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TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt Pathway in Steroid ‐Associated Osteonecrosis
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - August 31, 2016 Category: Orthopaedics Authors: Jie Zhao, Xin ‐long Ma, Jian‐xiong Ma, Lei Sun, Bin Lu, Ying Wang, Guo‐sheng Xing, Yan Wang, Ben‐chao Dong, Li‐yan Xu, Ming‐Jie Kuang, Lin Fu, Hao‐hao Bai, Yue Ma, Wei‐lin Jin Tags: Original Article Source Type: research

P53 Dependent Mitochondrial Permeability Transition Pore Opening Is Required for Dexamethasone‐Induced Death of Osteoblasts
Prolonged or overdose glucocorticoids (GCs) usage is the common cause of osteoporosis. In the present study, we studied the cellular mechanism of dexamethasone (Dex)‐induce osteoblast cell death by focusing on the role of mitochondrial permeability transition pore (mPTP). In cultured osteoblastic MC3T3‐E1 cells, Dex‐induced mPTP opening, which was demonstrated by mitochondrial membrane potential (MPP) decrease, cyclophilin‐D (CyPD)–adenine nucleotide translocator 1 (ANT‐1) mitochondrial complexation and cytochrome C (cyto‐C) release. The mPTP inhibitor sanglifehrin A (SfA) dramatically inhibited Dex‐induced...
Source: Journal of Cellular Physiology - February 25, 2014 Category: Cytology Authors: Yun‐fang Zhen, Guo‐dong Wang, Lun‐qing Zhu, Shi‐ping Tan, Fu‐yong Zhang, Xiao‐zhong Zhou, Xiao‐dong Wang Tags: Original Research Article Source Type: research