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Heat shock transcription factor 2 predicts mucosal healing and promotes mucosal repair of ulcerative colitis.
Conclusions: HSF2 may be a predictor of MH in UC patients. HSF2 inhibited inflammation and promoted mucosal repair. PMID: 32538201 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 18, 2020 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aime...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Hypoxia induces production of citrullinated proteins in human fibroblast ‐like synoviocytes through regulating HIF1α
This article is protected by copyright. All rights reserved.
Source: Scandinavian Journal of Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Ruohan Yu, Changhong Li, Lin Sun, Leilei Jian, Zhenzhen Ma, Jinxia Zhao, Xiangyuan Liu Tags: Regular Article Source Type: research