STAT3 pathways, providing a potential therapeutic agent for IBD and other conditions associated with dysregulated gut barrier function.PMID:37104918 | DOI:10.1016/j.intimp.2023.110166
Source: International Immunopharmacology - April 27, 2023 Category: Allergy & Immunology Authors: Bing Yan Xinjie Mao Shasha Hu Shimin Wang Xiaochen Liu Jing Sun Source Type: research
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in an...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
Photoaffinity labelling-based chemoproteomic strategy identifies PEBP1 as the target of ethyl gallate against macrophage activation
Chem Commun (Camb). 2023 Jan 4. doi: 10.1039/d2cc05440j. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease of the colon with an unmet need for therapeutic targets. Ethyl gallate (EG) is a natural small molecule for UC treatment, but its cellular target is unknown. By labelling EG with a diazirine photocrosslinker and a click chemistry handle, we identified phosphatidyl-ethanolamine binding protein1 (PEBP1) as a direct cellular target of EG by forming hydrogen bonds with Asp70 and Tyr120. In particular, hydrogen/deuterium exchange mass spectrometry indicated that EG induced the sequence (resid...
Source: Chemical Communications - January 4, 2023 Category: Chemistry Authors: Wei Yu Min Liao Yang Chen Rui Xue Xiao-Meng Shi Dan Liu Fang-Fang Zhuo Hui Tang Zhi-Yuan Lu Peng-Fei Tu Bo Han Xin Jia Ke-Wu Zeng Source Type: research
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1
CONCLUSIONS: We found that BMSCs can induce Treg differentiation by inhibiting the Akt/mTOR pathway via PD-L1; this significantly improved symptoms and pathology in our ulcerative colitis rat models.PMID:36261682 | DOI:10.1007/s10529-022-03307-1
Source: Biotechnology Letters - October 19, 2022 Category: Biotechnology Authors: Fei Gao Dandan Cui Dongmei Zuo Zhexing Shou Jia Yang Ting Yu Yujin Liu Si Chu Feng Zhu Chunzhu Wei Source Type: research
CYP24A1 Involvement in Inflammatory Factor Regulation Occurs via the Wnt Signaling Pathway
ConclusionTaken together, this study suggests that inflammatory factors may increase CYP24A1 expressionvia NF- κB pathway activation, which in turn stimulates Wnt signaling.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 17, 2022 Category: Research Source Type: research
Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF- α siRNA mitigates gut inflammation < em > via < /em > inhibiting the differentiation of CD4 < sup > + < /sup > T cells
Nanoscale. 2022 Sep 28. doi: 10.1039/d1nr05644a. Online ahead of print.ABSTRACTProinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) are critical mediators of inflammatory bowel disease pathogenesis, and are important targets to restore intestinal homeostasis. Herein, we present the engineering and screening of gemini lipid nanoparticles (GLNPs) for siRNA delivery to colon epithelial cells, macrophages and dendritic cells, and their ability to deliver siRNA therapeutics to the inflamed gastrointestinal tract. We synthesized eight gemini cationic lipids by tethering two lithocholic acid molecules through 3'-hy...
Source: Cell Research - September 28, 2022 Category: Cytology Authors: Priyanka Verma Amit Arora Kajal Rana Devashish Mehta Raunak Kar Vikas Verma C V Srikanth Veena S Patil Avinash Bajaj Source Type: research
Indirubin regulates T cell differentiation by promoting αVβ8 expression in bone marrow-derived dendritic cells to alleviate inflammatory bowel disease
This study aimed to isolate bone marrow-derived dendritic cells (BMDCs) using lipopolysaccharide (LPS) to obtain mature DCs (mDCs). The expression of CD80, CD86, CD40, and MHC-II was detected using flow cytometry after treatment with IDRB. αVβ8 siRNA was used to knock down αVβ8 in mDCs, and the expression of CD80, CD86, CD40, and MHC-II was detected. Meanwhile, DCs were co-cultured with T cells. Then, T cell differentiation was detected using flow cytometry, and the cytokine levels were detected using enzyme-linked immunosorbent assay. The animal model of dextran sulfate sodium (DSS)-induced inflammatory bowel disease ...
Source: Cell Research - September 26, 2022 Category: Cytology Authors: Tao Zhang Hong Peng Yunxiang Li Xiaoqing Zhou Wenfeng Pu Yan Zhang Zhonghan Du Fuxia Wei Siqing Li Qian Zhou Source Type: research
siRNA-based nanotherapeutics as emerging modalities for immune-mediated diseases: A preliminary review
This study will pave the way for new avenues of research into the diagnosis and treatment of IMDs.PMID:35830711 | DOI:10.1002/cbin.11841
Source: Cell Biology International - July 13, 2022 Category: Cytology Authors: Saman Sargazi Rabia Arshad Reza Ghamari Abbas Rahdar Ali Bakhshi Sonia Fathi Karkan Narges Ajalli Muhammad Bilal Ana M D íez-Pascual Source Type: research
