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Transplantation of IL-1 β siRNA-modified bone marrow mesenchymal stem cells ameliorates type II collagen-induced rheumatoid arthritis in rats
Exp Ther Med. 2022 Feb;23(2):139. doi: 10.3892/etm.2021.11062. Epub 2021 Dec 14.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease that causes erosion of articular cartilage and bone and has adverse effects on both patients and livestock animals. The aim of the present study was to investigate the role of interleukin-1β (IL-1β) in the pathogenesis of RA, and to further determine whether injection of IL-1β small interfering RNA (siRNA) or transplantation of IL-1β siRNA + bone marrow mesenchymal stem cells (BMSCs) can ameliorate RA in rats. A collagen-induced arthritis (CIA) rat model was established by in...
Source: Experimental and Therapeutic Medicine - January 24, 2022 Category: General Medicine Authors: Shifeng Pan Xuan Dong Yan Wang Tiansheng Zhou Yuting Liu An Zhou Hua Xing Source Type: research

Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA.
CONCLUSIONS: By inhibiting DKK-1, we were able to inhibit the proliferation, invasion and pro-inflammatory cytokine secretion of FLSs derived from RA, which was mediated by the ERK or the IRAK-1 signaling pathway. These data indicate the application of DKK-1 silencing could be a potential therapeutic approach to RA. PMID: 32068606 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - February 13, 2020 Category: General Medicine Authors: Liu YY, Wang SY, Li YN, Bian WJ, Zhang LQ, Li YH, Long L, Liu X, Zhang XW, Li ZG Tags: Chin Med J (Engl) Source Type: research

Role and mechanism of miR-144-5p in LPS-induced macrophages.
In conclusion, the data from the present study suggested that miR-144-5p overexpression reduced THP-1 macrophage cell viability and inhibited the expression of TNF-α, IL-6 and IL-8 in cells, possibly by inhibiting the expression of TLR2 and suppressing the activation of NK-κB signaling. Therefore, miR-144-5p may serve as a novel therapeutic target for the treatment of RA. PMID: 31853295 [PubMed]
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Roles of microRNA-539 and osteopontin in rheumatoid arthritis.
Authors: Liu Y, Qian K, Li C, Ma Y, Chen X Abstract The present study aimed to investigate the role and mechanism of microRNA-539 (miR-539) in rheumatoid arthritis (RA). A total of 68 RA patients and 46 osteoarthritis patients were enrolled into the current study. Peripheral blood and joint fluid were collected prior to treatment. Reverse transcription-quantitative polymerase chain reaction was performed to detect osteopontin (OPN) mRNA and miR-539 expression levels, while ELISA and western blot analysis were applied to detect OPN protein expression. In addition, bioinformatics analysis predicted that miR-539 direc...
Source: Experimental and Therapeutic Medicine - February 24, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Conclusions: We demonstrated that C/EBPβ, especially C/EBPβ-LIP in cooperation with ATF4, is involved in osteoclast formation by regulating RANKL expression in RA-FLS. These findings suggest that C/EBPβ plays a crucial role in bone destruction in RA joints.
Source: BioMed Central - February 17, 2015 Category: Journals (General) Authors: Hidetoshi TsushimaKen OkazakiKohei IshiharaTakahiro UshijimaYukihide Iwamoto Source Type: research