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Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy
In conclusion, the results suggested that GB may improve DN via protecting the kidney from ferroptosis and oxidative stress damage by inhibiting the ubiquitination of GPX4. These findings suggested that GB, a natural medicine, may be an effective therapeutic option for DN.PMID:36411664 | DOI:10.1016/j.biopha.2022.113953
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2022 Category: Drugs & Pharmacology Authors: Jing Chen Zhijie Ou Tiantian Gao Yuwei Yang Anmei Shu Huiqin Xu Yuping Chen Zhiyang Lv Source Type: research

< em > Ginkgo biloba < /em > leaf extract prevents diabetic nephropathy through the suppression of tissue transglutaminase
Exp Ther Med. 2021 Apr;21(4):333. doi: 10.3892/etm.2021.9764. Epub 2021 Feb 8.ABSTRACTThe present study aimed to investigate the preventive effects of Ginkgo biloba leaf extract (GBE) against extracellular matrix (ECM) accumulation in a streptozotocin (STZ)-induced rat model of diabetic nephropathy (DN), and to determine its underlying molecular mechanism. In vivo, a rat model of DN was established by intraperitoneal injection of STZ, and the rats were subsequently administered GBE. The results demonstrated that GBE significantly decreased blood glucose, the urine protein excretion rate and ECM accumulation in DN rats. In ...
Source: Experimental and Therapeutic Medicine - March 18, 2021 Category: General Medicine Authors: Xiaoyan Yu Qing Su Jianan Geng Hui Liu Yumeng Liu Jinming Liu Yan Shi Yinggang Zou Source Type: research

Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway.
Abstract High-glucose-induced low-grade inflammation has been regarded as a key event in the onset and progression of endothelial dysfunction in diabetic vascular complications. Ginkgolide A (GA), a major compound from Ginkgo biloba extract, is widely used for the treatment of cardiovascular diseases and diabetic vascular complications. Here, its effect on high-glucose-stimulated vascular inflammation in human umbilical vein endothelial cells (HUVECs) was investigated. In the present study, the optimal stimulation conditions for HUVECs were screened for inducing endothelial inflammation, namely, high glucose at th...
Source: International Immunopharmacology - February 11, 2015 Category: Allergy & Immunology Authors: Zhao Q, Gao C, Cui Z Tags: Int Immunopharmacol Source Type: research

Ginkgo biloba Extract Reduces High-Glucose-Induced Endothelial Reactive Oxygen Species Generation and Cell Adhesion Molecule Expression by Enhancing HO-1 Expression via Akt/eNOS and P38 MAP Kinase Pathways.
CONCLUSION: GBE could reduce high glucose-induced endothelial adhesion via enhancing HO-1 expression through the Akt/eNOS and P38/MAPK pathways. Our findings suggest a potential strategy targeting on HO-1 induction by GBE for endothelial protection in the presence of high glucose such as that in diabetes mellitus. PMID: 23357604 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - January 25, 2013 Category: Drugs & Pharmacology Authors: Tsai HY, Huang PH, Lin FY, Chen JS, Lin SJ, Chen JW Tags: Eur J Pharm Sci Source Type: research

Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB
Abstract: Chronic hyperlipidemia causes β-cell apoptosis and dysfunction, thereby contributing to the pathogenesis of type 2 diabetes (T2D). Thus, searching for agents to promote pancreatic β-cell survival and improve its function could be a promising strategy to prevent and treat T2D. We investigated the effects of kaempferol, a small molecule isolated from ginkgo biloba, on apoptosis and function of β-cells and further determined the mechanism underlying its actions. Kaempferol treatment promoted viability, inhibited apoptosis and reduced caspase-3 activity in INS-1E cells and human islets chronically exposed to palmi...
Source: The Journal of Nutritional Biochemistry - July 23, 2012 Category: Biochemistry Authors: Yanling Zhang, Wei Zhen, Pierre Maechler, Dongmin Liu Tags: Research Articles Source Type: research